Basic Information:

  VIRBase ID:  

HHID00016367

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          ZEB1:  NM_001323677     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	ZEB1
miRBase Accession/Entrez ID	MIMAT0019058	6935
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AREB6//BZP//DELTAEF1//FECD6//NIL2A//PPCD3//TCF8//ZFHEP//ZFHX1A

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position
Lncediting	ZEB1	chr10: 31676192

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZEB1	chr10:31673005(+) A-I      intronic chr10:31628501(+) A-I      intronic chr10:31673088(+) A-I      intronic chr10:31628541(+) A-I      intronic chr10:31673085(+) A-I      intronic chr10:31673050(+) A-I      intronic chr10:31670846(+) A-I      intronic chr10:31628552(+) A-I      intronic chr10:31738888(+) A-I      intronic chr10:31636330(+) A-I      intronic chr10:31672928(+) A-I      intronic chr10:31674657(+) A-I      intronic chr10:31636419(+) A-I      intronic chr10:31673071(+) A-I      intronic chr10:31651736(+) A-I      intronic chr10:31628631(+) A-I      intronic chr10:31626793(+) A-I      intronic chr10:31674556(+) A-I      intronic chr10:31672972(+) A-I      intronic chr10:31628611(+) A-I      intronic chr10:31674678(+) A-I      intronic chr10:31718736(+) A-I      intronic chr10:31628511(+) A-I      intronic chr10:31628605(+) A-I      intronic chr10:31721254(+) A-I      intronic chr10:31626848(+) A-I      intronic chr10:31628592(+) A-I      intronic chr10:31718944(+) A-I      intronic chr10:31670865(+) A-I      intronic chr10:31636399(+) A-I      intronic chr10:31670885(+) A-I      intronic chr10:31674640(+) A-I      intronic chr10:31626671(+) A-I      intronic chr10:31674549(+) A-I      intronic chr10:31721353(+) A-I      intronic chr10:31670842(+) A-I      intronic chr10:31637278(+) A-I      intronic chr10:31628507(+) A-I      intronic chr10:31721340(+) A-I      intronic chr10:31670676(+) A-I      intronic chr10:31721460(+) A-I      intronic chr10:31721371(+) A-I      intronic chr10:31673031(+) A-I      intronic chr10:31616214(+) A-I      intronic chr10:31721470(+) A-I      intronic chr10:31721263(+) A-I      intronic chr10:31628588(+) A-I      intronic chr10:31721339(+) A-I      intronic chr10:31674619(+) A-I      intronic chr10:31770485(+) A-I      intronic chr10:31655351(+) A-I      intronic chr10:31628572(+) A-I      intronic chr10:31673022(+) A-I      intronic chr10:31670836(+) A-I      intronic chr10:31670790(+) A-I      intronic chr10:31788618(+) A-I      intronic chr10:31670793(+) A-I      intronic chr10:31673044(+) A-I      intronic chr10:31670922(+) A-I      intronic chr10:31670900(+) A-I      intronic chr10:31626826(+) A-I      intronic chr10:31670784(+) A-I      intronic chr10:31718932(+) A-I      intronic chr10:31673179(+) A-I      intronic chr10:31754567(+) A-I      intronic chr10:31673030(+) A-I      intronic chr10:31628578(+) A-I      intronic chr10:31753270(+) A-I      intronic chr10:31670769(+) A-I      intronic chr10:31628521(+) A-I      intronic chr10:31620155(+) A-I      intronic chr10:31628510(+) A-I      intronic chr10:31628481(+) A-I      intronic chr10:31721438(+) A-I      intronic chr10:31753202(+) A-I      intronic chr10:31721289(+) A-I      intronic chr10:31628539(+) A-I      intronic chr10:31657224(+) A-I      intronic chr10:31626713(+) A-I      intronic chr10:31626743(+) A-I      intronic chr10:31721424(+) A-I      intronic chr10:31637231(+) A-I      intronic chr10:31672961(+) A-I      intronic chr10:31628421(+) A-I      intronic chr10:31670782(+) A-I      intronic chr10:31626714(+) A-I      intronic chr10:31753203(+) A-I      intronic chr10:31670744(+) A-I      intronic chr10:31670890(+) A-I      intronic chr10:31670762(+) A-I      intronic chr10:31626886(+) A-I      intronic chr10:31670684(+) A-I      intronic chr10:31626740(+) A-I      intronic chr10:31670685(+) A-I      intronic chr10:31626796(+) A-I      intronic chr10:31637238(+) A-I      intronic chr10:31628579(+) A-I      intronic chr10:31670739(+) A-I      intronic chr10:31626731(+) A-I      intronic chr10:31626778(+) A-I      intronic chr10:31721473(+) A-I      intronic chr10:31628482(+) A-I      intronic chr10:31721407(+) A-I      intronic chr10:31670872(+) A-I      intronic chr10:31673114(+) A-I      intronic chr10:31670754(+) A-I      intronic chr10:31616301(+) A-I      intronic chr10:31673143(+) A-I      intronic chr10:31636362(+) A-I      intronic chr10:31670829(+) A-I      intronic chr10:31718790(+) A-I      intronic chr10:31628443(+) A-I      intronic chr10:31620222(+) A-I      intronic chr10:31718870(+) A-I      intronic chr10:31626802(+) A-I      intronic chr10:31636349(+) A-I      intronic chr10:31674667(+) A-I      intronic chr10:31626810(+) A-I      intronic chr10:31673034(+) A-I      intronic chr10:31626822(+) A-I      intronic chr10:31721256(+) A-I      intronic chr10:31718737(+) A-I      intronic chr10:31721271(+) A-I      intronic chr10:31718773(+) A-I      intronic chr10:31670881(+) A-I      intronic chr10:31718772(+) A-I      intronic chr10:31628538(+) A-I      intronic chr10:31626679(+) A-I      intronic chr10:31670819(+) A-I      intronic chr10:31673141(+) A-I      intronic chr10:31628645(+) A-I      intronic chr10:31718867(+) A-I      intronic chr10:31670725(+) A-I      intronic chr10:31670841(+) A-I      intronic chr10:31620096(+) A-I      intronic chr10:31636413(+) A-I      intronic chr10:31673173(+) A-I      intronic chr10:31754612(+) A-I      intronic chr10:31754591(+) A-I      intronic chr10:31672681(+) A-I      intronic chr10:31672152(+) A-I      intronic chr10:31754676(+) A-I      intronic chr10:31672146(+) A-I      intronic chr10:31680084(+) A-I      intronic chr10:31670761(+) A-I      intronic chr10:31801985(+) A-I      intronic chr10:31672168(+) A-I      intronic chr10:31626753(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZEB1	chr10:31626713(+) A-G intron -    22484847 chr10:31628645(+) A-G intron -    