Basic Information:

  VIRBase ID:  

HHID00015550

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3074-3p:  MIMAT0015027          CKAP2:  NM_018204     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3074-3p	CKAP2
miRBase Accession/Entrez ID	MIMAT0015027	26586
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LB1//se20-10//TMAP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3074-3p	rs1239868123 chr9:95086025    G/A rs1359892054 chr9:95086026    G/A rs527734535 chr9:95086037    G/C rs778461843 chr9:95086024    C/T rs1462524363 chr9:95086042    T/TA rs746151874 chr9:95086044    T/A rs746151874 chr9:95086044    T/C rs746151874 chr9:95086044    T/G rs779347857 chr9:95086041    A/G rs959770203 chr9:95086039    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CKAP2	chr13:53032913(+) A-I      intronic chr13:53032811(+) A-I      intronic chr13:53032845(+) A-I      intronic chr13:53034232(+) A-I      intronic chr13:53031128(+) A-I      intronic chr13:53031052(+) A-I      intronic chr13:53040850(+) A-I      intronic chr13:53033597(+) A-I      intronic chr13:53032812(+) A-I      intronic chr13:53032822(+) A-I      intronic chr13:53033600(+) A-I      intronic chr13:53031127(+) A-I      intronic chr13:53031829(+) A-I      intronic chr13:53041678(+) A-I      intronic chr13:53031787(+) A-I      intronic chr13:53034029(+) A-I      intronic chr13:53031830(+) A-I      intronic chr13:53045234(+) A-I      intronic chr13:53045222(+) A-I      intronic chr13:53045214(+) A-I      intronic chr13:53042144(+) A-I      intronic chr13:53041783(+) A-I      intronic chr13:53031177(+) A-I      intronic chr13:53042152(+) A-I      intronic chr13:53041995(+) A-I      intronic chr13:53031835(+) A-I      intronic chr13:53041765(+) A-I      intronic chr13:53034730(+) A-I      intronic chr13:53041733(+) A-I      intronic chr13:53037258(+) A-I      intronic chr13:53034769(+) A-I      intronic chr13:53031839(+) A-I      intronic chr13:53034203(+) A-I      intronic chr13:53041684(+) A-I      intronic chr13:53034107(+) A-I      intronic chr13:53034099(+) A-I      intronic chr13:53032743(+) A-I      intronic chr13:53031846(+) A-I      intronic chr13:53031828(+) A-I      intronic chr13:53032839(+) A-I      intronic chr13:53042086(+) A-I      intronic chr13:53031869(+) A-I      intronic chr13:53032867(+) A-I      intronic chr13:53042075(+) A-I      intronic chr13:53041134(+) A-I      intronic chr13:53031060(+) A-I      intronic chr13:53031086(+) A-I      intronic chr13:53031832(+) A-I      intronic chr13:53032851(+) A-I      intronic chr13:53031215(+) A-I      intronic chr13:53031765(+) A-I      intronic chr13:53031770(+) A-I      intronic chr13:53034654(+) A-I      intronic chr13:53044423(+) A-I      intronic chr13:53031812(+) A-I      intronic chr13:53038510(+) A-I      intronic chr13:53044393(+) A-I      intronic chr13:53031197(+) A-I      intronic chr13:53041622(+) A-I      intronic chr13:53037102(+) A-I      intronic chr13:53041847(+) A-I      intronic chr13:53041656(+) A-I      intronic chr13:53033513(+) A-I      intronic chr13:53041751(+) A-I      intronic chr13:53034089(+) A-I      intronic chr13:53040957(+) A-I      intronic chr13:53040982(+) A-I      intronic chr13:53041682(+) A-I      intronic chr13:53040976(+) A-I      intronic chr13:53042127(+) A-I      intronic chr13:53041140(+) A-I      intronic chr13:53041022(+) A-I      intronic chr13:53041681(+) A-I      intronic chr13:53037142(+) A-I      intronic chr13:53047133(+) A-I      intronic chr13:53038509(+) A-I      intronic chr13:53040852(+) A-I      intronic chr13:53032847(+) A-I      intronic chr13:53041590(+) A-I      intronic chr13:53041621(+) A-I      intronic chr13:53037270(+) A-I      intronic chr13:53041724(+) A-I      intronic chr13:53042130(+) A-I      intronic chr13:53041993(+) A-I      intronic chr13:53045128(+) A-I      intronic chr13:53032894(+) A-I      intronic chr13:53040993(+) A-I      intronic chr13:53032898(+) A-I      intronic chr13:53033587(+) A-I      intronic chr13:53040953(+) A-I      intronic chr13:53044264(+) A-I      intronic chr13:53043993(+) A-I      intronic chr13:53041047(+) A-I      intronic chr13:53034055(+) A-I      intronic chr13:53033726(+) A-I      intronic chr13:53041723(+) A-I      intronic chr13:53037335(+) A-I      intronic chr13:53041786(+) A-I      intronic chr13:53034112(+) A-I      intronic chr13:53034167(+) A-I      intronic chr13:53038432(+) A-I      intronic chr13:53034139(+) A-I      intronic