Basic Information:

  VIRBase ID:  

HHID00016216

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4521:  MIMAT0019058          TPP1:  NM_000391     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4521	TPP1
miRBase Accession/Entrez ID	MIMAT0019058	1200
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CLN2//GIG1//LPIC//SCAR7//TPP-1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4521	rs1011991709 chr17:8186962    G/A rs1011991709 chr17:8186962    G/C rs1041768648 chr17:8186965    C/T rs1056190393 chr17:8186959    C/A rs1231036635 chr17:8186958    T/A rs1231036635 chr17:8186958    T/G rs1316923680 chr17:8186964    G/A rs1316923680 chr17:8186964    G/C rs1316923680 chr17:8186964    G/T rs1365122718 chr17:8186957    G/C rs559116584 chr17:8186963    T/C rs559116584 chr17:8186963    T/G rs561824123 chr17:8186969    G/A rs768576971 chr17:8186966    T/A rs768576971 chr17:8186966    T/C rs776348878 chr17:8186967    C/A rs893173803 chr17:8186960    C/G rs893173803 chr17:8186960    C/T rs999343007 chr17:8186968    A/G rs1310598293 chr17:8186951    A/G rs928871091 chr17:8186953    G/A rs928871091 chr17:8186953    G/C rs937623219 chr17:8186954    G/A rs953552065 chr17:8186949    C/A rs953552065 chr17:8186949    C/G rs953552065 chr17:8186949    C/T rs962385560 chr17:8186955    A/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TPP1	chr11:6634085-6634086(-) m6A 3'UTR       27773535 chr11:6634571-6634572(-) m6A 3'UTR       24284625//24981863//28052920//27773535 chr11:6634581-6634582(-) m6A 3'UTR       24284625//24981863//28052920//27773535 chr11:6634637-6634638(-) m6A 3'UTR       24284625//24981863//27773535 chr11:6634701-6634702(-) m6A 3'UTR       24981863//27773535 chr11:6634840-6634841(-) m6A 3'UTR       24981863//27773535 chr11:6634971-6634972(-) m6A 3'UTR       24981863//27773535 chr11:6635031-6635032(-) m6A 3'UTR       24981863//27773535 chr11:6635113-6635114(-) m6A 3'UTR       27773535 chr11:6635157-6635158(-) m6A 3'UTR       27773535 chr11:6635370-6635371(-) m6A 3'UTR       24284625//27773535 chr11:6635415-6635416(-) m6A 3'UTR       24284625//27773535 chr11:6635466-6635467(-) m6A 3'UTR       24284625//27773535 chr11:6635664-6635665(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535 chr11:6635688-6635689(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535 chr11:6635793-6635794(-) m6A 3'UTR//CDS       24284625//24981863//27773535 chr11:6635820-6635821(-) m6A CDS       24284625//24981863//27773535 chr11:6636105-6636106(-) m6A CDS//exon       24284625 chr11:6636166-6636167(-) Y CDS//exon       26075521 chr11:6636876-6636877(-) m6A exon//intron       27773535 chr11:6637267-6637268(-) m6A CDS//exon       27773535 chr11:6637871-6637872(-) m6A exon//intron       24284625//25456834//24981863//27773535 chr11:6637876-6637877(-) m6A exon//intron       24284625//25456834//24981863//27773535 chr11:6637991-6637992(-) m6A CDS//exon//intron       27773535 chr11:6638883-6638884(-) m6A 3'UTR//5'UTR//CDS//exon       24284625 chr11:6639837-6639838(-) m6A exon//intron       27773535 chr11:6639886-6639887(-) m6A exon//intron       27773535 chr11:6639910-6639911(-) m6A exon//intron       27773535 chr11:6639986-6639987(-) m6A 3'UTR//exon//intron       27371828 chr11:6639993-6639994(-) m6A 3'UTR//exon//intron       27371828 chr11:6640055-6640056(-) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//27371828 chr11:6640073-6640074(-) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//27371828 chr11:6640110-6640111(-) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24981863//27371828 chr11:6640214-6640215(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//27371828 chr11:6640406-6640407(-) m6A 3'UTR//exon//intron       24284625//24981863//27773535 chr11:6640518-6640519(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//27371828 chr11:6640538-6640539(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//27371828 chr11:6640546-6640547(-) m6A 5'UTR//exon//intron       25456834//24981863//27371828 chr11:6640625-6640626(-) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4521	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	TPP1	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4521
Interactor2: TPP1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).