Basic Information:

  VIRBase ID:  

HHID00015803

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3074-3p:  MIMAT0015027          TIPRL:  NM_001031800     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3074-3p	TIPRL
miRBase Accession/Entrez ID	MIMAT0015027	261726
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	TIP//TIP41//TIPRL1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3074-3p	rs1239868123 chr9:95086025    G/A rs1359892054 chr9:95086026    G/A rs527734535 chr9:95086037    G/C rs778461843 chr9:95086024    C/T rs1462524363 chr9:95086042    T/TA rs746151874 chr9:95086044    T/A rs746151874 chr9:95086044    T/C rs746151874 chr9:95086044    T/G rs779347857 chr9:95086041    A/G rs959770203 chr9:95086039    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TIPRL	chr1:168164923(+) A-I      intronic chr1:168158865(+) A-I      intronic chr1:168151115(+) A-I      intronic chr1:168158863(+) A-I      intronic chr1:168151198(+) A-I      intronic chr1:168150284(+) A-I      intronic chr1:168158720(+) A-I      intronic chr1:168158108(+) A-I      intronic chr1:168151635(+) A-I      intronic chr1:168166875(+) A-I      intronic chr1:168157988(+) A-I      intronic chr1:168154996(+) A-I      intronic chr1:168158866(+) A-I      intronic chr1:168154990(+) A-I      intronic chr1:168151246(+) A-I      intronic chr1:168154958(+) A-I      intronic chr1:168150537(+) A-I      intronic chr1:168150350(+) A-I      intronic chr1:168150586(+) A-I      intronic chr1:168151668(+) A-I      intronic chr1:168162329(+) A-I      intronic chr1:168166356(+) A-I      intronic chr1:168150483(+) A-I      intronic chr1:168150726(+) A-I      intronic chr1:168162044(+) A-I      intronic chr1:168151809(+) A-I      intronic chr1:168150724(+) A-I      intronic chr1:168151098(+) A-I      intronic chr1:168158767(+) A-I      intronic chr1:168150290(+) A-I      intronic chr1:168151609(+) A-I      intronic chr1:168151113(+) A-I      intronic chr1:168158099(+) A-I      intronic chr1:168166944(+) A-I      intronic chr1:168151835(+) A-I      intronic chr1:168151814(+) A-I      intronic chr1:168151223(+) A-I      intronic chr1:168150733(+) A-I      intronic chr1:168155950(+) A-I      intronic chr1:168157956(+) A-I      intronic chr1:168165064(+) A-I      intronic chr1:168166897(+) A-I      intronic chr1:168166432(+) A-I      intronic chr1:168151813(+) A-I      intronic chr1:168158039(+) A-I      intronic chr1:168151123(+) A-I      intronic chr1:168164977(+) A-I      intronic chr1:168151100(+) A-I      intronic chr1:168150730(+) A-I      intronic chr1:168158713(+) A-I      intronic chr1:168156951(+) A-I      intronic chr1:168150685(+) A-I      intronic chr1:168151122(+) A-I      intronic chr1:168150579(+) A-I      intronic chr1:168150136(+) A-I      intronic chr1:168151272(+) A-I      intronic chr1:168150632(+) A-I      intronic chr1:168150198(+) A-I      intronic chr1:168150531(+) A-I      intronic chr1:168166458(+) A-I      intronic chr1:168151044(+) A-I      intronic chr1:168151708(+) A-I      intronic chr1:168166414(+) A-I      intronic chr1:168150252(+) A-I      intronic chr1:168166283(+) A-I      intronic chr1:168150321(+) A-I      intronic chr1:168166858(+) A-I      intronic chr1:168151234(+) A-I      intronic chr1:168166452(+) A-I      intronic chr1:168150712(+) A-I      intronic chr1:168151137(+) A-I      intronic chr1:168160869(+) A-I      intronic chr1:168167000(+) A-I      intronic chr1:168151289(+) A-I      intronic chr1:168166884(+) A-I      intronic chr1:168151756(+) A-I      intronic chr1:168150670(+) A-I      intronic chr1:168150360(+) A-I      intronic chr1:168164976(+) A-I      intronic chr1:168151182(+) A-I      intronic chr1:168166288(+) A-I      intronic chr1:168158764(+) A-I      intronic chr1:168151043(+) A-I      intronic chr1:168166099(+) A-I      intronic chr1:168151799(+) A-I      intronic chr1:168150732(+) A-I      intronic chr1:168150692(+) A-I      intronic chr1:168150507(+) A-I      intronic chr1:168150589(+) A-I      intronic chr1:168152905(+) A-I      intronic chr1:168150244(+) A-I      intronic chr1:168160902(+) A-I      intronic chr1:168150182(+) A-I      intronic chr1:168151743(+) A-I      intronic chr1:168166465(+) A-I      intronic chr1:168151217(+) A-I      intronic chr1:168151744(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TIPRL	chr1:168169847(+) A-T intron -    22484847 chr1:168150244(+) A-G intron -    22484847 chr1:168150507(+) A-G intron -    22484847 chr1:168150531(+) A-G intron -    22484847 chr1:168150579(+) A-G intron -    22484847 chr1:168151122(+) A-G intron -    22484847 chr1:168151182(+) A-G intron -    22484847 chr1:168151217(+) A-G intron -    22484847 chr1:168158039(+) A-G intron -    22484847 chr1:168160869(+) A-G intron -    22484847 chr1:168165064(+) A-G intron -    22484847 chr1:168166288(+) A-G intron -    22484847 chr1:168166461(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TIPRL	chr1:168148249-168148250(+) m6A 5'UTR       24284625//24981863 chr1:168154028-168154029(+) m6A CDS       24981863 chr1:168154049-168154050(+) m6A CDS       24981863 chr1:168154062-168154063(+) m6A CDS       24981863 chr1:168165867-168165868(+) m6A CDS       24284625//24981863 chr1:168168165-168168166(+) m6A CDS       24284625//24981863 chr1:168169166-168169167(+) m6A CDS       24284625//24981863//27773535 chr1:168169255-168169256(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr1:168169323-168169324(+) m6A 3'UTR       24284625//24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3074-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	TIPRL	Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3074-3p
Interactor2: TIPRL

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).