Basic Information:

  VIRBase ID:  

HHID00016024

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-23c:  MIMAT0018000          RPIA:  NM_144563     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-23c	RPIA
miRBase Accession/Entrez ID	MIMAT0018000	22934
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	RPI//RPIAD

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-23c	rs1395024960 chrX:20017114    C/A rs1449990033 chrX:20017107    T/C rs898099862 chrX:20017112    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RPIA	chr2:89015871(+) A-I      intronic chr2:89015872(+) A-I      intronic chr2:89015860(+) A-I      intronic chr2:89015866(+) A-I      intronic chr2:89015819(+) A-I      intronic chr2:89015856(+) A-I      intronic chr2:89008416(+) A-I      intronic chr2:89008420(+) A-I      intronic chr2:89000017(+) A-I      intronic chr2:89000023(+) A-I      intronic chr2:89009584(+) A-I      intronic chr2:89008456(+) A-I      intronic chr2:89009588(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RPIA	chr2:89015734(+) A-G intron -    22484847 chr2:89015737(+) A-G intron -    22484847 chr2:89015854(+) A-G intron -    22484847 chr2:89032276(+) A-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RPIA	chr2:88991185-88991186(+) m6A 5'UTR       24981863 chr2:88991310-88991311(+) m6A CDS       24981863 chr2:88991319-88991320(+) m6A CDS       24981863 chr2:88991366-88991367(+) m6A CDS       24981863 chr2:88991406-88991407(+) m6A CDS       - chr2:88991490-88991491(+) m6A CDS       - chr2:89049569-89049570(+) m6A CDS       - chr2:89049694-89049695(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-23c	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	RPIA	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-23c
Interactor2: RPIA

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).