Detail Information

Basic Information:


  VIRBase ID:  

HHID00015131

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:           PPP1R18:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365a-5p PPP1R18
miRBase
Accession/Entrez ID		 MIMAT0009199 170954
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HKMT1098//KIAA1949

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365a-5p
rs1166908611 chr16:14309308    T/C
rs1368596991 chr16:14309314    G/A
rs1380926089 chr16:14309318    A/G
rs1396179427 chr16:14309310    G/C
rs1428928383 chr16:14309320    G/A
rs773834113 chr16:14309301    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PPP1R18
chr6:30645844(-) A-I      intronic
chr6:30645920(-) A-I      intronic
chr6:30645561(-) A-I      intronic
chr6:30645548(-) A-I      intronic
chr6:30645915(-) A-I      intronic
chr6:30645406(-) A-I      intronic
chr6:30645547(-) A-I      intronic
chr6:30645432(-) A-I      intronic
chr6:30645753(-) A-I      intronic
chr6:30645586(-) A-I      intronic
chr6:30645580(-) A-I      intronic
chr6:30645578(-) A-I      intronic
chr6:30645476(-) A-I      intronic
chr6:30645467(-) A-I      intronic
chr6:30645870(-) A-I      intronic
chr6:30645867(-) A-I      intronic
chr6:30645452(-) A-I      intronic
chr6:30645776(-) A-I      intronic
chr6:30645567(-) A-I      intronic
chr6:30645921(-) A-I      intronic
chr6:30645441(-) A-I      intronic
chr6:30645577(-) A-I      intronic
chr6:30645489(-) A-I      intronic
chr6:30646497(-) A-I      intronic
chr6:30645419(-) A-I      intronic
chr6:30645790(-) A-I      intronic
chr6:30646557(-) A-I      intronic
chr6:30645622(-) A-I      intronic
chr6:30645389(-) A-I      intronic
chr6:30645524(-) A-I      intronic
chr6:30645458(-) A-I      intronic
chr6:30645912(-) A-I      intronic
chr6:30645793(-) A-I      intronic
chr6:30645461(-) A-I      intronic
chr6:30645512(-) A-I      intronic
chr6:30645866(-) A-I      intronic
chr6:30645742(-) A-I      intronic
chr6:30645381(-) A-I      intronic
chr6:30646017(-) A-I      intronic
chr6:30646291(-) A-I      intronic
chr6:30645484(-) A-I      intronic
chr6:30645887(-) A-I      intronic
chr6:30645785(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PPP1R18
chr6:30644646-30644647(-) m6A 3'UTR//exon       24284625//27773535
chr6:30644686-30644687(-) m6A 3'UTR//exon       24284625//27773535
chr6:30644969-30644970(-) m6A 3'UTR//exon       24284625//27773535
chr6:30647132-30647133(-) m6A CDS//exon       24284625//27773535
chr6:30647144-30647145(-) m6A CDS//exon       24284625//27773535
chr6:30652187-30652188(-) m6A CDS//exon//intron       24284625//27773535
chr6:30652196-30652197(-) m6A CDS//exon//intron       24284625//27773535
chr6:30652388-30652389(-) m6A CDS//intron       24284625//27371828//27773536
chr6:30652553-30652554(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30652567-30652568(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30652611-30652612(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30652724-30652725(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30652730-30652731(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30652738-30652739(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30652752-30652753(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30652762-30652763(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30652785-30652786(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30652792-30652793(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30652903-30652904(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30652921-30652922(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30652983-30652984(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:30652988-30652989(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:30653045-30653046(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:30653069-30653070(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:30653129-30653130(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30653180-30653181(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30653200-30653201(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30653253-30653254(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30653283-30653284(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30653350-30653351(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30653366-30653367(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30653426-30653427(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30653532-30653533(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30653583-30653584(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960
chr6:30653591-30653592(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960
chr6:30653605-30653606(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960
chr6:30653778-30653779(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536
chr6:30654055-30654056(-) m6A 5'UTR//intron       24284625//24209618//24981863//28052920//27773535//27371828
chr6:30654351-30654352(-) m6A 5'UTR//intron       24284625//24209618//24981863//27371828
chr6:30654434-30654435(-) m6A 5'UTR//intron       24209618//25456834//27371828
chr6:30654609-30654610(-) m6A 5'UTR//intron       24284625//25456834
chr6:30654681-30654682(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828
chr6:30654705-30654706(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828
chr6:30654813-30654814(-) m6A 5'UTR//intron       24284625//27371828
chr6:30654867-30654868(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828
chr6:30655087-30655088(-) m6A 5'UTR       24284625//24981863
chr6:30655211-30655212(-) m6A 5'UTR       24981863
chr6:30655223-30655224(-) m6A 5'UTR       24981863
chr6:30655421-30655422(-) m6A 5'UTR       25456834
chr6:30655429-30655430(-) m6A 5'UTR       25456834
chr6:30655443-30655444(-) m6A 5'UTR       25456834
chr6:30655450-30655451(-) m6A 5'UTR       25456834
chr6:30655530-30655531(-) m6A 5'UTR       -
chr6:30655589-30655590(-) m6A 5'UTR       -
chr6:30655600-30655601(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365a-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
PPP1R18
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365a-5p
Interactor2: PPP1R18

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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