Basic Information:

  VIRBase ID:  

HHID00015762

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3074-3p:  MIMAT0015027          ARL6IP6:  NM_152522     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3074-3p	ARL6IP6
miRBase Accession/Entrez ID	MIMAT0015027	151188
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AIP-6//AIP6//PFAAP1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3074-3p	rs1239868123 chr9:95086025    G/A rs1359892054 chr9:95086026    G/A rs527734535 chr9:95086037    G/C rs778461843 chr9:95086024    C/T rs1462524363 chr9:95086042    T/TA rs746151874 chr9:95086044    T/A rs746151874 chr9:95086044    T/C rs746151874 chr9:95086044    T/G rs779347857 chr9:95086041    A/G rs959770203 chr9:95086039    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ARL6IP6	chr2:153604268(+) A-I      intronic chr2:153614730(+) A-I      intronic chr2:153614686(+) A-I      intronic chr2:153614692(+) A-I      intronic chr2:153614693(+) A-I      intronic chr2:153614731(+) A-I      intronic chr2:153614742(+) A-I      intronic chr2:153614691(+) A-I      intronic chr2:153614713(+) A-I      intronic chr2:153604347(+) A-I      intronic chr2:153604353(+) A-I      intronic chr2:153606802(+) A-I      intronic chr2:153606947(+) A-I      intronic chr2:153609567(+) A-I      intronic chr2:153606773(+) A-I      intronic chr2:153596716(+) A-I      intronic chr2:153604194(+) A-I      intronic chr2:153596710(+) A-I      intronic chr2:153596691(+) A-I      intronic chr2:153606875(+) A-I      intronic chr2:153591025(+) A-I      intronic chr2:153602593(+) A-I      intronic chr2:153604190(+) A-I      intronic chr2:153606817(+) A-I      intronic chr2:153606787(+) A-I      intronic chr2:153609570(+) A-I      intronic chr2:153604223(+) A-I      intronic chr2:153606886(+) A-I      intronic chr2:153606721(+) A-I      intronic chr2:153604151(+) A-I      intronic chr2:153606962(+) A-I      intronic chr2:153591055(+) A-I      intronic chr2:153596803(+) A-I      intronic chr2:153604495(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ARL6IP6	chr2:153591025(+) A-G intron -    22484847 chr2:153602593(+) A-G intron -    22484847 chr2:153604151(+) A-G intron -    22484847 chr2:153604189(+) A-G intron -    22484847 chr2:153604190(+) A-G intron -    22484847 chr2:153604223(+) A-G intron -    22484847 chr2:153606721(+) A-G intron -    22484847 chr2:153606817(+) A-G intron -    22484847 chr2:153606823(+) A-G intron -    22484847 chr2:153606940(+) A-G intron -    22484847 chr2:153609663(+) T-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARL6IP6	chr2:153574411-153574412(+) m6A exon       25456834 chr2:153574580-153574581(+) m6A 5'UTR//intron       27773535 chr2:153574617-153574618(+) m6A 5'UTR//intron       27773535 chr2:153574658-153574659(+) m6A 5'UTR//intron       27773535 chr2:153574690-153574691(+) m1A 5'UTR//intron       26863196//26863410 chr2:153574700-153574701(+) m6A 5'UTR//intron       24981863//27773535 chr2:153574748-153574749(+) m6A 5'UTR//intron       27773536 chr2:153616263-153616264(+) m6A 3'UTR//CDS//exon       24284625 chr2:153616272-153616273(+) m6A 3'UTR//CDS//exon       24284625 chr2:153616354-153616355(+) m6A 3'UTR//exon       24284625//24981863 chr2:153616383-153616384(+) m6A 3'UTR//exon       24284625//24981863 chr2:153616439-153616440(+) m6A 3'UTR//exon       24284625//24981863 chr2:153616447-153616448(+) m6A 3'UTR//exon       24284625//24981863 chr2:153616503-153616504(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3074-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	ARL6IP6	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3074-3p
Interactor2: ARL6IP6

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).