Detail Information

Basic Information:


  VIRBase ID:  

HHID00016398

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:           CD164:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4521 CD164
miRBase
Accession/Entrez ID		 MIMAT0019058 8763
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DFNA66//endolyn//MGC-24//MGC-24v//MUC-24

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4521
rs1011991709 chr17:8186962    G/A
rs1011991709 chr17:8186962    G/C
rs1041768648 chr17:8186965    C/T
rs1056190393 chr17:8186959    C/A
rs1231036635 chr17:8186958    T/A
rs1231036635 chr17:8186958    T/G
rs1316923680 chr17:8186964    G/A
rs1316923680 chr17:8186964    G/C
rs1316923680 chr17:8186964    G/T
rs1365122718 chr17:8186957    G/C
rs559116584 chr17:8186963    T/C
rs559116584 chr17:8186963    T/G
rs561824123 chr17:8186969    G/A
rs768576971 chr17:8186966    T/A
rs768576971 chr17:8186966    T/C
rs776348878 chr17:8186967    C/A
rs893173803 chr17:8186960    C/G
rs893173803 chr17:8186960    C/T
rs999343007 chr17:8186968    A/G
rs1310598293 chr17:8186951    A/G
rs928871091 chr17:8186953    G/A
rs928871091 chr17:8186953    G/C
rs937623219 chr17:8186954    G/A
rs953552065 chr17:8186949    C/A
rs953552065 chr17:8186949    C/G
rs953552065 chr17:8186949    C/T
rs962385560 chr17:8186955    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CD164
chr6:109696628(-) A-I      intronic
chr6:109692745(-) A-I      intronic
chr6:109692592(-) A-I      intronic
chr6:109692591(-) A-I      intronic
chr6:109692654(-) A-I      intronic
chr6:109696615(-) A-I      intronic
chr6:109692551(-) A-I      intronic
chr6:109696698(-) A-I      intronic
chr6:109692618(-) A-I      intronic
chr6:109696561(-) A-I      intronic
chr6:109692737(-) A-I      intronic
chr6:109696563(-) A-I      intronic
chr6:109692719(-) A-I      intronic
chr6:109696657(-) A-I      intronic
chr6:109692646(-) A-I      intronic
chr6:109692550(-) A-I      intronic
chr6:109692695(-) A-I      intronic
chr6:109696640(-) A-I      intronic
chr6:109692565(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CD164
chr6:109696434(-) A-I intron -    15545495
chr6:109696510(-) A-I intron -    15545495
chr6:109693760(-) A-I intron -    22327324
chr6:109696698(-) A-G intron -    22484847
chr6:109696830(-) T-C intron -    22484847
chr6:109696834(-) C-T intron -    22484847
chr6:109693760(-) A-G intron -    22484847
chr6:109696510(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CD164
chr6:109688011-109688012(-) m6A 3'UTR//exon       26404942
chr6:109688116-109688117(-) m6A 3'UTR//exon       26404942
chr6:109689057-109689058(-) m6A 3'UTR//exon       26404942
chr6:109689288-109689289(-) m6A 3'UTR//exon       26404942
chr6:109689390-109689391(-) m6A 3'UTR//exon       26404942//22575960
chr6:109689405-109689406(-) m6A 3'UTR//exon       26404942//22575960
chr6:109689506-109689507(-) m6A 3'UTR//CDS//exon       26404942
chr6:109689730-109689731(-) m6A 3'UTR//exon//intron       26404942
chr6:109690029-109690030(-) m6A 3'UTR//exon//intron       24284625//24981863//28052920//26404942//27773535//22575960//22608085
chr6:109690048-109690049(-) m6A 3'UTR//exon//intron       -
chr6:109690052-109690053(-) m6A 3'UTR//exon//intron       24284625//24981863//28052920//26404942//27773535//22575960//22608085
chr6:109691628-109691629(-) m6A CDS//exon//intron       24284625
chr6:109691665-109691666(-) m6A CDS//exon//intron       24284625
chr6:109691689-109691690(-) m6A exon//intron       24284625
chr6:109692895-109692896(-) m6A exon//intron       27773535
chr6:109692918-109692919(-) m6A exon//intron       27773535
chr6:109692934-109692935(-) m6A exon//intron       27773535
chr6:109692948-109692949(-) m6A exon//intron       27773535
chr6:109693003-109693004(-) m6A exon//intron       27773535
chr6:109696130-109696131(-) Am intron       -
chr6:109699113-109699114(-) m6A CDS//exon       27773535
chr6:109699122-109699123(-) m6A CDS//exon       27773535
chr6:109703504-109703505(-) m6A CDS//exon       24284625//24981863//27371828//27773536//22575960
chr6:109703510-109703511(-) m6A CDS//exon       24284625//24981863//27371828//27773536//22575960
chr6:109703585-109703586(-) m6A 5'UTR//exon       24284625//24981863//27371828//27773536//22575960
chr6:109703715-109703716(-) m6A 5'UTR       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4521
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
CD164
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4521
Interactor2: CD164

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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