Basic Information:

  VIRBase ID:  

HHID00016314

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          PCYT1A:  NM_005017     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	PCYT1A
miRBase Accession/Entrez ID	MIMAT0019058	5130
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CCTA//CCTalpha//CT//CTA//CTPCT//PCYT1//SMDCRD

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PCYT1A	chr3:195983580(-) A-I      intronic chr3:195983579(-) A-I      intronic chr3:195983496(-) A-I      intronic chr3:195960384(-) A-I      intronic chr3:195960377(-) A-I      intronic chr3:195957556(-) A-I      intronic chr3:195957493(-) A-I      intronic chr3:195983473(-) A-I      intronic chr3:195983359(-) A-I      intronic chr3:195983327(-) A-I      intronic chr3:195983279(-) A-I      intronic chr3:195983249(-) A-I      intronic chr3:195983198(-) A-I      intronic chr3:195981497(-) A-I      intronic chr3:195981489(-) A-I      intronic chr3:195981362(-) A-I      intronic chr3:195980206(-) A-I      intronic chr3:195980175(-) A-I      intronic chr3:195980123(-) A-I      intronic chr3:195980096(-) A-I      intronic chr3:195980042(-) A-I      intronic chr3:195980036(-) A-I      intronic chr3:195980004(-) A-I      intronic chr3:195979682(-) A-I      intronic chr3:195979678(-) A-I      intronic chr3:195979294(-) A-I      intronic chr3:195979292(-) A-I      intronic chr3:195979173(-) A-I      intronic chr3:195975865(-) A-I      intronic chr3:195975325(-) A-I      intronic chr3:195975295(-) A-I      intronic chr3:195973371(-) A-I      intronic chr3:195973357(-) A-I      intronic chr3:195972784(-) A-I      intronic chr3:195972214(-) A-I      intronic chr3:195972105(-) A-I      intronic chr3:195972098(-) A-I      intronic chr3:195970077(-) A-I      intronic chr3:195970074(-) A-I      intronic chr3:195970051(-) A-I      intronic chr3:195970034(-) A-I      intronic chr3:195970031(-) A-I      intronic chr3:195970017(-) A-I      intronic chr3:195970000(-) A-I      intronic chr3:195968272(-) A-I      intronic chr3:195961201(-) A-I      intronic chr3:195994397(-) A-I      intronic chr3:195972188(-) A-I      intronic chr3:195970137(-) A-I      intronic chr3:195961145(-) A-I      intronic chr3:195961130(-) A-I      intronic chr3:195961116(-) A-I      intronic chr3:195961109(-) A-I      intronic chr3:195961092(-) A-I      intronic chr3:195961070(-) A-I      intronic chr3:195961044(-) A-I      intronic chr3:195961043(-) A-I      intronic chr3:195961031(-) A-I      intronic chr3:195961028(-) A-I      intronic chr3:195960977(-) A-I      intronic chr3:195960972(-) A-I      intronic chr3:195960950(-) A-I      intronic chr3:195960949(-) A-I      intronic chr3:195960485(-) A-I      intronic chr3:195960461(-) A-I      intronic chr3:195960458(-) A-I      intronic chr3:195960448(-) A-I      intronic chr3:195960436(-) A-I      intronic chr3:195960423(-) A-I      intronic chr3:195983680(-) A-I      intronic chr3:195961002(-) A-I      intronic chr3:195986608(-) A-I      intronic chr3:196010138(-) A-I      intronic chr3:196013703(-) A-I      intronic chr3:196012324(-) A-I      intronic chr3:196012118(-) A-I      intronic chr3:196012095(-) A-I      intronic chr3:196010188(-) A-I      intronic chr3:196010169(-) A-I      intronic chr3:196010161(-) A-I      intronic chr3:196010086(-) A-I      intronic chr3:196006944(-) A-I      intronic chr3:196006939(-) A-I      intronic chr3:196006817(-) A-I      intronic chr3:196006811(-) A-I      intronic chr3:196004620(-) A-I      intronic chr3:195998506(-) A-I      intronic chr3:195997006(-) A-I      intronic chr3:195993558(-) A-I      intronic chr3:195993543(-) A-I      intronic chr3:195988584(-) A-I      intronic chr3:195988578(-) A-I      intronic