Basic Information:

  VIRBase ID:  

HHID00015457

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3074-3p:  MIMAT0015027          AGPS:  NM_003659     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3074-3p	AGPS
miRBase Accession/Entrez ID	MIMAT0015027	8540
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ADAP-S//ADAS//ADHAPS//ADPS//ALDHPSY//RCDP3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3074-3p	rs1239868123 chr9:95086025    G/A rs1359892054 chr9:95086026    G/A rs527734535 chr9:95086037    G/C rs778461843 chr9:95086024    C/T rs1462524363 chr9:95086042    T/TA rs746151874 chr9:95086044    T/A rs746151874 chr9:95086044    T/C rs746151874 chr9:95086044    T/G rs779347857 chr9:95086041    A/G rs959770203 chr9:95086039    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AGPS	chr2:178339372(+) A-I      intronic chr2:178318024(+) A-I      intronic chr2:178266494(+) A-I      intronic chr2:178391032(+) A-I      intronic chr2:178393933(+) A-I      intronic chr2:178392035(+) A-I      intronic chr2:178392004(+) A-I      intronic chr2:178391980(+) A-I      intronic chr2:178391977(+) A-I      intronic chr2:178391123(+) A-I      intronic chr2:178391037(+) A-I      intronic chr2:178377756(+) A-I      intronic chr2:178377738(+) A-I      intronic chr2:178377737(+) A-I      intronic chr2:178350468(+) A-I      intronic chr2:178350367(+) A-I      intronic chr2:178349765(+) A-I      intronic chr2:178349620(+) A-I      intronic chr2:178349555(+) A-I      intronic chr2:178349554(+) A-I      intronic chr2:178266447(+) A-I      intronic chr2:178335460(+) A-I      intronic chr2:178335455(+) A-I      intronic chr2:178335453(+) A-I      intronic chr2:178329947(+) A-I      intronic chr2:178329942(+) A-I      intronic chr2:178329769(+) A-I      intronic chr2:178328858(+) A-I      intronic chr2:178328811(+) A-I      intronic chr2:178318080(+) A-I      intronic chr2:178394188(+) A-I      intronic chr2:178307393(+) A-I      intronic chr2:178307557(+) A-I      intronic chr2:178391155(+) A-I      intronic chr2:178307454(+) A-I      intronic chr2:178320799(+) A-I      intronic chr2:178307397(+) A-I      intronic chr2:178307383(+) A-I      intronic chr2:178307500(+) A-I      intronic chr2:178328770(+) A-I      intronic chr2:178307428(+) A-I      intronic chr2:178307328(+) A-I      intronic chr2:178307520(+) A-I      intronic chr2:178307388(+) A-I      intronic chr2:178394016(+) A-I      intronic chr2:178307484(+) A-I      intronic chr2:178307527(+) A-I      intronic chr2:178307398(+) A-I      intronic chr2:178307396(+) A-I      intronic chr2:178262494(+) A-I      intronic chr2:178307455(+) A-I      intronic chr2:178307391(+) A-I      intronic chr2:178350570(+) A-I      intronic chr2:178349622(+) A-I      intronic chr2:178307525(+) A-I      intronic chr2:178350416(+) A-I      intronic chr2:178307516(+) A-I      intronic chr2:178320791(+) A-I      intronic chr2:178399607(+) A-I      intronic chr2:178394131(+) A-I      intronic chr2:178307532(+) A-I      intronic chr2:178307524(+) A-I      intronic chr2:178349152(+) A-I      intronic chr2:178391940(+) A-I      intronic chr2:178262488(+) A-I      intronic chr2:178391970(+) A-I      intronic chr2:178350403(+) A-I      intronic chr2:178399604(+) A-I      intronic chr2:178261715(+) A-I      intronic chr2:178328943(+) A-I      intronic chr2:178391138(+) A-I      intronic chr2:178350404(+) A-I      intronic chr2:178394187(+) A-I      intronic chr2:178394132(+) A-I      intronic chr2:178391978(+) A-I      