Basic Information:

  VIRBase ID:  

HHID00015150

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          LRTOMT:  NM_001145308     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	LRTOMT
miRBase Accession/Entrez ID	MIMAT0009199	220074
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CFAP111//DFNB63//LRRC51

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LRTOMT	chr11:71795808(+) A-I      intronic chr11:71792301(+) A-I      intronic chr11:71792307(+) A-I      intronic chr11:71792279(+) A-I      intronic chr11:71817974(+) A-I      intronic chr11:71807006(+) A-I      3'UTR chr11:71792257(+) A-I      intronic chr11:71794680(+) A-I      intronic chr11:71795692(+) A-I      intronic chr11:71795784(+) A-I      intronic chr11:71795803(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LRTOMT	chr11:71791595-71791596(+) m6A 5'UTR       24981863 chr11:71791717-71791718(+) m6A 5'UTR       24981863 chr11:71791746-71791747(+) m6A 5'UTR       24981863 chr11:71791795-71791796(+) m6A 5'UTR       24981863 chr11:71791909-71791910(+) m6A 5'UTR//exon//intron       24981863 chr11:71794832-71794833(+) m6A 5'UTR//intron       24981863 chr11:71794848-71794849(+) m6A 5'UTR//intron       24981863 chr11:71794887-71794888(+) m6A 5'UTR//intron       24981863 chr11:71799366-71799367(+) m6A 5'UTR//intron       - chr11:71820664-71820665(+) m6A 3'UTR       27371828//27773536 chr11:71820670-71820671(+) m6A 3'UTR       27371828//27773536 chr11:71820675-71820676(+) m6A 3'UTR       27371828//27773536 chr11:71820749-71820750(+) m6A 3'UTR       27371828//27773536 chr11:71820776-71820777(+) m6A 3'UTR       27371828//27773536 chr11:71821102-71821103(+) m6A 3'UTR       24209618//24981863//27773535//27371828//22608085 chr11:71821283-71821284(+) m6A 3'UTR       24209618//24981863//27773535//27371828//22575960 chr11:71821315-71821316(+) m6A 3'UTR       24209618//24981863//27773535//27371828 chr11:71821327-71821328(+) m6A 3'UTR       24209618//24981863//27773535//27371828 chr11:71821512-71821513(+) m6A 3'UTR       24209618//24981863 chr11:71821517-71821518(+) m6A 3'UTR       24209618//24981863 chr11:71821614-71821615(+) m6A 3'UTR       24209618 chr11:71821671-71821672(+) m6A 3'UTR       24209618

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	LRTOMT	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: LRTOMT

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).