chr3:195988575(-) A-I      intronic chr3:195987680(-) A-I      intronic chr3:195987613(-) A-I      intronic chr3:195986891(-) A-I      intronic chr3:195986890(-) A-I      intronic chr3:195985118(-) A-I      intronic chr3:195983629(-) A-I      intronic chr3:195983614(-) A-I      intronic chr3:195983604(-) A-I      intronic chr3:195963731(-) A-I      3'UTR chr3:195963741(-) A-I      3'UTR chr3:195963751(-) A-I      3'UTR chr3:195963756(-) A-I      3'UTR chr3:195963802(-) A-I      3'UTR chr3:195963675(-) A-I      3'UTR chr3:195963754(-) A-I      3'UTR chr3:195963630(-) A-I      3'UTR chr3:195963634(-) A-I      3'UTR chr3:195963635(-) A-I      3'UTR chr3:195963643(-) A-I      3'UTR chr3:195963649(-) A-I      3'UTR chr3:195963653(-) A-I      3'UTR chr3:195963666(-) A-I      3'UTR chr3:195963676(-) A-I      3'UTR chr3:195963702(-) A-I      3'UTR chr3:195963716(-) A-I      3'UTR chr3:195963717(-) A-I      3'UTR chr3:195963720(-) A-I      3'UTR chr3:195979211(-) A-I      intronic chr3:195985638(-) A-I      intronic chr3:195979385(-) A-I      intronic chr3:195979642(-) A-I      intronic chr3:195982457(-) A-I      intronic chr3:195972739(-) A-I      intronic chr3:195960443(-) A-I      intronic chr3:195967961(-) A-I      intronic chr3:195979964(-) A-I      intronic chr3:195975443(-) A-I      intronic chr3:195993655(-) A-I      intronic chr3:195972284(-) A-I      intronic chr3:195975380(-) A-I      intronic chr3:195986659(-) A-I      intronic chr3:195984993(-) A-I      intronic chr3:195968286(-) A-I      intronic chr3:195984990(-) A-I      intronic chr3:195989830(-) A-I      intronic chr3:196008761(-) A-I      intronic chr3:195983694(-) A-I      intronic chr3:195975826(-) A-I      intronic chr3:195985525(-) A-I      intronic chr3:195986458(-) A-I      intronic chr3:195976032(-) A-I      intronic chr3:195998006(-) A-I      intronic chr3:195968135(-) A-I      intronic chr3:196004736(-) A-I      intronic chr3:196013023(-) A-I      intronic chr3:195996817(-) A-I      intronic chr3:195994506(-) A-I      intronic chr3:195985587(-) A-I      intronic chr3:195979334(-) A-I      intronic chr3:195992204(-) A-I      intronic chr3:195981445(-) A-I      intronic chr3:195986987(-) A-I      intronic chr3:195987053(-) A-I      intronic chr3:195989838(-) A-I      intronic chr3:195968256(-) A-I      intronic chr3:195987074(-) A-I      intronic chr3:195967326(-) A-I      intronic chr3:195999220(-) A-I      intronic chr3:195972177(-) A-I      intronic chr3:196013010(-) A-I      intronic chr3:195979257(-) A-I      intronic chr3:195994330(-) A-I      intronic chr3:195990251(-) A-I      intronic chr3:195975749(-) A-I      intronic chr3:196006733(-) A-I      intronic chr3:195987677(-) A-I      intronic chr3:195976260(-) A-I      intronic chr3:195990668(-) A-I      intronic chr3:195979966(-) A-I      intronic chr3:195972710(-) A-I      intronic chr3:196008667(-) A-I      intronic chr3:195990243(-) A-I      intronic chr3:195999350(-) A-I      intronic chr3:195972192(-) A-I      intronic chr3:195972783(-) A-I      intronic chr3:196005789(-) A-I      intronic chr3:195996917(-) A-I      intronic chr3:195995566(-) A-I      intronic chr3:195993734(-) A-I      intronic chr3:195983483(-) A-I      intronic chr3:195967960(-) A-I      intronic chr3:196006037(-) A-I      intronic chr3:195986594(-) A-I      intronic chr3:195999471(-) A-I      intronic chr3:195975910(-) A-I      intronic chr3:195986471(-) A-I      intronic chr3:195975534(-) A-I      intronic chr3:195983575(-) A-I      intronic chr3:195986568(-) A-I      intronic chr3:195983181(-) A-I      intronic chr3:195976236(-) A-I      intronic chr3:195968336(-) A-I      intronic chr3:195993742(-) A-I      intronic chr3:195983665(-) A-I      intronic