Detail Information

Basic Information:


  VIRBase ID:  

HHID00015301

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365a-5p CTD-2140B24.4
miRBase
Accession/Entrez ID		 MIMAT0009199 CTD-2140B24.4
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365a-5p
rs1166908611 chr16:14309308    T/C
rs1368596991 chr16:14309314    G/A
rs1380926089 chr16:14309318    A/G
rs1396179427 chr16:14309310    G/C
rs1428928383 chr16:14309320    G/A
rs773834113 chr16:14309301    G/C

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CTD-2140B24.4
chr12:133728480-133728481(+) m6A CDS       24981863
chr12:133732096-133732097(+) m6A CDS       24981863
chr12:133732232-133732233(+) m6A CDS       24284625//25456834//24981863//27773535//22608085
chr12:133732241-133732242(+) m6A CDS       24284625//25456834//24981863//27773535//22608085
chr12:133732256-133732257(+) m6A CDS       24284625//25456834//24981863//27773535//22608085
chr12:133732266-133732267(+) m6A CDS       24284625//25456834//24981863//27773535//22608085
chr12:133732346-133732347(+) m6A intron       24981863//22608085
chr12:133732419-133732420(+) m6A intron       24981863//22608085
chr12:133732448-133732449(+) m6A intron       24981863//22608085
chr12:133732483-133732484(+) m6A intron       24981863//22608085
chr12:133732496-133732497(+) m6A intron       24981863//22608085
chr12:133732522-133732523(+) m6A intron       24981863//22608085
chr12:133732620-133732621(+) m6A intron       22608085
chr12:133732704-133732705(+) m6A intron       24284625//22608085
chr12:133732761-133732762(+) m6A intron       24284625//24209618//24981863//22608085
chr12:133732771-133732772(+) m6A intron       24284625//24209618//24981863//22608085
chr12:133732788-133732789(+) m6A intron       24284625//24209618//24981863//27773535//22608085
chr12:133732855-133732856(+) m6A intron       24284625//24209618//24981863//27773535//22608085
chr12:133732868-133732869(+) m6A intron       24284625//24209618//24981863//27773535//22608085
chr12:133732929-133732930(+) m6A intron       24284625//24981863//27773535//22608085
chr12:133732939-133732940(+) m6A intron       24284625//24981863//27773535//22608085
chr12:133732956-133732957(+) m6A intron       24284625//24981863//27773535//22608085
chr12:133732992-133732993(+) m6A intron       24284625//24981863//27773535//22608085
chr12:133733023-133733024(+) m6A intron       24284625//24981863//22608085
chr12:133733118-133733119(+) m6A intron       24284625//24981863//22608085
chr12:133733124-133733125(+) m6A intron       24284625//24981863//22608085
chr12:133733191-133733192(+) m6A intron       24284625//24981863//22608085
chr12:133733208-133733209(+) m6A intron       24981863//22608085
chr12:133733292-133733293(+) m6A intron       24981863//22608085
chr12:133733377-133733378(+) m6A intron       24284625//24981863//27773535//22608085
chr12:133733417-133733418(+) m6A intron       24284625//24981863//27773535//22608085
chr12:133733485-133733486(+) m6A intron       24284625//24981863//27773535//22608085
chr12:133733524-133733525(+) m6A intron       24981863//27773535//22608085
chr12:133733605-133733606(+) m6A intron       24981863//22608085
chr12:133733707-133733708(+) m6A intron       22608085
chr12:133758189-133758190(+) m6A intron       24981863
chr12:133778780-133778781(+) m6A 3'UTR       24981863
chr12:133778829-133778830(+) m6A 3'UTR       24981863//22608085
chr12:133778862-133778863(+) m6A 3'UTR       24981863//22608085
chr12:133778868-133778869(+) m6A 3'UTR       24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365a-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365a-5p
Interactor2: CTD-2140B24.4

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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