Basic Information:

  VIRBase ID:  

HHID00015253

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          SMIM15:  NM_001048249     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	SMIM15
miRBase Accession/Entrez ID	MIMAT0009199	643155
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C5orf43

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SMIM15	chr5:60454459-60454460(-) m6A 3'UTR       27773535 chr5:60454464-60454465(-) m6A 3'UTR       27773535 chr5:60454606-60454607(-) m6A 3'UTR       27773535 chr5:60454627-60454628(-) m6A 3'UTR       27773535 chr5:60454739-60454740(-) m6A 3'UTR       24981863 chr5:60455259-60455260(-) m6A 3'UTR       27773535 chr5:60455367-60455368(-) m6A 3'UTR       24209618//24981863//27773535//22608085 chr5:60455397-60455398(-) m6A 3'UTR       24209618//24981863//27773535//22608085 chr5:60455426-60455427(-) m6A 3'UTR       24209618//24981863//27773535//22608085 chr5:60455441-60455442(-) m6A 3'UTR       24209618//24981863//27773535//22608085 chr5:60455475-60455476(-) m6A 3'UTR       24209618//24981863//27773535//22608085 chr5:60455764-60455765(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr5:60455769-60455770(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr5:60455807-60455808(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr5:60455945-60455946(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr5:60456009-60456010(-) m6A 5'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr5:60456945-60456946(-) m6A 5'UTR       24284625//24209618//24981863//28052920//27773535//22608085 chr5:60456998-60456999(-) m6A 5'UTR       24284625//24209618//24981863//27773535//22608085 chr5:60457008-60457009(-) m6A 5'UTR       24284625//24209618//24981863//27773535//22608085 chr5:60457034-60457035(-) m6A 5'UTR       24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	SMIM15	Exosome Blood     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: SMIM15

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).