Detail Information

Basic Information:


  VIRBase ID:  

HHID00016378

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:           ZNF230:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4521 ZNF230
miRBase
Accession/Entrez ID		 MIMAT0019058 7773
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - FDZF2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4521
rs1011991709 chr17:8186962    G/A
rs1011991709 chr17:8186962    G/C
rs1041768648 chr17:8186965    C/T
rs1056190393 chr17:8186959    C/A
rs1231036635 chr17:8186958    T/A
rs1231036635 chr17:8186958    T/G
rs1316923680 chr17:8186964    G/A
rs1316923680 chr17:8186964    G/C
rs1316923680 chr17:8186964    G/T
rs1365122718 chr17:8186957    G/C
rs559116584 chr17:8186963    T/C
rs559116584 chr17:8186963    T/G
rs561824123 chr17:8186969    G/A
rs768576971 chr17:8186966    T/A
rs768576971 chr17:8186966    T/C
rs776348878 chr17:8186967    C/A
rs893173803 chr17:8186960    C/G
rs893173803 chr17:8186960    C/T
rs999343007 chr17:8186968    A/G
rs1310598293 chr17:8186951    A/G
rs928871091 chr17:8186953    G/A
rs928871091 chr17:8186953    G/C
rs937623219 chr17:8186954    G/A
rs953552065 chr17:8186949    C/A
rs953552065 chr17:8186949    C/G
rs953552065 chr17:8186949    C/T
rs962385560 chr17:8186955    A/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZNF230
chr19:44507176-44507177(+) m6A 5'UTR//exon       24981863
chr19:44513002-44513003(+) m6A CDS       -
chr19:44513044-44513045(+) m6A CDS       -
chr19:44514428-44514429(+) m6A 3'UTR//CDS       25456834//24981863//22608085
chr19:44514445-44514446(+) m6A 3'UTR//CDS       25456834//24981863//22608085
chr19:44514456-44514457(+) m6A 3'UTR//CDS       25456834//24981863//22608085
chr19:44514481-44514482(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085
chr19:44514513-44514514(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085
chr19:44514544-44514545(+) m6A 3'UTR//CDS       24209618//24981863//22608085
chr19:44514577-44514578(+) m6A 3'UTR//CDS       24209618//24981863//22608085
chr19:44514598-44514599(+) m6A 3'UTR//CDS       24209618//24981863//22608085
chr19:44514604-44514605(+) m6A 3'UTR//CDS       24209618//24981863//22608085
chr19:44514628-44514629(+) m6A 3'UTR//CDS       24209618//24981863//22608085
chr19:44514772-44514773(+) m6A 3'UTR//CDS       24209618//22608085
chr19:44514827-44514828(+) m6A 3'UTR//CDS       22608085
chr19:44514856-44514857(+) m6A 3'UTR//CDS       22608085
chr19:44514940-44514941(+) m6A 3'UTR//CDS       24284625//22608085
chr19:44514997-44514998(+) m6A 3'UTR//CDS       24284625//22608085
chr19:44515108-44515109(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr19:44515186-44515187(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr19:44515192-44515193(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr19:44515276-44515277(+) m6A 3'UTR//CDS       24284625//24981863//22608085
chr19:44515360-44515361(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085
chr19:44515426-44515427(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr19:44515444-44515445(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr19:44515500-44515501(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr19:44515512-44515513(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr19:44515527-44515528(+) m6A 3'UTR//CDS       24981863//22608085
chr19:44515545-44515546(+) m6A 3'UTR//CDS       24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4521
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
ZNF230
Cytosol HeLa-S3 cells     -
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4521
Interactor2: ZNF230

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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