chr3:195986630(-) A-I      intronic chr3:195981170(-) A-I      intronic chr3:196008837(-) A-I      intronic chr3:195983705(-) A-I      intronic chr3:195996882(-) A-I      intronic chr3:195993087(-) A-I      intronic chr3:195988552(-) A-I      intronic chr3:195967339(-) A-I      intronic chr3:195972257(-) A-I      intronic chr3:195999256(-) A-I      intronic chr3:195994504(-) A-I      intronic chr3:195982558(-) A-I      intronic chr3:196013026(-) A-I      intronic chr3:195987061(-) A-I      intronic chr3:195960395(-) A-I      intronic chr3:195975522(-) A-I      intronic chr3:196008805(-) A-I      intronic chr3:195973374(-) A-I      intronic chr3:195975849(-) A-I      intronic chr3:195972658(-) A-I      intronic chr3:196010164(-) A-I      intronic chr3:195986603(-) A-I      intronic chr3:195990363(-) A-I      intronic chr3:195995542(-) A-I      intronic chr3:195978919(-) A-I      intronic chr3:196006743(-) A-I      intronic chr3:195985666(-) A-I      intronic chr3:196013759(-) A-I      intronic chr3:195983543(-) A-I      intronic chr3:196006075(-) A-I      intronic chr3:195990255(-) A-I      intronic chr3:195973402(-) A-I      intronic chr3:195975381(-) A-I      intronic chr3:195993222(-) A-I      intronic chr3:195975792(-) A-I      intronic chr3:195968291(-) A-I      intronic chr3:195986009(-) A-I      intronic chr3:195979992(-) A-I      intronic chr3:195983315(-) A-I      intronic chr3:195979640(-) A-I      intronic chr3:195975695(-) A-I      intronic chr3:196008723(-) A-I      intronic chr3:195983692(-) A-I      intronic chr3:195993612(-) A-I      intronic chr3:195987672(-) A-I      intronic chr3:195968302(-) A-I      intronic chr3:195983685(-) A-I      intronic chr3:195998034(-) A-I      intronic chr3:196008841(-) A-I      intronic chr3:195979256(-) A-I      intronic chr3:195992706(-) A-I      intronic chr3:195972151(-) A-I      intronic chr3:195970009(-) A-I      intronic chr3:195960422(-) A-I      intronic chr3:195983237(-) A-I      intronic chr3:195983527(-) A-I      intronic chr3:195970087(-) A-I      intronic chr3:195986523(-) A-I      intronic chr3:195986053(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PCYT1A	chr3:195968256(-) A-I intron -    22327324 chr3:195968336(-) A-I intron -    22327324 chr3:195967338(-) A-G intron -    22484847 chr3:195967339(-) A-G intron -    22484847 chr3:195967960(-) A-G intron -    22484847 chr3:195967961(-) A-G intron -    22484847 chr3:195968230(-) G-A intron -    22484847 chr3:195968256(-) A-G intron -    22484847 chr3:195968302(-) A-G intron -    22484847 chr3:195968336(-) A-G intron -    22484847 chr3:195970009(-) A-G intron -    22484847 chr3:195970087(-) A-G intron -    22484847 chr3:195975910(-) A-G intron -    22484847 chr3:195978919(-) A-G intron -    22484847 chr3:195979211(-) A-G intron -    22484847 chr3:195979992(-) A-G intron -    22484847 chr3:195981360(-) A-G intron -    22484847 chr3:195983181(-) A-G intron -    22484847 chr3:195983237(-) A-G intron -    22484847 chr3:195983239(-) A-G intron -    22484847 chr3:195983314(-) A-G intron -    22484847 chr3:195983315(-) A-G intron -    22484847 chr3:195983527(-) A-G intron -    22484847 chr3:195983543(-) A-G intron -    22484847 chr3:195983549(-) A-G intron -    22484847 chr3:195983575(-) A-G intron -    22484847 chr3:195983692(-) A-G intron -    22484847 chr3:195984993(-) A-G intron -    22484847 chr3:195985638(-) A-G intron -    22484847 chr3:195988561(-) A-G intron -    22484847 chr3:195992204(-) A-G intron -    22484847 chr3:195993612(-) A-G intron -    22484847 chr3:195993613(-) A-G intron -    22484847 chr3:196006075(-) A-G intron -    22484847 chr3:196013026(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PCYT1A	chr3:195956926-195956927(-) m6A