chr13:53034635(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CKAP2	chr13:53037142(+) A-I intron -    22327324 chr13:53037142(+) A-G intron -    22484847 chr13:53037270(+) A-G intron -    22484847 chr13:53040982(+) A-G intron -    22484847 chr13:53041022(+) A-G intron -    22484847 chr13:53041723(+) A-G intron -    22484847 chr13:53041751(+) A-G intron -    22484847 chr13:53041783(+) A-G intron -    22484847 chr13:53045128(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CKAP2	chr13:53029616-53029617(+) m6A 5'UTR       24284625//24981863//22608085 chr13:53029716-53029717(+) m6A 5'UTR//CDS       24284625//24981863 chr13:53030667-53030668(+) m6A 5'UTR//CDS       24981863 chr13:53030673-53030674(+) m6A 5'UTR//CDS       24284625//24981863 chr13:53030682-53030683(+) m6A 5'UTR//CDS       24284625//24981863 chr13:53035062-53035063(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr13:53035079-53035080(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr13:53035093-53035094(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr13:53035100-53035101(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr13:53035205-53035206(+) m6A 5'UTR//CDS       24284625//24981863//27773535//22608085 chr13:53035215-53035216(+) m6A CDS       24284625//24981863//27773535//22608085 chr13:53035251-53035252(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:53035269-53035270(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:53035281-53035282(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:53035317-53035318(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr13:53035336-53035337(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr13:53035412-53035413(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr13:53035428-53035429(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr13:53035446-53035447(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr13:53035476-53035477(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:53035536-53035537(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:53035578-53035579(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:53035608-53035609(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:53035622-53035623(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:53035703-53035704(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:53035754-53035755(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:53035764-53035765(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:53035780-53035781(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:53035824-53035825(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr13:53035840-53035841(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr13:53035861-53035862(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:53035894-53035895(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:53035956-53035957(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr13:53035992-53035993(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:53036044-53036045(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr13:53036584-53036585(+) m6A CDS       24981863//27773535//22608085 chr13:53036596-53036597(+) m6A CDS       24981863//27773535//22608085 chr13:53036615-53036616(+) m6A CDS       24981863//27773535 chr13:53036638-53036639(+) m6A CDS       24981863//27773535 chr13:53036664-53036665(+) m6A CDS       24981863//27773535 chr13:53036688-53036689(+) m6A CDS       24981863 chr13:53048051-53048052(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr13:53048069-53048070(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr13:53048113-53048114(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr13:53048121-53048122(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr13:53048148-53048149(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr13:53048169-53048170(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr13:53049057-53049058(+) m6A CDS//exon       24284625//24981863//22608085 chr13:53049126-53049127(+) m6A CDS//exon       24284625//24981863//22608085 chr13:53049182-53049183(+) m6A CDS//exon       24284625//24981863//22608085 chr13:53049207-53049208(+) m6A CDS//exon       24284625//24981863//22608085 chr13:53049714-53049715(+) Y 3'UTR       25219674

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3074-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	CKAP2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3074-3p
Interactor2: CKAP2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).