Basic Information:

  VIRBase ID:  

HHID00015604

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3074-3p:  MIMAT0015027          CDC37L1:  NM_017913     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3074-3p	CDC37L1
miRBase Accession/Entrez ID	MIMAT0015027	55664
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CDC37B//HARC

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3074-3p	rs1239868123 chr9:95086025    G/A rs1359892054 chr9:95086026    G/A rs527734535 chr9:95086037    G/C rs778461843 chr9:95086024    C/T rs1462524363 chr9:95086042    T/TA rs746151874 chr9:95086044    T/A rs746151874 chr9:95086044    T/C rs746151874 chr9:95086044    T/G rs779347857 chr9:95086041    A/G rs959770203 chr9:95086039    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDC37L1	chr9:4693277(+) A-I      intronic chr9:4693403(+) A-I      intronic chr9:4694179(+) A-I      intronic chr9:4694183(+) A-I      intronic chr9:4694184(+) A-I      intronic chr9:4694314(+) A-I      intronic chr9:4694611(+) A-I      intronic chr9:4695284(+) A-I      intronic chr9:4695335(+) A-I      intronic chr9:4695510(+) A-I      intronic chr9:4695511(+) A-I      intronic chr9:4695749(+) A-I      intronic chr9:4695773(+) A-I      intronic chr9:4695958(+) A-I      intronic chr9:4695966(+) A-I      intronic chr9:4694763(+) A-I      intronic chr9:4681458(+) A-I      intronic chr9:4681459(+) A-I      intronic chr9:4681484(+) A-I      intronic chr9:4681529(+) A-I      intronic chr9:4681533(+) A-I      intronic chr9:4681606(+) A-I      intronic chr9:4682457(+) A-I      intronic chr9:4682526(+) A-I      intronic chr9:4682534(+) A-I      intronic chr9:4682564(+) A-I      intronic chr9:4682599(+) A-I      intronic chr9:4684119(+) A-I      intronic chr9:4684137(+) A-I      intronic chr9:4684163(+) A-I      intronic chr9:4684190(+) A-I      intronic chr9:4684270(+) A-I      intronic chr9:4687558(+) A-I      intronic chr9:4688067(+) A-I      intronic chr9:4688139(+) A-I      intronic chr9:4688180(+) A-I      intronic chr9:4688197(+) A-I      intronic chr9:4693205(+) A-I      intronic chr9:4693260(+) A-I      intronic chr9:4695285(+) A-I      intronic chr9:4695774(+) A-I      intronic chr9:4681575(+) A-I      intronic chr9:4694791(+) A-I      intronic chr9:4694343(+) A-I      intronic chr9:4688129(+) A-I      intronic chr9:4684031(+) A-I      intronic chr9:4695204(+) A-I      intronic chr9:4687605(+) A-I      intronic chr9:4695612(+) A-I      intronic chr9:4693204(+) A-I      intronic chr9:4695917(+) A-I      intronic chr9:4694102(+) A-I      intronic chr9:4687421(+) A-I      intronic chr9:4694300(+) A-I      intronic chr9:4687564(+) A-I      intronic chr9:4696466(+) A-I      intronic chr9:4694101(+) A-I      intronic chr9:4694790(+) A-I      intronic chr9:4695264(+) A-I      intronic chr9:4693240(+) A-I      intronic chr9:4695208(+) A-I      intronic chr9:4688117(+) A-I      intronic chr9:4694289(+) A-I      intronic chr9:4681568(+) A-I      intronic chr9:4695530(+) A-I      intronic chr9:4694785(+) A-I      intronic chr9:4696046(+) A-I      intronic chr9:4693222(+) A-I      intronic chr9:4695757(+) A-I      intronic chr9:4694751(+) A-I      intronic chr9:4694618(+) A-I      intronic chr9:4693363(+) A-I      intronic chr9:4687580(+) A-I      intronic chr9:4694159(+) A-I      intronic chr9:4687445(+) A-I      intronic chr9:4694340(+) A-I      intronic chr9:4695697(+) A-I      intronic chr9:4695759(+) A-I      intronic chr9:4694174(+) A-I      intronic chr9:4693385(+) A-I      intronic chr9:4682224(+) A-I      intronic chr9:4694180(+) A-I      intronic chr9:4687432(+) A-I      intronic chr9:4695855(+) A-I      intronic chr9:4693418(+) A-I      intronic chr9:4695586(+) A-I      intronic chr9:4688075(+) A-I      intronic chr9:4694173(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CDC37L1	chr9:4702216(+) A-I intron -    21960545 chr9:4694149(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDC37L1	chr9:4679658-4679659(+) m6A 5'UTR       24981863 chr9:4679750-4679751(+) m6A 5'UTR//exon       24981863 chr9:4679765-4679766(+) m6A 5'UTR//exon       24981863 chr9:4679772-4679773(+) m6A CDS//exon       24981863 chr9:4679793-4679794(+) m6A CDS//exon       24981863 chr9:4684974-4684975(+) m6A CDS//exon       - chr9:4685035-4685036(+) m6A CDS//exon       24981863//27773535 chr9:4685049-4685050(+) m6A CDS//exon       24981863//27773535 chr9:4706059-4706060(+) m6A CDS       24284625//24981863//22608085 chr9:4706087-4706088(+) m6A CDS       24284625//24981863//22608085 chr9:4706101-4706102(+) m6A CDS       24284625//24981863//22608085 chr9:4706122-4706123(+) m6A 3'UTR       24284625//24981863//22608085 chr9:4706163-4706164(+) m6A 3'UTR       24284625//24981863//22608085 chr9:4706336-4706337(+) m6A 3'UTR       27773535 chr9:4706341-4706342(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3074-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	CDC37L1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3074-3p
Interactor2: CDC37L1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).