Basic Information:

  VIRBase ID:  

HHID00015712

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3074-3p:  MIMAT0015027          MMGT1:  NM_173470     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3074-3p	MMGT1
miRBase Accession/Entrez ID	MIMAT0015027	93380
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	EMC5//TMEM32

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3074-3p	rs1239868123 chr9:95086025    G/A rs1359892054 chr9:95086026    G/A rs527734535 chr9:95086037    G/C rs778461843 chr9:95086024    C/T rs1462524363 chr9:95086042    T/TA rs746151874 chr9:95086044    T/A rs746151874 chr9:95086044    T/C rs746151874 chr9:95086044    T/G rs779347857 chr9:95086041    A/G rs959770203 chr9:95086039    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MMGT1	chrX:135052992(-) A-I      intronic chrX:135048677(-) A-I      intronic chrX:135053064(-) A-I      intronic chrX:135053054(-) A-I      intronic chrX:135053016(-) A-I      intronic chrX:135052436(-) A-I      intronic chrX:135051665(-) A-I      intronic chrX:135050818(-) A-I      intronic chrX:135052388(-) A-I      intronic chrX:135051677(-) A-I      intronic chrX:135052352(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MMGT1	chrX:135044511-135044512(-) m6A 3'UTR       - chrX:135045337-135045338(-) m6A 3'UTR       24981863//27773535 chrX:135045360-135045361(-) m6A 3'UTR       24981863//27773535 chrX:135045539-135045540(-) Tm 3'UTR       - chrX:135047073-135047074(-) m6A 3'UTR       24284625//24981863//26404942 chrX:135047116-135047117(-) m6A 3'UTR       24284625//24981863//26404942 chrX:135047151-135047152(-) m6A 3'UTR       24284625//24981863//26404942 chrX:135047156-135047157(-) m6A 3'UTR       24284625//24981863//26404942 chrX:135047203-135047204(-) m6A CDS       24284625//24981863 chrX:135047246-135047247(-) m6A CDS       24284625 chrX:135049559-135049560(-) m6A CDS       24284625 chrX:135049578-135049579(-) m6A CDS       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3074-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	MMGT1	Exosome Blood     - Nucleolus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3074-3p
Interactor2: MMGT1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).