Detail Information

Basic Information:


  VIRBase ID:  

HHID00016311

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:           OXCT1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4521 OXCT1
miRBase
Accession/Entrez ID		 MIMAT0019058 5019
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - OXCT//SCOT

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4521
rs1011991709 chr17:8186962    G/A
rs1011991709 chr17:8186962    G/C
rs1041768648 chr17:8186965    C/T
rs1056190393 chr17:8186959    C/A
rs1231036635 chr17:8186958    T/A
rs1231036635 chr17:8186958    T/G
rs1316923680 chr17:8186964    G/A
rs1316923680 chr17:8186964    G/C
rs1316923680 chr17:8186964    G/T
rs1365122718 chr17:8186957    G/C
rs559116584 chr17:8186963    T/C
rs559116584 chr17:8186963    T/G
rs561824123 chr17:8186969    G/A
rs768576971 chr17:8186966    T/A
rs768576971 chr17:8186966    T/C
rs776348878 chr17:8186967    C/A
rs893173803 chr17:8186960    C/G
rs893173803 chr17:8186960    C/T
rs999343007 chr17:8186968    A/G
rs1310598293 chr17:8186951    A/G
rs928871091 chr17:8186953    G/A
rs928871091 chr17:8186953    G/C
rs937623219 chr17:8186954    G/A
rs953552065 chr17:8186949    C/A
rs953552065 chr17:8186949    C/G
rs953552065 chr17:8186949    C/T
rs962385560 chr17:8186955    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR OXCT1
chr5:41733477(-) A-I      intronic
chr5:41733465(-) A-I      intronic
chr5:41739778(-) A-I      intronic
chr5:41741258(-) A-I      intronic
chr5:41770112(-) A-I      intronic
chr5:41770134(-) A-I      intronic
chr5:41770129(-) A-I      intronic
chr5:41741191(-) A-I      intronic
chr5:41741177(-) A-I      intronic
chr5:41739926(-) A-I      intronic
chr5:41739910(-) A-I      intronic
chr5:41739851(-) A-I      intronic
chr5:41739825(-) A-I      intronic
chr5:41733486(-) A-I      intronic
chr5:41733481(-) A-I      intronic
chr5:41769595(-) A-I      intronic
chr5:41773505(-) A-I      intronic
chr5:41739803(-) A-I      intronic
chr5:41741250(-) A-I      intronic
chr5:41782334(-) A-I      intronic
chr5:41769607(-) A-I      intronic
chr5:41741181(-) A-I      intronic
chr5:41828252(-) A-I      intronic
chr5:41822590(-) A-I      intronic
chr5:41828316(-) A-I      intronic
chr5:41741257(-) A-I      intronic
chr5:41741190(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED OXCT1
chr5:41741190(-) A-G intron -    22484847
chr5:41741250(-) A-G intron -    22484847
chr5:41773505(-) A-G intron -    22484847
chr5:41838966(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase OXCT1
chr5:41730295-41730296(-) m6A 3'UTR       27773535
chr5:41731684-41731685(-) m6A 3'UTR//exon       27773535//22608085
chr5:41731703-41731704(-) m6A 3'UTR//exon       27773535//22608085
chr5:41731765-41731766(-) m6A 3'UTR//exon       27773535//22608085
chr5:41731788-41731789(-) m6A 3'UTR//exon       27773535//22608085
chr5:41731860-41731861(-) m6A CDS//exon       27773535
chr5:41794176-41794177(-) m6A 5'UTR//CDS//exon//intron       -
chr5:41794225-41794226(-) m6A exon//intron       -
chr5:41805735-41805736(-) m6A CDS//intron       -
chr5:41842800-41842801(-) m6A CDS//exon       22575960
chr5:41843683-41843684(-) m6A 5'UTR//intron       27773535//22575960
chr5:41843701-41843702(-) m6A 5'UTR//intron       27773535//22575960
chr5:41850208-41850209(-) m6A CDS       22575960
chr5:41870445-41870446(-) m6A CDS       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4521
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
OXCT1
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4521
Interactor2: OXCT1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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