Basic Information:

  VIRBase ID:  

HHID00016322

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          PIK3CG:  NM_002649     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	PIK3CG
miRBase Accession/Entrez ID	MIMAT0019058	5294
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	p110gamma//p120-PI3K//PI3CG//PI3K//PI3Kgamma//PIK3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PIK3CG	chr7:106521177(+) A-I      intronic chr7:106521175(+) A-I      intronic chr7:106522298(+) A-I      intronic chr7:106522108(+) A-I      intronic chr7:106522037(+) A-I      intronic chr7:106521227(+) A-I      intronic chr7:106517396(+) A-I      intronic chr7:106517442(+) A-I      intronic chr7:106517457(+) A-I      intronic chr7:106521250(+) A-I      intronic chr7:106522106(+) A-I      intronic chr7:106521257(+) A-I      intronic chr7:106522215(+) A-I      intronic chr7:106521160(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PIK3CG	chr7:106516354(+) G-T intron -    22484847 chr7:106521250(+) A-G intron -    22484847 chr7:106521257(+) A-G intron -    22484847 chr7:106521326(+) A-G intron -    22484847 chr7:106522106(+) A-G intron -    22484847 chr7:106522215(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PIK3CG	chr7:106508246-106508247(+) m6A CDS//intron       - chr7:106508262-106508263(+) m6A CDS//intron       - chr7:106508281-106508282(+) m6A CDS//intron       - chr7:106508357-106508358(+) m6A CDS//intron       - chr7:106508364-106508365(+) m6A CDS//intron       - chr7:106508806-106508807(+) m6A CDS//intron       - chr7:106508871-106508872(+) m6A CDS//intron       25456834 chr7:106508928-106508929(+) m6A CDS//intron       25456834 chr7:106508940-106508941(+) m6A CDS//intron       25456834 chr7:106509039-106509040(+) m6A CDS//intron       - chr7:106509072-106509073(+) m6A CDS//intron       - chr7:106509132-106509133(+) m6A CDS//intron       - chr7:106509162-106509163(+) m6A CDS//intron       - chr7:106509483-106509484(+) m6A CDS//intron       - chr7:106509508-106509509(+) m6A CDS//intron       - chr7:106509531-106509532(+) m6A CDS//intron       - chr7:106509540-106509541(+) m6A CDS//intron       - chr7:106509567-106509568(+) m6A CDS//intron       - chr7:106509627-106509628(+) m6A CDS//intron       - chr7:106509717-106509718(+) m6A CDS//intron       - chr7:106509802-106509803(+) m6A CDS//intron       - chr7:106509824-106509825(+) m6A CDS//intron       - chr7:106509900-106509901(+) m6A CDS//intron       - chr7:106509946-106509947(+) m6A CDS//intron       - chr7:106545807-106545808(+) m6A CDS       - chr7:106545819-106545820(+) m6A CDS       - chr7:106545853-106545854(+) m6A 3'UTR       - chr7:106545897-106545898(+) m6A 3'UTR       - chr7:106545919-106545920(+) m6A 3'UTR       - chr7:106545967-106545968(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	PIK3CG	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: PIK3CG

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).