CDS//intron       27773535 chr3:195961403-195961404(-) m6A 3'UTR//intron       24284625//24981863//28052920//27773535//22575960//22608085 chr3:195961423-195961424(-) m6A 3'UTR//intron       24284625//24981863//28052920//27773535//22575960//22608085 chr3:195961473-195961474(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:195961487-195961488(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:195962398-195962399(-) m6A 3'UTR//intron       27773535 chr3:195963486-195963487(-) m6A 3'UTR//intron       24981863//27773535 chr3:195963491-195963492(-) m6A 3'UTR//intron       24981863//27773535 chr3:195963539-195963540(-) m6A 3'UTR//intron       24981863//27773535 chr3:195963545-195963546(-) m6A 3'UTR//intron       24981863//27773535 chr3:195963550-195963551(-) m6A 3'UTR//intron       24981863//27773535 chr3:195963564-195963565(-) m6A 3'UTR//intron       24981863//27773535 chr3:195963633-195963634(-) m6A 3'UTR//intron       24981863//27773535 chr3:195964376-195964377(-) m6A 3'UTR//intron       24284625 chr3:195964425-195964426(-) m6A 3'UTR//intron       24284625 chr3:195964440-195964441(-) m6A 3'UTR//intron       24284625 chr3:195964496-195964497(-) m6A 3'UTR//intron       24284625//24981863//27773535 chr3:195964571-195964572(-) m6A 3'UTR//intron       27773535//22608085 chr3:195964711-195964712(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr3:195964748-195964749(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr3:195964816-195964817(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr3:195964865-195964866(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr3:195964887-195964888(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr3:195964907-195964908(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr3:195964945-195964946(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085 chr3:195965220-195965221(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr3:195965357-195965358(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:195965404-195965405(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:195965410-195965411(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:195965419-195965420(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:195965426-195965427(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:195965443-195965444(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:195965460-195965461(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:195965468-195965469(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr3:195965562-195965563(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr3:195965638-195965639(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828 chr3:195965762-195965763(-) m6A CDS//exon//intron       24981863//27371828 chr3:195968867-195968868(-) m6A CDS//intron       27773535 chr3:195968915-195968916(-) m6A CDS//intron       27773535 chr3:195968937-195968938(-) m6A CDS//exon//intron       27773535 chr3:195997322-195997323(-) m1A CDS//exon       26863196//26863410 chr3:195997342-195997343(-) m6A CDS//exon       24981863//27773535//27371828 chr3:196014119-196014120(-) m6A 5'UTR//intron       25456834//24981863//27773535//27371828//22575960 chr3:196014432-196014433(-) m6A 5'UTR//exon//intron       25456834//24981863//27773535//27371828//22575960 chr3:196014450-196014451(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//27773535//27371828//22575960 chr3:196014512-196014513(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//27371828 chr3:196014615-196014616(-) m6A 5'UTR//exon//intron       24981863//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	PCYT1A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: PCYT1A

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).