22484847 chr10:31637231(+) A-G intron -    22484847 chr10:31672961(+) A-G intron -    22484847 chr10:31718772(+) A-G intron -    22484847 chr10:31718773(+) A-G intron -    22484847 chr10:31718790(+) A-G intron -    22484847 chr10:31754567(+) A-G intron -    22484847 chr10:31754713(+) A-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZEB1	chr10:31607458-31607459(+) m6A exon       24284625//24209618//25456834//24981863//27371828//27773536 chr10:31607914-31607915(+) m6A exon       24284625//24209618//25456834//24981863//27371828//22608085 chr10:31607966-31607967(+) m6A exon       24284625//24209618//25456834//24981863 chr10:31608146-31608147(+) m6A 5'UTR//exon//intron       24981863 chr10:31608203-31608204(+) m6A CDS//exon//intron       24981863 chr10:31609058-31609059(+) m6A 5'UTR//exon//intron       24981863 chr10:31609122-31609123(+) m6A 5'UTR//exon//intron       - chr10:31749991-31749992(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24209618//24981863 chr10:31750016-31750017(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24209618//24981863 chr10:31750037-31750038(+) m1A 3'UTR//5'UTR//CDS//exon//intron       26863196 chr10:31750097-31750098(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//24981863 chr10:31750102-31750103(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//24981863 chr10:31750148-31750149(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//24981863 chr10:31750164-31750165(+) Cm 3'UTR//5'UTR//CDS//exon//intron       - chr10:31791317-31791318(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625 chr10:31791356-31791357(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625 chr10:31809172-31809173(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:31809177-31809178(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:31809184-31809185(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:31809267-31809268(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr10:31809279-31809280(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr10:31809304-31809305(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr10:31809309-31809310(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr10:31809330-31809331(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr10:31809582-31809583(+) m6A 3'UTR//CDS//exon       24981863 chr10:31809589-31809590(+) m6A 3'UTR//CDS//exon       24981863 chr10:31809670-31809671(+) m6A 3'UTR//CDS//exon       22608085 chr10:31809764-31809765(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr10:31809818-31809819(+) m6A 3'UTR//CDS//exon       24209618//24981863//22608085 chr10:31810034-31810035(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr10:31810118-31810119(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:31810167-31810168(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:31810191-31810192(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:31810206-31810207(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:31810235-31810236(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:31810269-31810270(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22608085 chr10:31810277-31810278(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22608085 chr10:31810388-31810389(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr10:31810461-31810462(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr10:31810535-31810536(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr10:31810560-31810561(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr10:31810568-31810569(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr10:31810601-31810602(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr10:31810616-31810617(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr10:31810623-31810624(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr10:31810724-31810725(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr10:31810827-31810828(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr10:31812868-31812869(+) m6A 3'UTR//CDS//exon       22608085 chr10:31812953-31812954(+) m6A 3'UTR//CDS//exon       27773535 chr10:31813021-31813022(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535 chr10:31813033-31813034(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535 chr10:31815606-31815607(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535 chr10:31815642-31815643(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr10:31815648-31815649(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr10:31815663-31815664(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr10:31815803-31815804(+) Cm 3'UTR//CDS//exon       - chr10:31815920-31815921(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085 chr10:31815990-31815991(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085 chr10:31816028-31816029(+) m1A 3'UTR//CDS//exon       26863196 chr10:31816037-31816038(+) m1A 3'UTR//CDS//exon       26863196 chr10:31816073-31816074(+) m1A 3'UTR//CDS//exon       26863196 chr10:31816081-31816082(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr10:31816134-31816135(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr10:31816177-31816178(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr10:31816266-31816267(+) m6A 3'UTR//exon       22608085 chr10:31816317-31816318(+) m6A 3'UTR//exon       22608085 chr10:31816340-31816341(+) m6A 3'UTR//exon       24981863//22608085 chr10:31816403-31816404(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr10:31816410-31816411(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr10:31816446-31816447(+) m6A 3'UTR//exon       24981863//22608085 chr10:31816476-31816477(+) m6A 3'UTR//exon       24981863//22608085 chr10:31817180-31817181(+) m6A 3'UTR//exon       24981863 chr10:31817187-31817188(+) m6A 3'UTR//exon       24981863 chr10:31817208-31817209(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	ZEB1	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: ZEB1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).