Basic Information:

  VIRBase ID:  

HHID00015357

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3074-3p:  MIMAT0015027          GLRX:  NM_001243659     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3074-3p	GLRX
miRBase Accession/Entrez ID	MIMAT0015027	2745
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GRX//GRX1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3074-3p	rs1239868123 chr9:95086025    G/A rs1359892054 chr9:95086026    G/A rs527734535 chr9:95086037    G/C rs778461843 chr9:95086024    C/T rs1462524363 chr9:95086042    T/TA rs746151874 chr9:95086044    T/A rs746151874 chr9:95086044    T/C rs746151874 chr9:95086044    T/G rs779347857 chr9:95086041    A/G rs959770203 chr9:95086039    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GLRX	chr5:95135488(-) A-I      intronic chr5:95141825(-) A-I      intronic chr5:95118331(-) A-I      ncRNA chr5:95118510(-) A-I      ncRNA chr5:95118382(-) A-I      ncRNA chr5:95118323(-) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GLRX	chr5:95153063(-) T-C intron -    22484847 chr5:95156285(-) A-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GLRX	chr5:95149797-95149798(-) m6A 3'UTR//exon//intron       24284625//28052920 chr5:95149853-95149854(-) m6A 3'UTR//exon//intron       24981863 chr5:95149865-95149866(-) m6A 3'UTR//exon//intron       24981863 chr5:95149898-95149899(-) m6A 3'UTR//exon//intron       24981863 chr5:95149922-95149923(-) m6A 3'UTR//exon//intron       24981863 chr5:95149961-95149962(-) m6A 3'UTR//exon//intron       24981863 chr5:95154402-95154403(-) m6A exon//intron       27773535 chr5:95154516-95154517(-) m6A exon//intron       27773535 chr5:95158249-95158250(-) m6A CDS       24284625//27371828//22608085 chr5:95158346-95158347(-) m6A CDS       24284625//24981863//27371828//22608085 chr5:95158381-95158382(-) m6A 5'UTR       24284625//25456834//24981863//27371828//22608085 chr5:95158483-95158484(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3074-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
	GLRX	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3074-3p
Interactor2: GLRX

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).