Detail Information

Basic Information:


  VIRBase ID:  

HHID00016421

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:           TMEM59:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4521 TMEM59
miRBase
Accession/Entrez ID		 MIMAT0019058 9528
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C1orf8//DCF1//HSPC001//PRO195//UNQ169

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4521
rs1011991709 chr17:8186962    G/A
rs1011991709 chr17:8186962    G/C
rs1041768648 chr17:8186965    C/T
rs1056190393 chr17:8186959    C/A
rs1231036635 chr17:8186958    T/A
rs1231036635 chr17:8186958    T/G
rs1316923680 chr17:8186964    G/A
rs1316923680 chr17:8186964    G/C
rs1316923680 chr17:8186964    G/T
rs1365122718 chr17:8186957    G/C
rs559116584 chr17:8186963    T/C
rs559116584 chr17:8186963    T/G
rs561824123 chr17:8186969    G/A
rs768576971 chr17:8186966    T/A
rs768576971 chr17:8186966    T/C
rs776348878 chr17:8186967    C/A
rs893173803 chr17:8186960    C/G
rs893173803 chr17:8186960    C/T
rs999343007 chr17:8186968    A/G
rs1310598293 chr17:8186951    A/G
rs928871091 chr17:8186953    G/A
rs928871091 chr17:8186953    G/C
rs937623219 chr17:8186954    G/A
rs953552065 chr17:8186949    C/A
rs953552065 chr17:8186949    C/G
rs953552065 chr17:8186949    C/T
rs962385560 chr17:8186955    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMEM59
chr1:54501524(-) A-I      intronic
chr1:54498722(-) A-I      intronic
chr1:54499126(-) A-I      intronic
chr1:54500390(-) A-I      intronic
chr1:54499696(-) A-I      intronic
chr1:54499679(-) A-I      intronic
chr1:54499599(-) A-I      intronic
chr1:54499574(-) A-I      intronic
chr1:54499267(-) A-I      intronic
chr1:54499157(-) A-I      intronic
chr1:54499094(-) A-I      intronic
chr1:54499039(-) A-I      intronic
chr1:54499028(-) A-I      intronic
chr1:54498847(-) A-I      intronic
chr1:54498628(-) A-I      intronic
chr1:54501560(-) A-I      intronic
chr1:54501952(-) A-I      intronic
chr1:54501897(-) A-I      intronic
chr1:54501791(-) A-I      intronic
chr1:54501774(-) A-I      intronic
chr1:54501739(-) A-I      intronic
chr1:54498774(-) A-I      intronic
chr1:54501698(-) A-I      intronic
chr1:54501559(-) A-I      intronic
chr1:54501554(-) A-I      intronic
chr1:54501482(-) A-I      intronic
chr1:54501418(-) A-I      intronic
chr1:54501343(-) A-I      intronic
chr1:54501317(-) A-I      intronic
chr1:54499730(-) A-I      intronic
chr1:54499708(-) A-I      intronic
chr1:54499682(-) A-I      intronic
chr1:54501533(-) A-I      intronic
chr1:54501878(-) A-I      intronic
chr1:54501414(-) A-I      intronic
chr1:54501946(-) A-I      intronic
chr1:54501514(-) A-I      intronic
chr1:54501513(-) A-I      intronic
chr1:54498661(-) A-I      intronic
chr1:54498725(-) A-I      intronic
chr1:54516795(-) A-I      intronic
chr1:54498884(-) A-I      intronic
chr1:54501319(-) A-I      intronic
chr1:54498629(-) A-I      intronic
chr1:54498739(-) A-I      intronic
chr1:54499773(-) A-I      intronic
chr1:54501450(-) A-I      intronic
chr1:54498885(-) A-I      intronic
chr1:54516800(-) A-I      intronic
chr1:54498716(-) A-I      intronic
chr1:54516068(-) A-I      intronic
chr1:54499192(-) A-I      intronic
chr1:54499175(-) A-I      intronic
chr1:54510310(-) A-I      5'UTR
chr1:54499193(-) A-I      intronic
chr1:54515389(-) A-I      intronic
chr1:54498741(-) A-I      intronic
chr1:54501500(-) A-I      intronic
chr1:54501871(-) A-I      intronic
chr1:54501542(-) A-I      intronic
chr1:54516353(-) A-I      intronic
chr1:54515448(-) A-I      intronic
chr1:54498842(-) A-I      intronic
chr1:54499242(-) A-I      intronic
chr1:54516682(-) A-I      intronic
chr1:54501891(-) A-I      intronic
chr1:54515997(-) A-I      intronic
chr1:54499086(-) A-I      intronic
chr1:54498830(-) A-I      intronic
chr1:54516069(-) A-I      intronic
chr1:54516801(-) A-I      intronic
chr1:54501456(-) A-I      intronic
chr1:54498866(-) A-I      intronic
chr1:54501488(-) A-I      intronic
chr1:54498765(-) A-I      intronic
chr1:54515895(-) A-I      intronic
chr1:54499029(-) A-I      intronic
chr1:54498667(-) A-I      intronic
chr1:54501924(-) A-I      intronic
