Detail Information

Basic Information:


  VIRBase ID:  

HHID00015572

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3074-3p:           TMED5:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3074-3p TMED5
miRBase
Accession/Entrez ID		 MIMAT0015027 50999
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CGI-100//p24g2//p28

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-3074-3p
rs1239868123 chr9:95086025    G/A
rs1359892054 chr9:95086026    G/A
rs527734535 chr9:95086037    G/C
rs778461843 chr9:95086024    C/T
rs1462524363 chr9:95086042    T/TA
rs746151874 chr9:95086044    T/A
rs746151874 chr9:95086044    T/C
rs746151874 chr9:95086044    T/G
rs779347857 chr9:95086041    A/G
rs959770203 chr9:95086039    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMED5
chr1:93629017(-) A-I      intronic
chr1:93629418(-) A-I      intronic
chr1:93629026(-) A-I      intronic
chr1:93629069(-) A-I      intronic
chr1:93629034(-) A-I      intronic
chr1:93629432(-) A-I      intronic
chr1:93629066(-) A-I      intronic
chr1:93629487(-) A-I      intronic
chr1:93629439(-) A-I      intronic
chr1:93623063(-) A-I      intronic
chr1:93623228(-) A-I      intronic
chr1:93620720(-) A-I      intronic
chr1:93620674(-) A-I      intronic
chr1:93629477(-) A-I      intronic
chr1:93620781(-) A-I      intronic
chr1:93624273(-) A-I      intronic
chr1:93629039(-) A-I      intronic
chr1:93629040(-) A-I      intronic
chr1:93629100(-) A-I      intronic
chr1:93629501(-) A-I      intronic
chr1:93629271(-) A-I      intronic
chr1:93634158(-) A-I      intronic
chr1:93634316(-) A-I      intronic
chr1:93623151(-) A-I      intronic
chr1:93635437(-) A-I      intronic
chr1:93621251(-) A-I      intronic
chr1:93628956(-) A-I      intronic
chr1:93623510(-) A-I      intronic
chr1:93623052(-) A-I      intronic
chr1:93621307(-) A-I      intronic
chr1:93642283(-) A-I      intronic
chr1:93620516(-) A-I      intronic
chr1:93642952(-) A-I      intronic
chr1:93642967(-) A-I      intronic
chr1:93642169(-) A-I      intronic
chr1:93628550(-) A-I      ncRNA
chr1:93627962(-) A-I      ncRNA
chr1:93628032(-) A-I      ncRNA
chr1:93628071(-) A-I      ncRNA
chr1:93624398(-) A-I      ncRNA
chr1:93628045(-) A-I      ncRNA
chr1:93623634(-) A-I      intronic
chr1:93643052(-) A-I      intronic
chr1:93642891(-) A-I      intronic
chr1:93642242(-) A-I      intronic
chr1:93624302(-) A-I      intronic
chr1:93623514(-) A-I      intronic
chr1:93642377(-) A-I      intronic
chr1:93629457(-) A-I      intronic
chr1:93629276(-) A-I      intronic
chr1:93629316(-) A-I      intronic
chr1:93623492(-) A-I      intronic
chr1:93621321(-) A-I      intronic
chr1:93622163(-) A-I      intronic
chr1:93624318(-) A-I      intronic
chr1:93629268(-) A-I      intronic
chr1:93642987(-) A-I      intronic
chr1:93628543(-) A-I      ncRNA
chr1:93628618(-) A-I      ncRNA
chr1:93628046(-) A-I      ncRNA
chr1:93628097(-) A-I      ncRNA
chr1:93628518(-) A-I      ncRNA
chr1:93628110(-) A-I      ncRNA
chr1:93628514(-) A-I      ncRNA
chr1:93628574(-) A-I      ncRNA
chr1:93628072(-) A-I      ncRNA
chr1:93628623(-) A-I      ncRNA
chr1:93627988(-) A-I      ncRNA
chr1:93624418(-) A-I      ncRNA
chr1:93628042(-) A-I      ncRNA
chr1:93622303(-) A-I      intronic
chr1:93629173(-) A-I      intronic
chr1:93642255(-) A-I      intronic
chr1:93622191(-) A-I      intronic
chr1:93628969(-) A-I      intronic
chr1:93621291(-) A-I      intronic
chr1:93623132(-) A-I      intronic
chr1:93620675(-) A-I      intronic
chr1:93621298(-) A-I      intronic
chr1:93623017(-) A-I      intronic
chr1:93642972(-) A-I      intronic
