Detail Information

Basic Information:


  VIRBase ID:  

HHID00015295

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365a-5p AL357673.1
miRBase
Accession/Entrez ID		 MIMAT0009199 AL357673.1
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365a-5p
rs1166908611 chr16:14309308    T/C
rs1368596991 chr16:14309314    G/A
rs1380926089 chr16:14309318    A/G
rs1396179427 chr16:14309310    G/C
rs1428928383 chr16:14309320    G/A
rs773834113 chr16:14309301    G/C

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase AL357673.1
chr1:54635425-54635426(-) m6A 3'UTR       27773535
chr1:54635441-54635442(-) m6A 3'UTR       27773535
chr1:54635560-54635561(-) m6A 3'UTR       24981863//27773535
chr1:54635566-54635567(-) m6A 3'UTR       24981863//27773535
chr1:54635597-54635598(-) m6A 3'UTR       24981863//27773535//22608085
chr1:54635606-54635607(-) m6A 3'UTR       24981863//27773535//22608085
chr1:54635671-54635672(-) m6A 3'UTR       27773535//22608085
chr1:54635710-54635711(-) m6A 3'UTR       27773535
chr1:54636938-54636939(-) m6A CDS       27773535
chr1:54636985-54636986(-) m6A CDS       24284625//27773535
chr1:54637094-54637095(-) m6A CDS       27773535
chr1:54637099-54637100(-) m6A CDS       27773535
chr1:54637224-54637225(-) m6A 5'UTR       27773535
chr1:54637559-54637560(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365a-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365a-5p
Interactor2: AL357673.1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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