Basic Information:

  VIRBase ID:  

HHID00015717

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3074-3p:  MIMAT0015027          TUBGCP5:  NM_001354374     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3074-3p	TUBGCP5
miRBase Accession/Entrez ID	MIMAT0015027	114791
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GCP5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3074-3p	rs1239868123 chr9:95086025    G/A rs1359892054 chr9:95086026    G/A rs527734535 chr9:95086037    G/C rs778461843 chr9:95086024    C/T rs1462524363 chr9:95086042    T/TA rs746151874 chr9:95086044    T/A rs746151874 chr9:95086044    T/C rs746151874 chr9:95086044    T/G rs779347857 chr9:95086041    A/G rs959770203 chr9:95086039    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TUBGCP5	chr15:22843271(+) A-I      intronic chr15:22843287(+) A-I      intronic chr15:22860530(+) A-I      intronic chr15:22860533(+) A-I      intronic chr15:22865858(+) A-I      intronic chr15:22860467(+) A-I      intronic chr15:22860522(+) A-I      intronic chr15:22860487(+) A-I      intronic chr15:22860496(+) A-I      intronic chr15:22860493(+) A-I      intronic chr15:22860512(+) A-I      intronic chr15:22843189(+) A-I      intronic chr15:22847400(+) A-I      intronic chr15:22847887(+) A-I      intronic chr15:22847980(+) A-I      intronic chr15:22847986(+) A-I      intronic chr15:22847990(+) A-I      intronic chr15:22847991(+) A-I      intronic chr15:22851898(+) A-I      intronic chr15:22852240(+) A-I      intronic chr15:22852582(+) A-I      intronic chr15:22852594(+) A-I      intronic chr15:22864705(+) A-I      intronic chr15:22864704(+) A-I      intronic chr15:22864653(+) A-I      intronic chr15:22864606(+) A-I      intronic chr15:22843670(+) A-I      intronic chr15:22853379(+) A-I      intronic chr15:22864531(+) A-I      intronic chr15:22859834(+) A-I      intronic chr15:22861209(+) A-I      intronic chr15:22861197(+) A-I      intronic chr15:22843629(+) A-I      intronic chr15:22860537(+) A-I      intronic chr15:22860523(+) A-I      intronic chr15:22860160(+) A-I      intronic chr15:22860147(+) A-I      intronic chr15:22843299(+) A-I      intronic chr15:22843778(+) A-I      intronic chr15:22847392(+) A-I      intronic chr15:22843628(+) A-I      intronic chr15:22873085(+) A-I      intronic chr15:22860048(+) A-I      intronic chr15:22843668(+) A-I      intronic chr15:22865902(+) A-I      intronic chr15:22848069(+) A-I      intronic chr15:22859686(+) A-I      intronic chr15:22843347(+) A-I      intronic chr15:22857805(+) A-I      intronic chr15:22860133(+) A-I      intronic chr15:22841553(+) A-I      intronic chr15:22842822(+) A-I      intronic chr15:22842925(+) A-I      intronic chr15:22842960(+) A-I      intronic chr15:22857644(+) A-I      intronic chr15:22847425(+) A-I      intronic chr15:22852976(+) A-I      intronic chr15:22842968(+) A-I      intronic chr15:22843039(+) A-I      intronic chr15:22843076(+) A-I      intronic chr15:22843045(+) A-I      intronic chr15:22843077(+) A-I      intronic chr15:22843118(+) A-I      intronic chr15:22857643(+) A-I      intronic chr15:22853387(+) A-I      intronic chr15:22843332(+) A-I      intronic chr15:22843786(+) A-I      intronic chr15:22852996(+) A-I      intronic chr15:22843819(+) A-I      intronic chr15:22852983(+) A-I      intronic chr15:22852974(+) A-I      intronic chr15:22845305(+) A-I      intronic chr15:22864515(+) A-I      intronic chr15:22852971(+) A-I      intronic chr15:22873081(+) A-I      intronic chr15:22865741(+) A-I      intronic chr15:22864716(+) A-I      intronic chr15:22845335(+) A-I      intronic chr15:22873529(+) A-I      3'UTR chr15:22873589(+) A-I      3'UTR chr15:22873543(+) A-I      3'UTR chr15:22843350(+) A-I      intronic chr15:22847989(+) A-I      intronic chr15:22871996(+) A-I      intronic chr15:22843270(+) A-I      intronic chr15:22843309(+) A-I      intronic chr15:22851824(+) A-I      intronic chr15:22843817(+) A-I      intronic chr15:22864615(+) A-I      intronic chr15:22845327(+) A-I      intronic chr15:22842879(+) A-I      intronic chr15:22852055(+) A-I      intronic chr15:22865903(+) A-I      intronic chr15:22857637(+) A-I      intronic chr15:22848137(+) A-I      intronic chr15:22843223(+) A-I      intronic chr15:22843750(+) A-I      intronic chr15:22851808(+) A-I      intronic chr15:22864687(+) A-I      intronic chr15:22835045(+) A-I      intronic chr15:22848061(+) A-I      intronic