Detail Information

Basic Information:


  VIRBase ID:  

HHID00015312

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:           PPP4R1L:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365a-5p PPP4R1L
miRBase
Accession/Entrez ID		 MIMAT0009199 55370
Organism Homo sapiens Homo sapiens
Category miRNA pseudo
Alias - C20orf192//PPP4R1P1//PRO1085

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365a-5p
rs1166908611 chr16:14309308    T/C
rs1368596991 chr16:14309314    G/A
rs1380926089 chr16:14309318    A/G
rs1396179427 chr16:14309310    G/C
rs1428928383 chr16:14309320    G/A
rs773834113 chr16:14309301    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PPP4R1L
chr20:56875330(-) A-I      intronic
chr20:56875318(-) A-I      intronic
chr20:56875308(-) A-I      intronic
chr20:56882849(-) A-I      intronic
chr20:56882850(-) A-I      intronic
chr20:56882859(-) A-I      intronic
chr20:56851388(-) A-I      intronic
chr20:56854559(-) A-I      intronic
chr20:56854663(-) A-I      intronic
chr20:56859522(-) A-I      intronic
chr20:56859523(-) A-I      intronic
chr20:56867960(-) A-I      intronic
chr20:56875266(-) A-I      intronic
chr20:56875269(-) A-I      intronic
chr20:56882700(-) A-I      intronic
chr20:56882752(-) A-I      intronic
chr20:56854668(-) A-I      intronic
chr20:56883012(-) A-I      intronic
chr20:56854678(-) A-I      intronic
chr20:56854597(-) A-I      intronic
chr20:56883181(-) A-I      intronic
chr20:56859419(-) A-I      intronic
chr20:56859543(-) A-I      intronic
chr20:56882915(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PPP4R1L
chr20:56804139-56804140(-) m6A exon       -
chr20:56806655-56806656(-) m6A exon       24981863
chr20:56806660-56806661(-) m6A exon       24981863
chr20:56806716-56806717(-) m6A exon       24284625//24981863//22608085
chr20:56806752-56806753(-) m6A exon       24284625//24209618//24981863//27371828//22608085
chr20:56806834-56806835(-) m6A exon       24284625//24981863//27371828//22608085
chr20:56806853-56806854(-) m6A exon       24284625//24981863//27371828//22608085
chr20:56806876-56806877(-) m6A exon       24981863//22608085
chr20:56806907-56806908(-) m6A exon       22608085
chr20:56806913-56806914(-) m6A exon       22608085
chr20:56806935-56806936(-) m6A exon       -
chr20:56820935-56820936(-) m6A exon       24284625//25456834//24981863//22608085
chr20:56820987-56820988(-) m6A exon       24284625//25456834//24981863//27371828//22608085
chr20:56821012-56821013(-) m6A exon       24284625//25456834//24981863//27371828//22608085
chr20:56821050-56821051(-) m6A exon       24284625//24981863//27371828//22608085
chr20:56821135-56821136(-) m6A exon       24284625//27371828//22608085
chr20:56821153-56821154(-) m6A exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365a-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
PPP4R1L
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug PPP4R1L
Panobinostat       6918837
3-Hydroxy-3'-nitro-2-naphthanilide       67277
Nilotinib       644241
Irinotecan       60838
Topotecan       60700
3-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol;hydrochloride       57399804
l-685,458       5479543
Zimeldine       5365247
Palbociclib       5330286
Alsterpaullone       5005498
Ribavirin       37542
Methyl 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxylate       25263110
Nutlin-3       216345
Adiantifoline       167937
2'-Deoxyuridine       13712
Dovitinib       135398510
Crizotinib       11626560
7-benzyl-5,7-dihydro-4h-isoxazolo[5,4-e]isoindole       -
;(E)-3-(3-((1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)met...       -
;(E)-3-(4-methoxy-3-((1-(4-methoxybenzyl)-1H-1,2,3-triaz...       -
ellipticine, 6-(3-aminopropyl)-, dihydrochloride       -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365a-5p
Interactor2: PPP4R1L

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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