Basic Information:

  VIRBase ID:  

HHID00015854

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3074-3p:  MIMAT0015027          GABARAPL3:  NR_028287     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3074-3p	GABARAPL3
miRBase Accession/Entrez ID	MIMAT0015027	23766
Organism	Homo sapiens	Homo sapiens
Category	miRNA	pseudo
Alias	-	ATG8D

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3074-3p	rs1239868123 chr9:95086025    G/A rs1359892054 chr9:95086026    G/A rs527734535 chr9:95086037    G/C rs778461843 chr9:95086024    C/T rs1462524363 chr9:95086042    T/TA rs746151874 chr9:95086044    T/A rs746151874 chr9:95086044    T/C rs746151874 chr9:95086044    T/G rs779347857 chr9:95086041    A/G rs959770203 chr9:95086039    T/G

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3074-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	GABARAPL3	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-3074-3p	Paclitaxel 36314 Drug interaction    RC00008093

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	GABARAPL3	9H-Purine, 6-(ethylthio)-9-beta-D-ribofuranosyl-(8CI)(9CI)       95846 Nicotinamide       936 Flavaspidic acid       8237 2-Chlorodideoxyadenosine       72194 17-Hydroxyjolkinolide B       6712607 Cortivazol       66249 Betamethasone sodium phosphate       65478 4-Arylmaleimide deriv. 8g       6539522 N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-4-[2-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-b]pyridazin-3-yl]pyrimidin-2-amine       6539422 Nilotinib       644241 l-685,458       5479543 6-Benzyloxy-3-methyl-2-hexen-1-ol pyrophosphate       5473028 3-Chloro-4-(4-hydroxyphenyl)-5-(3-bromo-4-hydroxybenzylidene)furan-2(5H)-one       5472908 Presqualene alcohol       5471965 Tetra(N-methyl-2-pyridyl)-porphyrin Chloride       5471231 Austocystin D       5470400 2-Furoyl-7-chloro-3-trifluoromethylquinoxaline-4-oxide       54612695 Isostrychnopentamine A trihydrochloride       54611556 Neolan Yellow BE       54607658 Cristatic acid       5458761 Desoximetasone       5311067 Isotretinoin       5282379 Fialuridine       50313 Peptide PTD       45028373 Phomopsolide E       45028010 5-[(E)-2-(2,6-Diethylphenyl)ethenyl]-N-methylpyridine-3-carboxamide       44418546 6-Benzylthio-4-morpholinopyrazolo[3,4-d]pyrimidine       405659 5-Fluoro-2-(3-Ethoxy-4-hydroxyphenyl)benzothiazole       404994 Elisabatin C       404626 Ethyl-diphenyl-(2-phenylethynyl)phosphanium;iodide       386463 3,8-Dimethyl-1,2-naphthoquinone       373912 Budmunchiamine A       373662 Acridoguanidine       364443 6-beta-Hydroxy-Loganin       341846 Fluphenazine       3372 2-Methyl-2-[4-(Naphthalen-1-Yl)phenoxy]propanoic Acid       327338 Rustaiyan A       324967 Thymolphthalein       31316 Triamcinolone       31307 2,4-Diamino-1,3-diazinane-5-carbonitrile       309160 Nelarabine       3011155 AT 116, benzylamine salt       282523 3-Amino-N-(4-butoxyphenyl)-1H-indazole-1-carboxamide       25199443 1-(1H-Indazol-3-yl)-3-(4-methoxyphenyl)urea       25197519 1-Methyl-3-octadecylimidazolium hexafluorophosphate       24944555 4-[2-[2-(4-Carbamimidoylphenoxy)ethoxy]ethoxy]benzenecarboximidamide;hydrochloride       24205052 [3-(4-Chloro-phenyl)-3-oxo-propenylamino]-acetonitrile       24203420 Chembl4536096       24202660 Arenaemycin E       24199350 Thalphenine chloride       24197663 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide       24180719 Nutlin-3       216345 Dehydroepiandrosterone mustard       198019 Sudan II       18386 Erlotinib       176870 Cyclo(-(R)-b2hPhe-D-Pro-Lys-Phe)       16083382 Fluorophenothiazine dihydrochloride       15773 Irofulven       148189 2'-Deoxyuridine       13712 7-beta-D-Ribofuranosyl-4-oxo-3H-thieno-[3,4-d]pyrimidine       135580413 Unii-BX07F07V62       135564869 4-(p-Methylphenyl)aminopyrazolo[3,4-d]pyrimidin-6-thion       135436400 Dovitinib       135398510 Abiraterone       132971 Isoflupredone       127516 Gersemolide       12000066 Crizotinib       11626560 (S)-N-((S)-1-Cyclohexyl-2-oxo-2-((3aR,7aS)-6-phenethyloctahydro-1H-pyrrolo[2,3-c]pyridin-1-yl)ethyl)-2-(methylamino)propanamide       11503417 Podofilox       10607 Methyl 2-[(2R,4R,6R,10S,12R,13R)-10,13-diacetyloxy-4,15-dimethyl-8-oxo-3,7,17-trioxatetracyclo[12.2.1.16,9.02,4]octadeca-1(16),9(18),14-trien-12-yl]prop-2-enoate       101607568 1,4-benzenediamine (9ci), n-butyl-n'-phenyl-       - 3,3?-thiene-2,5-diylbis(5-methoxy-1h-indole)       - 5,6-ethylenediquino[3,2-b       - 5, 7, 4' trimethoxy flavanone       - 5-benzyl-5,6,7,8-tetrahydro-indeno[1,2-b]indole-9,10-dione       - Cobimetinib (isomer 1)       - duramycin       - imidazole-5-one deri.       - l-cysteine, homopolymer, diphenyltin complex       - methanesulfonothioic acid, s-methyl ester (9ci)       - nsc 708782 incorporated in micelles, 0.45% (w/w) of drug       - progesterone, 11.beta.,17-dihydroxy-6.alpha.-methyl-       - pyrane       -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3074-3p
Interactor2: GABARAPL3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).