chr1:54515449(-) A-I      intronic
chr1:54516508(-) A-I      intronic
chr1:54499729(-) A-I      intronic
chr1:54499011(-) A-I      intronic
chr1:54501772(-) A-I      intronic
chr1:54499761(-) A-I      intronic
chr1:54501510(-) A-I      intronic
chr1:54515480(-) A-I      intronic
chr1:54498775(-) A-I      intronic
chr1:54500322(-) A-I      intronic
chr1:54499218(-) A-I      intronic
chr1:54516063(-) A-I      intronic
chr1:54498631(-) A-I      intronic
chr1:54501316(-) A-I      intronic
chr1:54500347(-) A-I      intronic
chr1:54516403(-) A-I      intronic
chr1:54499269(-) A-I      intronic
chr1:54499188(-) A-I      intronic
chr1:54501832(-) A-I      intronic
chr1:54501383(-) A-I      intronic
chr1:54498833(-) A-I      intronic
chr1:54499070(-) A-I      intronic
chr1:54498729(-) A-I      intronic
chr1:54501892(-) A-I      intronic
chr1:54515395(-) A-I      intronic
chr1:54498829(-) A-I      intronic
chr1:54516329(-) A-I      intronic
chr1:54499153(-) A-I      intronic
chr1:54498880(-) A-I      intronic
chr1:54501848(-) A-I      intronic
chr1:54501358(-) A-I      intronic
chr1:54500408(-) A-I      intronic
chr1:54498693(-) A-I      intronic
chr1:54501765(-) A-I      intronic
chr1:54501833(-) A-I      intronic
chr1:54516650(-) A-I      intronic
chr1:54515407(-) A-I      intronic
chr1:54498671(-) A-I      intronic
chr1:54501378(-) A-I      intronic
chr1:54499261(-) A-I      intronic
chr1:54501300(-) A-I      intronic
chr1:54499163(-) A-I      intronic
chr1:54501727(-) A-I      intronic
chr1:54505963(-) A-I      intronic
chr1:54516238(-) A-I      intronic
chr1:54501788(-) A-I      intronic
chr1:54498900(-) A-I      intronic
chr1:54515409(-) A-I      intronic
chr1:54499174(-) A-I      intronic
chr1:54498712(-) A-I      intronic
chr1:54498850(-) A-I      intronic
chr1:54499151(-) A-I      intronic
chr1:54501454(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMEM59
chr1:54498912(-) A-I intron -    15342557
chr1:54499029(-) A-I intron -    15342557
chr1:54499151(-) A-I intron -    15342557
chr1:54499163(-) A-I intron -    15342557
chr1:54499174(-) A-I intron -    15342557
chr1:54499192(-) A-I intron -    15342557
chr1:54499269(-) A-I intron -    15342557
chr1:54510310(-) A-I intron -    21960545
chr1:54498661(-) A-G intron -    22484847
chr1:54498712(-) A-G intron -    22484847
chr1:54498885(-) A-G intron -    22484847
chr1:54499175(-) A-G intron -    22484847
chr1:54499192(-) A-G intron -    22484847
chr1:54499193(-) A-G intron -    22484847
chr1:54501378(-) A-G intron -    22484847
chr1:54501383(-) A-G intron -    22484847
chr1:54501513(-) A-G intron -    22484847
chr1:54501765(-) A-G intron -    22484847
chr1:54501772(-) A-G intron -    22484847
chr1:54501878(-) A-G intron -    22484847
chr1:54501891(-) A-G intron -    22484847
chr1:54513526(-) A-G intron -    22484847
chr1:54513605(-) A-G intron -    22484847
chr1:54515997(-) A-G intron -    22484847
chr1:54516801(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMEM59
chr1:54494068-54494069(-) m6A 3'UTR       27773535
chr1:54494155-54494156(-) m6A 3'UTR       27773535
chr1:54494168-54494169(-) m6A 3'UTR       27773535
chr1:54509089-54509090(-) m6A CDS       26404942
chr1:54509121-54509122(-) m6A CDS       -
chr1:54518767-54518768(-) m6A CDS//intron       25456834//24981863//27371828//27773536//22575960
chr1:54518827-54518828(-) m6A CDS//intron       25456834//24981863//27371828//27773536
chr1:54518865-54518866(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//27773536
chr1:54518899-54518900(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//27773536
chr1:54518913-54518914(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//27773536
chr1:54519045-54519046(-) m1A 5'UTR       26863196
chr1:54519118-54519119(-) m1A 5'UTR       26863196
chr1:54519151-54519152(-) m6A 5'UTR       25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4521
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
TMEM59
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4521
Interactor2: TMEM59

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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