Detail Information

Basic Information:


  VIRBase ID:  

HHID00015155

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:           TMED4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365a-5p TMED4
miRBase
Accession/Entrez ID		 MIMAT0009199 222068
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ERS25//GMP25iso//HNLF//p24a3//p24alpha3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365a-5p
rs1166908611 chr16:14309308    T/C
rs1368596991 chr16:14309314    G/A
rs1380926089 chr16:14309318    A/G
rs1396179427 chr16:14309310    G/C
rs1428928383 chr16:14309320    G/A
rs773834113 chr16:14309301    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMED4
chr7:44618327(-) A-I      3'UTR
chr7:44618330(-) A-I      3'UTR
chr7:44618341(-) A-I      3'UTR
chr7:44618356(-) A-I      3'UTR
chr7:44618365(-) A-I      3'UTR
chr7:44618440(-) A-I      3'UTR
chr7:44618459(-) A-I      3'UTR
chr7:44618248(-) A-I      3'UTR
chr7:44618321(-) A-I      3'UTR
chr7:44618285(-) A-I      3'UTR
chr7:44618317(-) A-I      3'UTR
chr7:44618343(-) A-I      3'UTR
chr7:44618427(-) A-I      3'UTR
chr7:44618381(-) A-I      3'UTR
chr7:44618299(-) A-I      3'UTR
chr7:44618230(-) A-I      3'UTR
chr7:44618282(-) A-I      3'UTR
chr7:44618353(-) A-I      3'UTR
chr7:44618308(-) A-I      3'UTR
chr7:44618382(-) A-I      3'UTR
chr7:44618378(-) A-I      3'UTR
chr7:44618262(-) A-I      3'UTR
chr7:44618273(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMED4
chr7:44620289(-) A-I intron -    21960545
chr7:44619821(-) A-G intron -    22484847
chr7:44619833(-) A-G intron -    22484847
chr7:44619843(-) A-G intron -    22484847
chr7:44619885(-) A-G intron -    22484847
chr7:44619897(-) A-G intron -    22484847
chr7:44619911(-) A-G intron -    22484847
chr7:44620001(-) A-G intron -    22484847
chr7:44620289(-) A-G intron -    22484847
chr7:44620301(-) A-G intron -    22484847
chr7:44620302(-) A-G intron -    22484847
chr7:44620311(-) A-G intron -    22484847
chr7:44620381(-) A-G intron -    22484847
chr7:44620424(-) A-G intron -    22484847
chr7:44620470(-) A-G intron -    22484847
chr7:44620500(-) A-G intron -    22484847
chr7:44620508(-) A-G intron -    22484847
chr7:44620546(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMED4
chr7:44617497-44617498(-) m6A 3'UTR       27773535
chr7:44617590-44617591(-) m6A 3'UTR       27773535
chr7:44617630-44617631(-) m6A 3'UTR       27773535
chr7:44617699-44617700(-) m6A 3'UTR       22575960
chr7:44617769-44617770(-) m6A 3'UTR       25456834//24981863//22575960
chr7:44617795-44617796(-) m6A 3'UTR       25456834//24981863//22575960
chr7:44617807-44617808(-) m6A 3'UTR       25456834//24981863//22575960
chr7:44618259-44618260(-) m6A 3'UTR       24209618
chr7:44619154-44619155(-) m6A CDS       27371828
chr7:44619509-44619510(-) m6A 3'UTR//exon//intron       27371828
chr7:44620108-44620109(-) m6A 3'UTR//exon//intron       27773535
chr7:44620126-44620127(-) m6A 3'UTR//exon//intron       27773535
chr7:44621334-44621335(-) m6A CDS//exon       27773535
chr7:44621657-44621658(-) m6A CDS//exon       24981863//27371828//27773536
chr7:44621696-44621697(-) m6A CDS//exon       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365a-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
TMED4
Cytosol HeLa-S3 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365a-5p
Interactor2: TMED4

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

Starting a new search, please wait ...