chr1:93639799(-) A-I      intronic
chr1:93643108(-) A-I      intronic
chr1:93621286(-) A-I      intronic
chr1:93623220(-) A-I      intronic
chr1:93629495(-) A-I      intronic
chr1:93628980(-) A-I      intronic
chr1:93642156(-) A-I      intronic
chr1:93624289(-) A-I      intronic
chr1:93624351(-) A-I      intronic
chr1:93621130(-) A-I      intronic
chr1:93628998(-) A-I      intronic
chr1:93622203(-) A-I      intronic
chr1:93629172(-) A-I      intronic
chr1:93621292(-) A-I      intronic
chr1:93622220(-) A-I      intronic
chr1:93623087(-) A-I      intronic
chr1:93642383(-) A-I      intronic
chr1:93621218(-) A-I      intronic
chr1:93623624(-) A-I      intronic
chr1:93629458(-) A-I      intronic
chr1:93642284(-) A-I      intronic
chr1:93642188(-) A-I      intronic
chr1:93628999(-) A-I      intronic
chr1:93628936(-) A-I      intronic
chr1:93639942(-) A-I      intronic
chr1:93629042(-) A-I      intronic
chr1:93629525(-) A-I      intronic
chr1:93623133(-) A-I      intronic
chr1:93629476(-) A-I      intronic
chr1:93629361(-) A-I      intronic
chr1:93643051(-) A-I      intronic
chr1:93629421(-) A-I      intronic
chr1:93628993(-) A-I      intronic
chr1:93639587(-) A-I      intronic
chr1:93635439(-) A-I      intronic
chr1:93642153(-) A-I      intronic
chr1:93621294(-) A-I      intronic
chr1:93621308(-) A-I      intronic
chr1:93624304(-) A-I      intronic
chr1:93643011(-) A-I      intronic
chr1:93620700(-) A-I      intronic
chr1:93624263(-) A-I      intronic
chr1:93642163(-) A-I      intronic
chr1:93629189(-) A-I      intronic
chr1:93623517(-) A-I      intronic
chr1:93624224(-) A-I      intronic
chr1:93624319(-) A-I      intronic
chr1:93642206(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMED5
chr1:93621294(-) A-I intron -    15258596   //21960545
chr1:93621308(-) A-I intron -    15258596   //16100382   //21960545
chr1:93621321(-) A-I intron -    15258596   //16100382   //21960545
chr1:93627727(-) A-I intron -    15342557
chr1:93627962(-) A-I intron -    15342557   //15258596
chr1:93627988(-) A-I intron -    15342557   //15258596
chr1:93628032(-) A-I intron -    15342557
chr1:93628042(-) A-I intron -    15342557
chr1:93628045(-) A-I intron -    15342557
chr1:93628046(-) A-I intron -    15342557
chr1:93628071(-) A-I intron -    15342557
chr1:93628072(-) A-I intron -    15342557
chr1:93628110(-) A-I intron -    15342557   //15258596
chr1:93628518(-) A-I intron -    15342557   //15258596
chr1:93628543(-) A-I intron -    15342557   //15258596
chr1:93628550(-) A-I intron -    15342557   //15258596
chr1:93628618(-) A-I intron -    15342557
chr1:93628623(-) A-I intron -    15342557
chr1:93621291(-) A-I intron -    21960545
chr1:93620675(-) A-G intron -    22484847
chr1:93621291(-) A-G intron -    22484847
chr1:93621294(-) A-G intron -    22484847
chr1:93621308(-) A-G intron -    22484847
chr1:93621321(-) A-G intron -    22484847
chr1:93622220(-) A-G intron -    22484847
chr1:93622303(-) A-G intron -    22484847
chr1:93623514(-) A-G intron -    22484847
chr1:93623624(-) A-G intron -    22484847
chr1:93623634(-) A-G intron -    22484847
chr1:93624134(-) C-A intron -    22484847
chr1:93624351(-) A-G intron -    22484847
chr1:93628936(-) A-G intron -    22484847
chr1:93628969(-) A-G intron -    22484847
chr1:93628980(-) A-G intron -    22484847
chr1:93628993(-) A-G intron -    22484847
chr1:93628998(-) A-G intron -    22484847
chr1:93629172(-) A-G intron -    22484847
chr1:93629173(-) A-G intron -    22484847
chr1:93629189(-) A-G intron -    22484847
chr1:93629268(-) A-G intron -    22484847
chr1:93629276(-) A-G intron -    22484847
