Detail Information

Basic Information:


  VIRBase ID:  

HHID00016234

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:           ELK3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4521 ELK3
miRBase
Accession/Entrez ID		 MIMAT0019058 2004
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ERP//NET//SAP-2//SAP2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4521
rs1011991709 chr17:8186962    G/A
rs1011991709 chr17:8186962    G/C
rs1041768648 chr17:8186965    C/T
rs1056190393 chr17:8186959    C/A
rs1231036635 chr17:8186958    T/A
rs1231036635 chr17:8186958    T/G
rs1316923680 chr17:8186964    G/A
rs1316923680 chr17:8186964    G/C
rs1316923680 chr17:8186964    G/T
rs1365122718 chr17:8186957    G/C
rs559116584 chr17:8186963    T/C
rs559116584 chr17:8186963    T/G
rs561824123 chr17:8186969    G/A
rs768576971 chr17:8186966    T/A
rs768576971 chr17:8186966    T/C
rs776348878 chr17:8186967    C/A
rs893173803 chr17:8186960    C/G
rs893173803 chr17:8186960    C/T
rs999343007 chr17:8186968    A/G
rs1310598293 chr17:8186951    A/G
rs928871091 chr17:8186953    G/A
rs928871091 chr17:8186953    G/C
rs937623219 chr17:8186954    G/A
rs953552065 chr17:8186949    C/A
rs953552065 chr17:8186949    C/G
rs953552065 chr17:8186949    C/T
rs962385560 chr17:8186955    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ELK3
chr12:96596366(+) A-I      intronic
chr12:96626229(+) A-I      intronic
chr12:96626255(+) A-I      intronic
chr12:96626270(+) A-I      intronic
chr12:96626225(+) A-I      intronic
chr12:96626227(+) A-I      intronic
chr12:96626228(+) A-I      intronic
chr12:96625400(+) A-I      intronic
chr12:96608111(+) A-I      intronic
chr12:96594405(+) A-I      intronic
chr12:96607573(+) A-I      intronic
chr12:96607571(+) A-I      intronic
chr12:96621942(+) A-I      intronic
chr12:96607629(+) A-I      intronic
chr12:96594425(+) A-I      intronic
chr12:96607954(+) A-I      intronic
chr12:96608169(+) A-I      intronic
chr12:96596422(+) A-I      intronic
chr12:96608155(+) A-I      intronic
chr12:96619799(+) A-I      intronic
chr12:96658483(+) A-I      intronic
chr12:96658448(+) A-I      intronic
chr12:96658449(+) A-I      intronic
chr12:96595322(+) A-I      intronic
chr12:96626188(+) A-I      intronic
chr12:96619894(+) A-I      intronic
chr12:96621842(+) A-I      intronic
chr12:96594496(+) A-I      intronic
chr12:96625436(+) A-I      intronic
chr12:96597682(+) A-I      intronic
chr12:96658533(+) A-I      intronic
chr12:96595244(+) A-I      intronic
chr12:96658352(+) A-I      intronic
chr12:96607621(+) A-I      intronic
chr12:96595167(+) A-I      intronic
chr12:96657946(+) A-I      intronic
chr12:96607953(+) A-I      intronic
chr12:96597701(+) A-I      intronic
chr12:96659311(+) A-I      intronic
chr12:96656079(+) A-I      intronic
chr12:96611605(+) A-I      intronic
chr12:96659343(+) A-I      intronic
chr12:96609429(+) A-I      intronic
chr12:96622117(+) A-I      intronic
chr12:96626449(+) A-I      intronic
chr12:96637501(+) A-I      intronic
chr12:96626433(+) A-I      intronic
chr12:96607633(+) A-I      intronic
chr12:96655930(+) A-I      intronic
chr12:96657965(+) A-I      intronic
chr12:96659414(+) A-I      intronic
chr12:96631466(+) A-I      intronic
chr12:96658455(+) A-I      intronic
chr12:96625410(+) A-I      intronic
chr12:96611601(+) A-I      intronic
chr12:96657819(+) A-I      intronic
chr12:96608179(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ELK3
chr12:96657847(+) T-C intron -    22484847
chr12:96657852(+) T-C intron -    22484847
chr12:96657925(+) T-C intron -    22484847
chr12:96657940(+) T-C intron -    22484847
chr12:96658014(+) T-C intron -    22484847
chr12:96658395(+) T-C intron -    22484847
chr12:96658477(+) T-C intron -    22484847
chr12:96658525(+) T-C intron -    22484847
chr12:96658549(+) T-C intron -    22484847
chr12:96594496(+) A-G intron -    22484847
chr12:96647891(+) T-C intron -    22484847
chr12:96655960(+) T-C intron -    22484847
chr12:96657840(+) T-C intron -    22484847
chr12:96657878(+) T-C intron -    22484847
chr12:96657883(+) T-C intron -    22484847
chr12:96657921(+) T-C intron -    22484847
chr12:96657930(+) T-C intron -    22484847
chr12:96658018(+) T-C intron -    22484847
chr12:96658022(+) T-C intron -    22484847
chr12:96658366(+) T-C intron -    22484847
chr12:96659229(+) T-C intron -    22484847
chr12:96659297(+) T-C intron -    22484847
chr12:96659298(+) T-C intron -    22484847
chr12:96659410(+) T-C intron -    22484847
chr12:96659451(+) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ELK3
chr12:96588230-96588231(+) m6A 5'UTR       24981863
chr12:96588390-96588391(+) m6A 5'UTR       24981863
chr12:96617400-96617401(+) m6A CDS       24981863
chr12:96617422-96617423(+) m6A CDS       24981863
chr12:96617481-96617482(+) m6A CDS       24981863
chr12:96617492-96617493(+) m6A CDS       24981863
chr12:96617497-96617498(+) m6A CDS       24981863
chr12:96617507-96617508(+) m6A CDS       24981863//26404942
chr12:96640835-96640836(+) m6A CDS//intron       25456834//24981863//22608085
chr12:96640878-96640879(+) m6A CDS//intron       24209618//24981863//22608085
chr12:96640967-96640968(+) m6A CDS//intron       24209618//25456834//24981863//26404942
chr12:96641024-96641025(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942
chr12:96641050-96641051(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942
chr12:96641077-96641078(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942
chr12:96641274-96641275(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085
chr12:96641333-96641334(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22608085
chr12:96641353-96641354(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22608085
chr12:96641388-96641389(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22608085
chr12:96649264-96649265(+) m6A exon//intron       24284625//24209618//25456834//24981863
chr12:96649314-96649315(+) m6A exon//intron       24209618
chr12:96660908-96660909(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863
chr12:96660941-96660942(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863
chr12:96660980-96660981(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942
chr12:96660997-96660998(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942
chr12:96661041-96661042(+) m6A 3'UTR//exon       24209618//24981863//26404942
chr12:96661051-96661052(+) m6A 3'UTR//exon       24209618//24981863//26404942
chr12:96661118-96661119(+) m6A 3'UTR//exon       24209618//24981863
chr12:96662788-96662789(+) m6A 3'UTR       26404942

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4521
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
ELK3
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4521
Interactor2: ELK3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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