Detail Information

Basic Information:


  VIRBase ID:  

HHID00015915

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-23c:           MAP3K1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-23c MAP3K1
miRBase
Accession/Entrez ID		 MIMAT0018000 4214
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MAPKKK1//MEKK//MEKK 1//MEKK1//SRXY6

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-23c
rs1395024960 chrX:20017114    C/A
rs1449990033 chrX:20017107    T/C
rs898099862 chrX:20017112    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MAP3K1
chr5:56186706(+) A-I      intronic
chr5:56160359(+) A-I      intronic
chr5:56150075(+) A-I      intronic
chr5:56150113(+) A-I      intronic
chr5:56157268(+) A-I      intronic
chr5:56160260(+) A-I      intronic
chr5:56160266(+) A-I      intronic
chr5:56160268(+) A-I      intronic
chr5:56160320(+) A-I      intronic
chr5:56160461(+) A-I      intronic
chr5:56161966(+) A-I      intronic
chr5:56161985(+) A-I      intronic
chr5:56162011(+) A-I      intronic
chr5:56164987(+) A-I      intronic
chr5:56150117(+) A-I      intronic
chr5:56150166(+) A-I      intronic
chr5:56150175(+) A-I      intronic
chr5:56186712(+) A-I      intronic
chr5:56150180(+) A-I      intronic
chr5:56150172(+) A-I      intronic
chr5:56150181(+) A-I      intronic
chr5:56156418(+) A-I      intronic
chr5:56186746(+) A-I      intronic
chr5:56186736(+) A-I      intronic
chr5:56156448(+) A-I      intronic
chr5:56156537(+) A-I      intronic
chr5:56156605(+) A-I      intronic
chr5:56157137(+) A-I      intronic
chr5:56157141(+) A-I      intronic
chr5:56186726(+) A-I      intronic
chr5:56157238(+) A-I      intronic
chr5:56164991(+) A-I      intronic
chr5:56182077(+) A-I      intronic
chr5:56182078(+) A-I      intronic
chr5:56120912(+) A-I      intronic
chr5:56182652(+) A-I      intronic
chr5:56186709(+) A-I      intronic
chr5:56182725(+) A-I      intronic
chr5:56186689(+) A-I      intronic
chr5:56186766(+) A-I      intronic
chr5:56186798(+) A-I      intronic
chr5:56186828(+) A-I      intronic
chr5:56120899(+) A-I      intronic
chr5:56182084(+) A-I      intronic
chr5:56130355(+) A-I      intronic
chr5:56130433(+) A-I      intronic
chr5:56136820(+) A-I      intronic
chr5:56146874(+) A-I      intronic
chr5:56150051(+) A-I      intronic
chr5:56150074(+) A-I      intronic
chr5:56185125(+) A-I      intronic
chr5:56182687(+) A-I      intronic
chr5:56182111(+) A-I      intronic
chr5:56182011(+) A-I      intronic
chr5:56160296(+) A-I      intronic
chr5:56165023(+) A-I      intronic
chr5:56182752(+) A-I      intronic
chr5:56186675(+) A-I      intronic
chr5:56182080(+) A-I      intronic
chr5:56182812(+) A-I      intronic
chr5:56182110(+) A-I      intronic
chr5:56160386(+) A-I      intronic
chr5:56136803(+) A-I      intronic
chr5:56164894(+) A-I      intronic
chr5:56182753(+) A-I      intronic
chr5:56162887(+) A-I      intronic
chr5:56164231(+) A-I      intronic
chr5:56160383(+) A-I      intronic
chr5:56186618(+) A-I      intronic
chr5:56160303(+) A-I      intronic
chr5:56185263(+) A-I      intronic
chr5:56162141(+) A-I      intronic
chr5:56160363(+) A-I      intronic
chr5:56182882(+) A-I      intronic
chr5:56182760(+) A-I      intronic
chr5:56162160(+) A-I      intronic
chr5:56162880(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MAP3K1
chr5:56177872(+) A-I exon CDS    21960545
chr5:56130770(+) A-I intron -    21960545
chr5:56165910(+) A-I intron -    21960545
chr5:56182111(+) A-I intron -    21960545
chr5:56160296(+) A-G intron -    22484847
chr5:56160303(+) A-G intron -    22484847
chr5:56160363(+) A-G intron -    22484847
chr5:56160383(+) A-G intron -    22484847
chr5:56160386(+) A-G intron -    22484847
chr5:56164418(+) A-G intron -    22484847
chr5:56182011(+) A-G intron -    22484847
chr5:56182687(+) A-G intron -    22484847
chr5:56182713(+) A-G intron -    22484847
chr5:56182752(+) A-G intron -    22484847
chr5:56182753(+) A-G intron -    22484847
chr5:56182760(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MAP3K1
chr5:56111525-56111526(+) m6A CDS       24209618//24981863//22575960//22608085
chr5:56111566-56111567(+) m6A CDS       24209618//24981863//22575960//22608085
chr5:56111611-56111612(+) m6A CDS       25456834//24981863//22575960//22608085
chr5:56111706-56111707(+) m6A CDS       22608085
chr5:56152448-56152449(+) m6A CDS       27773535
chr5:56152507-56152508(+) m6A CDS       27773535
chr5:56167828-56167829(+) m6A CDS       24981863
chr5:56168495-56168496(+) m6A CDS       24981863
chr5:56177534-56177535(+) m6A CDS       22608085
chr5:56177650-56177651(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr5:56177671-56177672(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr5:56177712-56177713(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr5:56177722-56177723(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr5:56177757-56177758(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr5:56177803-56177804(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr5:56177816-56177817(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr5:56177837-56177838(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr5:56177898-56177899(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr5:56177909-56177910(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr5:56177929-56177930(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr5:56178041-56178042(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr5:56178087-56178088(+) m6A CDS       24284625//25456834//24981863//27773535//22575960//22608085
chr5:56178121-56178122(+) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr5:56178133-56178134(+) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr5:56178139-56178140(+) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr5:56178149-56178150(+) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr5:56178176-56178177(+) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr5:56178218-56178219(+) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr5:56178242-56178243(+) m6A CDS       24284625//24981863//27773535//22608085
chr5:56178283-56178284(+) m6A CDS       24284625//24981863//22608085
chr5:56178357-56178358(+) m6A CDS       22608085
chr5:56179373-56179374(+) m6A CDS       24981863
chr5:56179388-56179389(+) m6A CDS       24981863
chr5:56179405-56179406(+) m6A CDS       24981863
chr5:56179479-56179480(+) m6A CDS       24981863
chr5:56179485-56179486(+) m6A CDS       24981863
chr5:56179502-56179503(+) m6A CDS       24981863
chr5:56180506-56180507(+) m6A CDS       24981863
chr5:56180584-56180585(+) m6A CDS       27773535
chr5:56189437-56189438(+) m6A CDS//exon       22608085
chr5:56189451-56189452(+) m6A CDS//exon       22608085
chr5:56189535-56189536(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr5:56189561-56189562(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr5:56189572-56189573(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr5:56189608-56189609(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr5:56189634-56189635(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr5:56189700-56189701(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085
chr5:56189712-56189713(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085
chr5:56189719-56189720(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085
chr5:56189736-56189737(+) m6A 3'UTR//exon       24284625//24981863//22608085
chr5:56189751-56189752(+) m6A 3'UTR//exon       24284625//24981863//22608085
chr5:56189759-56189760(+) m6A 3'UTR//exon       24284625//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-23c
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
MAP3K1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-23c
Interactor2: MAP3K1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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