Detail Information

Basic Information:


  VIRBase ID:  

HHID00016390

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:           CGGBP1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4521 CGGBP1
miRBase
Accession/Entrez ID		 MIMAT0019058 8545
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CGGBP//p20-CGGBP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4521
rs1011991709 chr17:8186962    G/A
rs1011991709 chr17:8186962    G/C
rs1041768648 chr17:8186965    C/T
rs1056190393 chr17:8186959    C/A
rs1231036635 chr17:8186958    T/A
rs1231036635 chr17:8186958    T/G
rs1316923680 chr17:8186964    G/A
rs1316923680 chr17:8186964    G/C
rs1316923680 chr17:8186964    G/T
rs1365122718 chr17:8186957    G/C
rs559116584 chr17:8186963    T/C
rs559116584 chr17:8186963    T/G
rs561824123 chr17:8186969    G/A
rs768576971 chr17:8186966    T/A
rs768576971 chr17:8186966    T/C
rs776348878 chr17:8186967    C/A
rs893173803 chr17:8186960    C/G
rs893173803 chr17:8186960    C/T
rs999343007 chr17:8186968    A/G
rs1310598293 chr17:8186951    A/G
rs928871091 chr17:8186953    G/A
rs928871091 chr17:8186953    G/C
rs937623219 chr17:8186954    G/A
rs953552065 chr17:8186949    C/A
rs953552065 chr17:8186949    C/G
rs953552065 chr17:8186949    C/T
rs962385560 chr17:8186955    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CGGBP1
chr3:88165454(-) A-I      intronic
chr3:88138397(-) A-I      intronic
chr3:88138385(-) A-I      intronic
chr3:88138457(-) A-I      intronic
chr3:88138468(-) A-I      intronic
chr3:88138474(-) A-I      intronic
chr3:88138529(-) A-I      intronic
chr3:88138533(-) A-I      intronic
chr3:88138602(-) A-I      intronic
chr3:88138610(-) A-I      intronic
chr3:88155523(-) A-I      intronic
chr3:88155603(-) A-I      intronic
chr3:88155616(-) A-I      intronic
chr3:88165508(-) A-I      intronic
chr3:88165542(-) A-I      intronic
chr3:88138196(-) A-I      intronic
chr3:88138111(-) A-I      intronic
chr3:88138165(-) A-I      intronic
chr3:88171997(-) A-I      intronic
chr3:88137969(-) A-I      intronic
chr3:88172077(-) A-I      intronic
chr3:88172121(-) A-I      intronic
chr3:88137970(-) A-I      intronic
chr3:88138209(-) A-I      intronic
chr3:88154207(-) A-I      intronic
chr3:88138087(-) A-I      intronic
chr3:88138079(-) A-I      intronic
chr3:88137965(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CGGBP1
chr3:88152257(-) A-I intron -    22327324
chr3:88197908(-) T-C intron -    22484847
chr3:88197919(-) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CGGBP1
chr3:88104100-88104101(-) m6A 3'UTR       24981863
chr3:88104149-88104150(-) m6A 3'UTR       24981863//22608085
chr3:88104253-88104254(-) m6A 3'UTR       24981863
chr3:88104695-88104696(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr3:88104809-88104810(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr3:88104834-88104835(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr3:88104930-88104931(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr3:88105006-88105007(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr3:88105077-88105078(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//22608085
chr3:88105088-88105089(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//22608085
chr3:88105147-88105148(-) m6A 5'UTR       24284625//24209618//24981863//26404942//22608085
chr3:88105191-88105192(-) m6A 5'UTR//intron       24284625//22608085
chr3:88107147-88107148(-) m6A exon//intron       27773535
chr3:88107155-88107156(-) m6A exon//intron       27773535
chr3:88107163-88107164(-) m6A exon//intron       27773535
chr3:88107176-88107177(-) m6A 5'UTR//exon//intron       27773535
chr3:88107183-88107184(-) m6A 5'UTR//exon//intron       27773535
chr3:88107215-88107216(-) m6A 5'UTR//exon//intron       27773535
chr3:88107264-88107265(-) m6A 5'UTR//exon//intron       27773535
chr3:88107292-88107293(-) m6A 5'UTR//exon//intron       27773535
chr3:88107321-88107322(-) m6A 5'UTR//exon//intron       27773535
chr3:88108120-88108121(-) m6A 5'UTR//intron       24981863
chr3:88190203-88190204(-) m6A 5'UTR       -
chr3:88190210-88190211(-) m6A 5'UTR       -
chr3:88198937-88198938(-) m6A 5'UTR       24981863//22608085
chr3:88198943-88198944(-) m6A 5'UTR       24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4521
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
CGGBP1
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4521
Interactor2: CGGBP1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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