Basic Information:

  VIRBase ID:  

HHID00015216

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          ZNF773:  NM_198542     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	ZNF773
miRBase Accession/Entrez ID	MIMAT0009199	374928
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ZNF419B

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF773	chr19:58019141(+) A-I      3'UTR chr19:58019142(+) A-I      3'UTR chr19:58019195(+) A-I      3'UTR chr19:58019160(+) A-I      3'UTR chr19:58019163(+) A-I      3'UTR chr19:58019165(+) A-I      3'UTR chr19:58019202(+) A-I      3'UTR chr19:58019296(+) A-I      3'UTR chr19:58019220(+) A-I      3'UTR chr19:58017217(+) A-I      intronic chr19:58019120(+) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF773	chr19:58017843-58017844(+) m6A CDS//intron       - chr19:58018095-58018096(+) m6A CDS//intron       24981863 chr19:58018901-58018902(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr19:58018917-58018918(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr19:58018933-58018934(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr19:58019001-58019002(+) m6A 3'UTR//intron       25456834//24981863//27773535//22608085 chr19:58019019-58019020(+) m6A 3'UTR//intron       24209618//25456834//24981863//27773535//22608085 chr19:58019057-58019058(+) m6A 3'UTR//intron       24209618//25456834//24981863//27773535//22608085 chr19:58019133-58019134(+) m6A 3'UTR//intron       25456834//24981863//22608085 chr19:58019141-58019142(+) m6A 3'UTR//intron       25456834//24981863//22608085 chr19:58019164-58019165(+) m6A 3'UTR//intron       25456834//24981863//22608085 chr19:58019261-58019262(+) m6A 3'UTR//intron       24981863//22608085 chr19:58019312-58019313(+) m6A 3'UTR//intron       24981863//22608085 chr19:58019330-58019331(+) m6A 3'UTR//intron       24981863//22608085 chr19:58019429-58019430(+) m6A 3'UTR//intron       25456834//22608085 chr19:58019498-58019499(+) m6A 3'UTR//intron       25456834//22608085 chr19:58019525-58019526(+) m6A 3'UTR//intron       22608085 chr19:58024395-58024396(+) m6A CDS       22608085 chr19:58027476-58027477(+) m6A 3'UTR       - chr19:58027556-58027557(+) m6A 3'UTR       25456834//24981863 chr19:58027561-58027562(+) m6A 3'UTR       25456834//24981863 chr19:58027567-58027568(+) m6A 3'UTR       25456834//24981863 chr19:58027609-58027610(+) m6A 3'UTR       25456834//24981863 chr19:58027622-58027623(+) m6A 3'UTR       25456834//24981863 chr19:58027642-58027643(+) m6A 3'UTR       25456834//24981863 chr19:58027656-58027657(+) m6A 3'UTR       25456834//24981863 chr19:58027731-58027732(+) m6A 3'UTR       - chr19:58028953-58028954(+) m6A 3'UTR       24981863 chr19:58028974-58028975(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	ZNF773	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: ZNF773

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).