Basic Information:

  VIRBase ID:  

HHID00015679

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3074-3p:  MIMAT0015027          EIF2A:  NM_001319045     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3074-3p	EIF2A
miRBase Accession/Entrez ID	MIMAT0015027	83939
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CDA02//EIF-2A//MST089//MSTP004//MSTP089

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3074-3p	rs1239868123 chr9:95086025    G/A rs1359892054 chr9:95086026    G/A rs527734535 chr9:95086037    G/C rs778461843 chr9:95086024    C/T rs1462524363 chr9:95086042    T/TA rs746151874 chr9:95086044    T/A rs746151874 chr9:95086044    T/C rs746151874 chr9:95086044    T/G rs779347857 chr9:95086041    A/G rs959770203 chr9:95086039    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EIF2A	chr3:150288759(+) A-I      intronic chr3:150289107(+) A-I      intronic chr3:150291143(+) A-I      intronic chr3:150295261(+) A-I      intronic chr3:150288794(+) A-I      intronic chr3:150288774(+) A-I      intronic chr3:150279675(+) A-I      intronic chr3:150303175(+) A-I      3'UTR chr3:150279695(+) A-I      intronic chr3:150279701(+) A-I      intronic chr3:150303156(+) A-I      3'UTR chr3:150303148(+) A-I      3'UTR chr3:150279726(+) A-I      intronic chr3:150279729(+) A-I      intronic chr3:150279735(+) A-I      intronic chr3:150279807(+) A-I      intronic chr3:150279936(+) A-I      intronic chr3:150279998(+) A-I      intronic chr3:150280022(+) A-I      intronic chr3:150280047(+) A-I      intronic chr3:150280048(+) A-I      intronic chr3:150280049(+) A-I      intronic chr3:150280088(+) A-I      intronic chr3:150288664(+) A-I      intronic chr3:150288689(+) A-I      intronic chr3:150288693(+) A-I      intronic chr3:150288696(+) A-I      intronic chr3:150288733(+) A-I      intronic chr3:150288762(+) A-I      intronic chr3:150288785(+) A-I      intronic chr3:150288816(+) A-I      intronic chr3:150288818(+) A-I      intronic chr3:150288833(+) A-I      intronic chr3:150288991(+) A-I      intronic chr3:150289007(+) A-I      intronic chr3:150289093(+) A-I      intronic chr3:150289187(+) A-I      intronic chr3:150289188(+) A-I      intronic chr3:150289189(+) A-I      intronic chr3:150293656(+) A-I      intronic chr3:150293661(+) A-I      intronic chr3:150293680(+) A-I      intronic chr3:150293756(+) A-I      intronic chr3:150293760(+) A-I      intronic chr3:150280062(+) A-I      intronic chr3:150269258(+) A-I      intronic chr3:150271407(+) A-I      intronic chr3:150271459(+) A-I      intronic chr3:150271460(+) A-I      intronic chr3:150273443(+) A-I      intronic chr3:150273474(+) A-I      intronic chr3:150279110(+) A-I      intronic chr3:150279155(+) A-I      intronic chr3:150279280(+) A-I      intronic chr3:150279284(+) A-I      intronic chr3:150279633(+) A-I      intronic chr3:150279647(+) A-I      intronic chr3:150303186(+) A-I      3'UTR chr3:150303185(+) A-I      3'UTR chr3:150303179(+) A-I      3'UTR chr3:150303297(+) A-I      3'UTR chr3:150303298(+) A-I      3'UTR chr3:150302865(+) A-I      3'UTR chr3:150302941(+) A-I      3'UTR chr3:150303051(+) A-I      3'UTR chr3:150303052(+) A-I      3'UTR chr3:150303057(+) A-I      3'UTR chr3:150303074(+) A-I      3'UTR chr3:150303172(+) A-I      3'UTR chr3:150303212(+) A-I      3'UTR chr3:150295460(+) A-I      intronic chr3:150279109(+) A-I      intronic chr3:150271387(+) A-I      intronic chr3:150271412(+) A-I      intronic chr3:150288982(+) A-I      intronic chr3:150271335(+) A-I      intronic chr3:150279789(+) A-I      intronic chr3:150289112(+) A-I      intronic chr3:150297235(+) A-I      intronic chr3:150271289(+) A-I      intronic chr3:150271418(+) A-I      intronic chr3:150295482(+) A-I      intronic chr3:150289110(+) A-I      intronic chr3:150290584(+) A-I      intronic chr3:150270958(+) A-I      intronic chr3:150279685(+) A-I      intronic chr3:150273421(+) A-I      intronic chr3:150273420(+) A-I      intronic chr3:150290522(+) A-I      intronic chr3:150279639(+) A-I      intronic chr3:150290432(+) A-I      intronic chr3:150270903(+) A-I      intronic chr3:150277378(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EIF2A	chr3:150286003-150286004(+) m6A 3'UTR//CDS//exon       24284625 chr3:150286026-150286027(+) m6A 3'UTR//CDS       24284625 chr3:150289872-150289873(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:150289910-150289911(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:150289949-150289950(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:150289975-150289976(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:150289982-150289983(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:150289994-150289995(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:150290205-150290206(+) m6A 3'UTR//CDS       24284625//24981863//27773535 chr3:150290249-150290250(+) m6A 3'UTR//CDS       24284625//24981863//27773535 chr3:150290273-150290274(+) m6A 3'UTR//CDS       24284625//24981863//27773535 chr3:150290294-150290295(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535 chr3:150293446-150293447(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr3:150293464-150293465(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr3:150293498-150293499(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr3:150299468-150299469(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr3:150299495-150299496(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr3:150299507-150299508(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr3:150299522-150299523(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr3:150300988-150300989(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr3:150301003-150301004(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr3:150301015-150301016(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr3:150301033-150301034(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr3:150301653-150301654(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr3:150301960-150301961(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3074-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	EIF2A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352 Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3074-3p
Interactor2: EIF2A

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).