Basic Information:

  VIRBase ID:  

HHID00015472

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3074-3p:  MIMAT0015027          B4GALT6:  NM_001378110     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3074-3p	B4GALT6
miRBase Accession/Entrez ID	MIMAT0015027	9331
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	B4Gal-T6//beta4Gal-T6

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3074-3p	rs1239868123 chr9:95086025    G/A rs1359892054 chr9:95086026    G/A rs527734535 chr9:95086037    G/C rs778461843 chr9:95086024    C/T rs1462524363 chr9:95086042    T/TA rs746151874 chr9:95086044    T/A rs746151874 chr9:95086044    T/C rs746151874 chr9:95086044    T/G rs779347857 chr9:95086041    A/G rs959770203 chr9:95086039    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	B4GALT6	chr18:29248720(-) A-I      intronic chr18:29248852(-) A-I      intronic chr18:29223444(-) A-I      intronic chr18:29215779(-) A-I      intronic chr18:29218234(-) A-I      intronic chr18:29250276(-) A-I      intronic chr18:29215729(-) A-I      intronic chr18:29250197(-) A-I      intronic chr18:29247890(-) A-I      intronic chr18:29218484(-) A-I      intronic chr18:29250165(-) A-I      intronic chr18:29218414(-) A-I      intronic chr18:29218378(-) A-I      intronic chr18:29218368(-) A-I      intronic chr18:29218362(-) A-I      intronic chr18:29218317(-) A-I      intronic chr18:29218265(-) A-I      intronic chr18:29239946(-) A-I      intronic chr18:29245642(-) A-I      intronic chr18:29250145(-) A-I      intronic chr18:29250196(-) A-I      intronic chr18:29250195(-) A-I      intronic chr18:29211220(-) A-I      intronic chr18:29247901(-) A-I      intronic chr18:29248911(-) A-I      intronic chr18:29247960(-) A-I      intronic chr18:29248891(-) A-I      intronic chr18:29216988(-) A-I      intronic chr18:29248718(-) A-I      intronic chr18:29216853(-) A-I      intronic chr18:29215737(-) A-I      intronic chr18:29245629(-) A-I      intronic chr18:29247895(-) A-I      intronic chr18:29250171(-) A-I      intronic chr18:29218240(-) A-I      intronic chr18:29218246(-) A-I      intronic chr18:29218323(-) A-I      intronic chr18:29250095(-) A-I      intronic chr18:29245618(-) A-I      intronic chr18:29223541(-) A-I      intronic chr18:29218301(-) A-I      intronic chr18:29216861(-) A-I      intronic chr18:29233666(-) A-I      intronic chr18:29247938(-) A-I      intronic chr18:29216904(-) A-I      intronic chr18:29250191(-) A-I      intronic chr18:29216921(-) A-I      intronic chr18:29211210(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	B4GALT6	chr18:29250191(-) A-G intron -    22484847 chr18:29250195(-) A-G intron -    22484847 chr18:29250196(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	B4GALT6	chr18:29204940-29204941(-) m6A 3'UTR//exon       24981863//22608085 chr18:29205003-29205004(-) m6A 3'UTR//exon       24981863//22608085 chr18:29205029-29205030(-) m6A 3'UTR//exon       24981863//22608085 chr18:29205063-29205064(-) m6A 3'UTR//exon       24981863//22608085 chr18:29205094-29205095(-) m6A 3'UTR//exon       24981863//22608085 chr18:29205117-29205118(-) m6A 3'UTR//exon       22608085 chr18:29205141-29205142(-) m6A 3'UTR//exon       22608085 chr18:29205387-29205388(-) m6A 3'UTR//exon       24284625//24981863//22608085 chr18:29205432-29205433(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr18:29205529-29205530(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr18:29205549-29205550(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27371828//22608085 chr18:29205583-29205584(-) m6A CDS//exon       24284625//24209618//24981863//28052920//22608085 chr18:29205613-29205614(-) m6A CDS//exon       24284625//24209618//24981863//28052920//22608085 chr18:29205625-29205626(-) m6A CDS//exon       24284625//24981863//28052920//22608085 chr18:29205673-29205674(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085 chr18:29205678-29205679(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085 chr18:29206305-29206306(-) m6A CDS//exon       24284625//24981863//22608085 chr18:29206316-29206317(-) m6A CDS//exon       24284625//24981863//22608085 chr18:29264500-29264501(-) m6A 5'UTR//intron       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3074-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	B4GALT6	Cytosol HCC cell line (HepG2)     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3074-3p
Interactor2: B4GALT6

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).