intronic chr2:178375961(+) A-I      intronic chr2:178376009(+) A-I      intronic chr2:178394075(+) A-I      intronic chr2:178349632(+) A-I      intronic chr2:178329771(+) A-I      intronic chr2:178262600(+) A-I      intronic chr2:178350524(+) A-I      intronic chr2:178394095(+) A-I      intronic chr2:178394077(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	AGPS	chr2:178307328(+) A-I intron -    22028664 chr2:178307383(+) A-I intron -    22028664 chr2:178307388(+) A-I intron -    22028664 chr2:178307391(+) A-I intron -    22028664 chr2:178307393(+) A-I intron -    22028664 chr2:178307396(+) A-I intron -    22028664 chr2:178307397(+) A-I intron -    22028664 chr2:178307398(+) A-I intron -    22028664 chr2:178307428(+) A-I intron -    22028664 chr2:178307454(+) A-I intron -    22028664 chr2:178307455(+) A-I intron -    22028664 chr2:178307484(+) A-I intron -    22028664 chr2:178307500(+) A-I intron -    22028664 chr2:178307516(+) A-I intron -    22028664 chr2:178307520(+) A-I intron -    22028664 chr2:178307524(+) A-I intron -    22028664 chr2:178307525(+) A-I intron -    22028664 chr2:178307527(+) A-I intron -    22028664 chr2:178307532(+) A-I intron -    22028664 chr2:178307557(+) A-I intron -    22028664 chr2:178350333(+) A-I intron -    21960545 chr2:178350334(+) A-I intron -    21960545 chr2:178267677(+) C-T intron -    22484847 chr2:178314272(+) T-C intron -    22484847 chr2:178314833(+) A-G intron -    22484847 chr2:178320817(+) A-G intron -    22484847 chr2:178329771(+) A-G intron -    22484847 chr2:178349103(+) A-G intron -    22484847 chr2:178349152(+) A-G intron -    22484847 chr2:178349622(+) A-G intron -    22484847 chr2:178349632(+) A-G intron -    22484847 chr2:178350403(+) A-G intron -    22484847 chr2:178350404(+) A-G intron -    22484847 chr2:178350407(+) A-G intron -    22484847 chr2:178350416(+) A-G intron -    22484847 chr2:178350524(+) A-G intron -    22484847 chr2:178350525(+) A-G intron -    22484847 chr2:178353831(+) G-T intron -    22484847 chr2:178390976(+) G-T intron -    22484847 chr2:178390977(+) A-T intron -    22484847 chr2:178391038(+) A-G intron -    22484847 chr2:178391138(+) A-G intron -    22484847 chr2:178391155(+) A-G intron -    22484847 chr2:178391940(+) A-G intron -    22484847 chr2:178391941(+) A-G intron -    22484847 chr2:178391970(+) A-G intron -    22484847 chr2:178391978(+) A-G intron -    22484847 chr2:178391985(+) A-G intron -    22484847 chr2:178391996(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AGPS	chr2:178257547-178257548(+) m6A CDS       24209618//24981863 chr2:178257587-178257588(+) m6A CDS       24209618//24981863//22575960 chr2:178257593-178257594(+) m6A CDS       24209618//24981863//22575960 chr2:178257599-178257600(+) m6A CDS       24209618//24981863//22575960 chr2:178257605-178257606(+) m6A CDS       24209618//24981863//22575960 chr2:178257611-178257612(+) m6A CDS       24209618//24981863//22575960 chr2:178299133-178299134(+) m6A CDS//intron       27773535 chr2:178310335-178310336(+) m6A CDS//intron       27773535 chr2:178310350-178310351(+) m6A CDS//intron       24981863//27773535//22575960 chr2:178326652-178326653(+) m6A CDS//intron       24981863//27773535//22575960 chr2:178326741-178326742(+) m6A CDS//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3074-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	AGPS	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3074-3p
Interactor2: AGPS

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).