Basic Information:

  VIRBase ID:  

HHID00015766

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3074-3p:  MIMAT0015027          PAQR3:  NR_146465     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3074-3p	PAQR3
miRBase Accession/Entrez ID	MIMAT0015027	152559
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	RKTG

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3074-3p	rs1239868123 chr9:95086025    G/A rs1359892054 chr9:95086026    G/A rs527734535 chr9:95086037    G/C rs778461843 chr9:95086024    C/T rs1462524363 chr9:95086042    T/TA rs746151874 chr9:95086044    T/A rs746151874 chr9:95086044    T/C rs746151874 chr9:95086044    T/G rs779347857 chr9:95086041    A/G rs959770203 chr9:95086039    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PAQR3	chr4:79839157(-) A-I      3'UTR chr4:79839152(-) A-I      3'UTR chr4:79839151(-) A-I      3'UTR chr4:79839144(-) A-I      3'UTR chr4:79839143(-) A-I      3'UTR chr4:79839194(-) A-I      3'UTR chr4:79839198(-) A-I      3'UTR chr4:79839158(-) A-I      3'UTR chr4:79839131(-) A-I      3'UTR chr4:79814994(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PAQR3	chr4:79832156-79832157(-) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr4:79832263-79832264(-) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr4:79832282-79832283(-) m6A 3'UTR//intron       24284625//24209618//24981863//22608085 chr4:79832353-79832354(-) m6A 3'UTR//intron       24284625//24981863//22608085 chr4:79832635-79832636(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr4:79832668-79832669(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr4:79832873-79832874(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr4:79832993-79832994(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr4:79833121-79833122(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr4:79833130-79833131(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr4:79833220-79833221(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr4:79833240-79833241(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr4:79860422-79860423(-) m6A 5'UTR       24209618//27371828//27773536 chr4:79860492-79860493(-) m6A 5'UTR       24209618//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3074-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	PAQR3	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3074-3p
Interactor2: PAQR3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).