Basic Information:

  VIRBase ID:  

HHID00015215

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          EFCAB5:  NM_198529     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	EFCAB5
miRBase Accession/Entrez ID	MIMAT0009199	374786
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EFCAB5	chr17:28433544(+) A-I      intronic chr17:28397694(+) A-I      intronic chr17:28433514(+) A-I      intronic chr17:28396072(+) A-I      intronic chr17:28396078(+) A-I      intronic chr17:28396102(+) A-I      intronic chr17:28396119(+) A-I      intronic chr17:28396121(+) A-I      intronic chr17:28396123(+) A-I      intronic chr17:28397718(+) A-I      intronic chr17:28397690(+) A-I      intronic chr17:28271850(+) A-I      intronic chr17:28271822(+) A-I      intronic chr17:28433536(+) A-I      intronic chr17:28433538(+) A-I      intronic chr17:28271869(+) A-I      intronic chr17:28333731(+) A-I      intronic chr17:28273699(+) A-I      intronic chr17:28273983(+) A-I      intronic chr17:28302334(+) A-I      intronic chr17:28267979(+) A-I      intronic chr17:28427745(+) A-I      intronic chr17:28302378(+) A-I      intronic chr17:28333704(+) A-I      intronic chr17:28267992(+) A-I      intronic chr17:28267999(+) A-I      intronic chr17:28427760(+) A-I      intronic chr17:28271861(+) A-I      intronic chr17:28333732(+) A-I      intronic chr17:28427735(+) A-I      intronic chr17:28427742(+) A-I      intronic chr17:28400850(+) A-I      3'UTR chr17:28421701(+) A-I      intronic chr17:28306221(+) A-I      intronic chr17:28271163(+) A-I      intronic chr17:28262395(+) A-I      intronic chr17:28273611(+) A-I      intronic chr17:28320898(+) A-I      intronic chr17:28273584(+) A-I      intronic chr17:28262322(+) A-I      intronic chr17:28273986(+) A-I      intronic chr17:28273992(+) A-I      intronic chr17:28412693(+) A-I      intronic chr17:28270942(+) A-I      intronic chr17:28262398(+) A-I      intronic chr17:28397853(+) A-I      intronic chr17:28273638(+) A-I      intronic chr17:28401338(+) A-I      3'UTR chr17:28388821(+) A-I      intronic chr17:28274071(+) A-I      intronic chr17:28271333(+) A-I      intronic chr17:28272475(+) A-I      intronic chr17:28388637(+) A-I      intronic chr17:28271206(+) A-I      intronic chr17:28271299(+) A-I      intronic chr17:28274042(+) A-I      intronic chr17:28275010(+) A-I      intronic chr17:28400838(+) A-I      3'UTR chr17:28419669(+) A-I      intronic chr17:28272520(+) A-I      intronic chr17:28270899(+) A-I      intronic chr17:28320882(+) A-I      intronic chr17:28361475(+) A-I      intronic chr17:28432329(+) A-I      intronic chr17:28301028(+) A-I      intronic chr17:28271144(+) A-I      intronic chr17:28272552(+) A-I      intronic chr17:28273978(+) A-I      intronic chr17:28271143(+) A-I      intronic chr17:28386302(+) A-I      intronic chr17:28413148(+) A-I      intronic chr17:28270882(+) A-I      intronic chr17:28433506(+) A-I      intronic chr17:28273985(+) A-I      intronic chr17:28272480(+) A-I      intronic chr17:28397713(+) A-I      intronic chr17:28271155(+) A-I      intronic chr17:28320879(+) A-I      intronic chr17:28413114(+) A-I      intronic chr17:28396077(+) A-I      intronic chr17:28397847(+) A-I      intronic chr17:28413031(+) A-I      intronic chr17:28273964(+) A-I      intronic chr17:28344089(+) A-I      intronic chr17:28433495(+) A-I      intronic chr17:28430874(+) A-I      intronic chr17:28262321(+) A-I      intronic chr17:28430040(+) A-I      intronic chr17:28413746(+) A-I      intronic chr17:28413787(+) A-I      intronic chr17:28270873(+) A-I      intronic chr17:28397712(+) A-I      intronic chr17:28433601(+) A-I      intronic chr17:28273641(+) A-I      intronic chr17:28424989(+) A-I      intronic chr17:28274196(+) A-I      intronic chr17:28274045(+) A-I      intronic chr17:28275018(+) A-I      intronic chr17:28432346(+) A-I      intronic chr17:28413147(+) A-I      intronic chr17:28271351(+) A-I      intronic chr17:28401343(+) A-I      3'UTR chr17:28400854(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EFCAB5	chr17:28396077(+) A-I intron -    22327324 chr17:28386302(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EFCAB5	chr17:28256949-28256950(+) m6A 5'UTR//exon//intron       - chr17:28269273-28269274(+) m6A 5'UTR//CDS//exon       - chr17:28269291-28269292(+) m6A 5'UTR//CDS//exon       - chr17:28295927-28295928(+) m6A CDS//intron       - chr17:28295932-28295933(+) m6A CDS//intron       - chr17:28295967-28295968(+) m6A CDS//intron       - chr17:28296043-28296044(+) m6A CDS//intron       - chr17:28296067-28296068(+) m6A CDS//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	EFCAB5	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: EFCAB5

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).