Basic Information:

  VIRBase ID:  

HHID00015586

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3074-3p:  MIMAT0015027          GSKIP:  NM_001271905     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3074-3p	GSKIP
miRBase Accession/Entrez ID	MIMAT0015027	51527
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C14orf129//HSPC210

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3074-3p	rs1239868123 chr9:95086025    G/A rs1359892054 chr9:95086026    G/A rs527734535 chr9:95086037    G/C rs778461843 chr9:95086024    C/T rs1462524363 chr9:95086042    T/TA rs746151874 chr9:95086044    T/A rs746151874 chr9:95086044    T/C rs746151874 chr9:95086044    T/G rs779347857 chr9:95086041    A/G rs959770203 chr9:95086039    T/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GSKIP	chr14:96829823-96829824(+) m1A 5'UTR       26863410 chr14:96829884-96829885(+) m1A 5'UTR//exon       26863196//26863410 chr14:96830369-96830370(+) m6A 5'UTR//intron       25456834 chr14:96830443-96830444(+) m6A 5'UTR//intron       24209618 chr14:96830456-96830457(+) m6A 5'UTR//intron       24209618 chr14:96830759-96830760(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr14:96830765-96830766(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr14:96830778-96830779(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr14:96830899-96830900(+) m6A 5'UTR//intron       24284625//22608085 chr14:96830940-96830941(+) m6A 5'UTR//intron       - chr14:96830996-96830997(+) m6A 5'UTR//intron       24981863 chr14:96831097-96831098(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr14:96831119-96831120(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr14:96831204-96831205(+) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr14:96831311-96831312(+) m6A 5'UTR//intron       22608085 chr14:96831324-96831325(+) m6A 5'UTR//intron       22608085 chr14:96845319-96845320(+) m6A 5'UTR//intron       24981863 chr14:96845346-96845347(+) m6A 5'UTR//intron       24981863 chr14:96848590-96848591(+) m6A CDS       25456834//24981863//22608085 chr14:96848665-96848666(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr14:96848678-96848679(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr14:96848791-96848792(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr14:96848804-96848805(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr14:96848820-96848821(+) m6A CDS       24284625//24209618//24981863//22608085 chr14:96851050-96851051(+) Y intron       25219674 chr14:96851901-96851902(+) m6A CDS       24284625//24209618//24981863//22608085 chr14:96851916-96851917(+) m6A CDS       24284625//24209618//24981863//22608085 chr14:96851987-96851988(+) m6A CDS       24284625//25456834//24981863//26404942//22608085 chr14:96852011-96852012(+) m6A CDS       24284625//25456834//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3074-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	GSKIP	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3074-3p
Interactor2: GSKIP

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).