Basic Information:

  VIRBase ID:  

HHID00015157

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          SCUBE3:  NM_152753     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	SCUBE3
miRBase Accession/Entrez ID	MIMAT0009199	222663
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CEGF3//SSFSC2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SCUBE3	chr6:35190696(+) A-I      intronic chr6:35219067(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SCUBE3	chr6:35190929(+) A-I intron -    22327324 chr6:35190929(+) T-C intron -    22484847 chr6:35192170(+) T-C intron -    22484847 chr6:35192239(+) T-C intron -    22484847 chr6:35192242(+) T-C intron -    22484847 chr6:35192245(+) T-C intron -    22484847 chr6:35192283(+) T-C intron -    22484847 chr6:35194336(+) T-C intron -    22484847 chr6:35197130(+) T-C intron -    22484847 chr6:35197131(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SCUBE3	chr6:35216403-35216404(+) m6A CDS       24981863 chr6:35216499-35216500(+) m6A 3'UTR       24981863 chr6:35216521-35216522(+) m6A 3'UTR       24981863 chr6:35216560-35216561(+) m6A 3'UTR       24981863 chr6:35216567-35216568(+) m6A 3'UTR       24981863 chr6:35216614-35216615(+) m6A 3'UTR       24981863 chr6:35217154-35217155(+) m6A 3'UTR       24981863 chr6:35217226-35217227(+) m6A 3'UTR       24981863 chr6:35217242-35217243(+) m6A 3'UTR       24981863 chr6:35217248-35217249(+) m6A 3'UTR       24981863 chr6:35217281-35217282(+) m6A 3'UTR       24981863 chr6:35217310-35217311(+) m6A 3'UTR       24981863 chr6:35217315-35217316(+) m6A 3'UTR       24981863 chr6:35217322-35217323(+) m6A 3'UTR       24981863 chr6:35217343-35217344(+) m6A 3'UTR       24981863 chr6:35217822-35217823(+) m6A 3'UTR       27773535 chr6:35217969-35217970(+) m6A 3'UTR       24981863 chr6:35217984-35217985(+) m6A 3'UTR       24981863 chr6:35218027-35218028(+) m6A 3'UTR       24981863 chr6:35218053-35218054(+) m6A 3'UTR       24981863 chr6:35218087-35218088(+) m6A 3'UTR       24981863 chr6:35218144-35218145(+) m6A 3'UTR       24981863 chr6:35218150-35218151(+) m6A 3'UTR       24981863 chr6:35218195-35218196(+) m6A 3'UTR       24981863 chr6:35218221-35218222(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	SCUBE3	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: SCUBE3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).