chr1:93629316(-) A-G intron -    22484847
chr1:93629457(-) A-G intron -    22484847
chr1:93629458(-) A-G intron -    22484847
chr1:93629476(-) A-G intron -    22484847
chr1:93629525(-) A-G intron -    22484847
chr1:93635439(-) A-G intron -    22484847
chr1:93642153(-) A-G intron -    22484847
chr1:93642156(-) A-G intron -    22484847
chr1:93642163(-) A-G intron -    22484847
chr1:93642188(-) A-G intron -    22484847
chr1:93642206(-) A-G intron -    22484847
chr1:93642242(-) A-G intron -    22484847
chr1:93642284(-) A-G intron -    22484847
chr1:93642377(-) A-G intron -    22484847
chr1:93642383(-) A-G intron -    22484847
chr1:93642891(-) A-G intron -    22484847
chr1:93642972(-) A-G intron -    22484847
chr1:93643051(-) A-G intron -    22484847
chr1:93643108(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMED5
chr1:93615690-93615691(-) m6A 3'UTR       27773535
chr1:93615718-93615719(-) m6A 3'UTR       27773535
chr1:93615794-93615795(-) m6A 3'UTR       27773535
chr1:93615829-93615830(-) m6A 3'UTR       27773535
chr1:93615862-93615863(-) m6A 3'UTR       27773535
chr1:93617312-93617313(-) m6A 3'UTR       27773535
chr1:93620110-93620111(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr1:93620157-93620158(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22608085
chr1:93620172-93620173(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22608085
chr1:93620217-93620218(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22608085
chr1:93620224-93620225(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22608085
chr1:93620231-93620232(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//28052920//27773535//22608085
chr1:93620359-93620360(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085
chr1:93620393-93620394(-) m6A 3'UTR//CDS//exon       24284625//24981863//22608085
chr1:93620418-93620419(-) m6A 3'UTR//CDS//exon       24284625//24981863//22608085
chr1:93621602-93621603(-) m6A 3'UTR//CDS//intron       24284625//24981863//22608085
chr1:93621639-93621640(-) m6A 3'UTR//CDS//intron       22608085
chr1:93621863-93621864(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr1:93621871-93621872(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr1:93621917-93621918(-) Am 3'UTR//CDS//exon       -
chr1:93621922-93621923(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr1:93621934-93621935(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr1:93622032-93622033(-) m6A 3'UTR//CDS//exon       27773535
chr1:93645740-93645741(-) Y CDS       26075521
chr1:93645845-93645846(-) m6A 5'UTR       24284625//24981863//27773535//27371828//27773536//22608085
chr1:93645900-93645901(-) m6A 5'UTR       24284625//25456834//24981863//27773535//27371828//27773536//22608085
chr1:93645964-93645965(-) m6A 5'UTR       24284625//25456834//24981863//27773535//27371828//27773536//22608085
chr1:93646001-93646002(-) m6A 5'UTR       24284625//25456834//24981863//27773535//27371828//27773536//22608085
chr1:93646023-93646024(-) m6A 5'UTR       25456834//24981863//27371828//22608085
chr1:93646082-93646083(-) m6A 5'UTR       25456834//24981863//27371828//22608085
chr1:93646137-93646138(-) m6A 5'UTR       24209618//24981863//27371828//22575960//22608085
chr1:93646225-93646226(-) m6A 5'UTR       24209618//27371828
chr1:93646282-93646283(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3074-3p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
TMED5
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3074-3p
Interactor2: TMED5

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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