chr15:22853315(+) A-I      intronic chr15:22843094(+) A-I      intronic chr15:22847359(+) A-I      intronic chr15:22864614(+) A-I      intronic chr15:22843263(+) A-I      intronic chr15:22843441(+) A-I      intronic chr15:22864770(+) A-I      intronic chr15:22843574(+) A-I      intronic chr15:22853380(+) A-I      intronic chr15:22865724(+) A-I      intronic chr15:22857844(+) A-I      intronic chr15:22852189(+) A-I      intronic chr15:22857845(+) A-I      intronic chr15:22872880(+) A-I      intronic chr15:22843013(+) A-I      intronic chr15:22843070(+) A-I      intronic chr15:22843671(+) A-I      intronic chr15:22872929(+) A-I      intronic chr15:22864914(+) A-I      intronic chr15:22872924(+) A-I      intronic chr15:22843201(+) A-I      intronic chr15:22842956(+) A-I      intronic chr15:22848028(+) A-I      intronic chr15:22852119(+) A-I      intronic chr15:22859805(+) A-I      intronic chr15:22845373(+) A-I      intronic chr15:22843575(+) A-I      intronic chr15:22843387(+) A-I      intronic chr15:22865933(+) A-I      intronic chr15:22841587(+) A-I      intronic chr15:22847894(+) A-I      intronic chr15:22857648(+) A-I      intronic chr15:22861426(+) A-I      intronic chr15:22843231(+) A-I      intronic chr15:22843754(+) A-I      intronic chr15:22861009(+) A-I      intronic chr15:22842887(+) A-I      intronic chr15:22843228(+) A-I      intronic chr15:22872997(+) A-I      intronic chr15:22848136(+) A-I      intronic chr15:22864664(+) A-I      intronic chr15:22864519(+) A-I      intronic chr15:22865854(+) A-I      intronic chr15:22847893(+) A-I      intronic chr15:22843682(+) A-I      intronic chr15:22847988(+) A-I      intronic chr15:22857874(+) A-I      intronic chr15:22843591(+) A-I      intronic chr15:22865725(+) A-I      intronic chr15:22852051(+) A-I      intronic chr15:22843665(+) A-I      intronic chr15:22864616(+) A-I      intronic chr15:22847420(+) A-I      intronic chr15:22843718(+) A-I      intronic chr15:22857842(+) A-I      intronic chr15:22865778(+) A-I      intronic chr15:22843333(+) A-I      intronic chr15:22860433(+) A-I      intronic chr15:22843669(+) A-I      intronic chr15:22843732(+) A-I      intronic chr15:22860464(+) A-I      intronic chr15:22865915(+) A-I      intronic chr15:22845365(+) A-I      intronic chr15:22857789(+) A-I      intronic chr15:22842839(+) A-I      intronic chr15:22843677(+) A-I      intronic chr15:22848070(+) A-I      intronic chr15:22873474(+) A-I      3'UTR chr15:22873583(+) A-I      3'UTR chr15:22873411(+) A-I      3'UTR chr15:22873417(+) A-I      3'UTR chr15:22873565(+) A-I      3'UTR chr15:22873551(+) A-I      3'UTR chr15:22873690(+) A-I      3'UTR chr15:22873621(+) A-I      3'UTR chr15:22873607(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TUBGCP5	chr15:22873690(+) A-I exon 3'UTR    19478186 chr15:22843682(+) A-I intron -    22327324 chr15:22843228(+) A-G intron -    22484847 chr15:22843628(+) A-G intron -    22484847 chr15:22843629(+) A-G intron -    22484847 chr15:22843668(+) A-G intron -    22484847 chr15:22843682(+) A-G intron -    22484847 chr15:22843732(+) A-G intron -    22484847 chr15:22852189(+) A-G intron -    22484847 chr15:22864519(+) A-G intron -    22484847 chr15:22864664(+) A-G intron -    22484847 chr15:22865933(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TUBGCP5	chr15:22833522-22833523(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr15:22833624-22833625(+) m6A CDS       24981863 chr15:22833648-22833649(+) m6A CDS       24981863 chr15:22840318-22840319(+) m6A CDS       27773535 chr15:22841092-22841093(+) m6A CDS       24981863//27773535 chr15:22841110-22841111(+) m6A CDS       24981863//27773535 chr15:22842102-22842103(+) m6A CDS       24981863 chr15:22855099-22855100(+) m6A CDS//exon       24981863 chr15:22855197-22855198(+) m6A CDS//exon       24981863 chr15:22867479-22867480(+) m6A CDS       24981863 chr15:22867509-22867510(+) m6A CDS       24981863 chr15:22867514-22867515(+) m6A CDS       24981863 chr15:22867533-22867534(+) m6A CDS       24981863 chr15:22867545-22867546(+) m6A CDS       24981863 chr15:22867554-22867555(+) m6A CDS       24981863 chr15:22867607-22867608(+) m6A CDS       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3074-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	TUBGCP5	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3074-3p
Interactor2: TUBGCP5

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).