Basic Information:

  VIRBase ID:  

HHID00015666

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3074-3p:  MIMAT0015027          LIMD2:  NM_030576     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3074-3p	LIMD2
miRBase Accession/Entrez ID	MIMAT0015027	80774
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3074-3p	rs1239868123 chr9:95086025    G/A rs1359892054 chr9:95086026    G/A rs527734535 chr9:95086037    G/C rs778461843 chr9:95086024    C/T rs1462524363 chr9:95086042    T/TA rs746151874 chr9:95086044    T/A rs746151874 chr9:95086044    T/C rs746151874 chr9:95086044    T/G rs779347857 chr9:95086041    A/G rs959770203 chr9:95086039    T/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LIMD2	chr17:61773277-61773278(-) m6A 3'UTR       27371828 chr17:61773338-61773339(-) m6A 3'UTR       25456834//27371828 chr17:61773351-61773352(-) m6A 3'UTR       25456834//27371828 chr17:61773421-61773422(-) m6A 3'UTR       24284625//25456834//27371828 chr17:61773466-61773467(-) m6A 3'UTR       24284625//25456834//27371828 chr17:61773514-61773515(-) m6A 3'UTR       24209618//25456834//27773535//27371828 chr17:61773520-61773521(-) m6A 3'UTR       24209618//25456834//27773535//27371828 chr17:61773674-61773675(-) m6A 3'UTR       27773535//27371828 chr17:61773714-61773715(-) m6A 3'UTR       24209618//25456834//24981863//27773535//27371828 chr17:61773800-61773801(-) m6A 3'UTR       24209618//25456834//27773535//27371828 chr17:61773832-61773833(-) m6A 3'UTR       24209618//25456834//27773535//27371828 chr17:61773842-61773843(-) m6A 3'UTR       24209618//25456834//27773535//27371828 chr17:61773889-61773890(-) m6A 3'UTR       24209618//25456834//24981863//27371828 chr17:61773958-61773959(-) m6A 3'UTR       25456834//27371828 chr17:61773988-61773989(-) m6A 3'UTR       25456834//27371828 chr17:61774016-61774017(-) m6A 3'UTR       25456834//27371828 chr17:61774045-61774046(-) m6A 3'UTR       25456834//27371828 chr17:61774312-61774313(-) m6A 3'UTR       25456834//27371828 chr17:61774379-61774380(-) m6A 3'UTR       25456834//24981863//27371828 chr17:61774385-61774386(-) m6A 3'UTR       25456834//24981863//27371828 chr17:61774402-61774403(-) m6A 3'UTR       25456834//24981863//27371828 chr17:61774458-61774459(-) m6A 3'UTR       25456834//24981863//27371828//27773536 chr17:61774479-61774480(-) m6A 3'UTR       25456834//24981863//27371828//27773536 chr17:61774497-61774498(-) m6A 3'UTR       25456834//24981863//27371828 chr17:61774527-61774528(-) m6A 3'UTR       25456834//24981863//27371828 chr17:61774535-61774536(-) m6A 3'UTR       25456834//24981863//27371828 chr17:61774556-61774557(-) m6A 3'UTR       25456834//24981863//27371828 chr17:61775193-61775194(-) m6A 3'UTR//exon       28052920//27773535 chr17:61775328-61775329(-) m6A 3'UTR//exon       25456834//24981863//28052920//26404942//27773536 chr17:61775338-61775339(-) m6A 3'UTR//exon       25456834//24981863//28052920//26404942//27773536 chr17:61775474-61775475(-) m6A 3'UTR//exon       28052920 chr17:61775536-61775537(-) m6A 3'UTR//exon       28052920//27773536 chr17:61775644-61775645(-) m6A 3'UTR//exon       25456834//27773535//27773536 chr17:61775714-61775715(-) m6A 3'UTR//exon       25456834//27773536 chr17:61775758-61775759(-) m6A 3'UTR//exon//intron       25456834//24981863//27773536 chr17:61775782-61775783(-) m6A 3'UTR//exon//intron       25456834//24981863//27773536 chr17:61775933-61775934(-) m6A CDS//exon       25456834 chr17:61776246-61776247(-) m6A 5'UTR//CDS//exon//intron       27773536 chr17:61776267-61776268(-) m6A 5'UTR//CDS//exon//intron       27773536 chr17:61776582-61776583(-) m6A exon//intron       27773536 chr17:61776706-61776707(-) m6A 5'UTR//exon       25456834//27773536 chr17:61776838-61776839(-) m6A exon//intron       27773536 chr17:61776895-61776896(-) m6A exon//intron       27773536 chr17:61777351-61777352(-) m6A exon//intron       27371828//27773536 chr17:61777423-61777424(-) m6A 5'UTR//exon//intron       27371828//27773536 chr17:61777483-61777484(-) m6A 5'UTR//exon//intron       25456834//27371828 chr17:61777834-61777835(-) m6A 5'UTR//intron       25456834//27371828 chr17:61777927-61777928(-) m6A 5'UTR//intron       25456834//27371828 chr17:61778032-61778033(-) m6A 5'UTR//intron       27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3074-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	LIMD2	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3074-3p
Interactor2: LIMD2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).