Basic Information:

  VIRBase ID:  

HHID00015064

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          UBR3:  NM_172070     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	UBR3
miRBase Accession/Entrez ID	MIMAT0009199	130507
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ZNF650

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UBR3	chr2:170728842(+) A-I      NonSyn:Ile->Met chr2:170837665(+) A-I      intronic chr2:170837664(+) A-I      intronic chr2:170837658(+) A-I      intronic chr2:170837650(+) A-I      intronic chr2:170837647(+) A-I      intronic chr2:170837640(+) A-I      intronic chr2:170837631(+) A-I      intronic chr2:170837662(+) A-I      intronic chr2:170924839(+) A-I      intronic chr2:170924802(+) A-I      intronic chr2:170924801(+) A-I      intronic chr2:170739037(+) A-I      intronic chr2:170738990(+) A-I      intronic chr2:170727816(+) A-I      intronic chr2:170709302(+) A-I      intronic chr2:170709166(+) A-I      intronic chr2:170709157(+) A-I      intronic chr2:170707747(+) A-I      intronic chr2:170707734(+) A-I      intronic chr2:170707729(+) A-I      intronic chr2:170707721(+) A-I      intronic chr2:170707709(+) A-I      intronic chr2:170707690(+) A-I      intronic chr2:170707683(+) A-I      intronic chr2:170703304(+) A-I      intronic chr2:170703269(+) A-I      intronic chr2:170703266(+) A-I      intronic chr2:170778675(+) A-I      intronic chr2:170750116(+) A-I      intronic chr2:170700597(+) A-I      intronic chr2:170692797(+) A-I      intronic chr2:170690405(+) A-I      intronic chr2:170690387(+) A-I      intronic chr2:170690373(+) A-I      intronic chr2:170690368(+) A-I      intronic chr2:170689183(+) A-I      intronic chr2:170837712(+) A-I      intronic chr2:170837695(+) A-I      intronic chr2:170837668(+) A-I      intronic chr2:170910715(+) A-I      intronic chr2:170902666(+) A-I      intronic chr2:170902594(+) A-I      intronic chr2:170902581(+) A-I      intronic chr2:170902577(+) A-I      intronic chr2:170902576(+) A-I      intronic chr2:170739120(+) A-I      intronic chr2:170739157(+) A-I      intronic chr2:170880785(+) A-I      intronic chr2:170740460(+) A-I      intronic chr2:170740719(+) A-I      intronic chr2:170750088(+) A-I      intronic chr2:170750096(+) A-I      intronic chr2:170750648(+) A-I      intronic chr2:170750729(+) A-I      intronic chr2:170750758(+) A-I      intronic chr2:170774299(+) A-I      intronic chr2:170774313(+) A-I      intronic chr2:170774342(+) A-I      intronic chr2:170774418(+) A-I      intronic chr2:170778352(+) A-I      intronic chr2:170778355(+) A-I      intronic chr2:170778367(+) A-I      intronic chr2:170778397(+) A-I      intronic chr2:170785909(+) A-I      intronic chr2:170785924(+) A-I      intronic chr2:170785955(+) A-I      intronic chr2:170786014(+) A-I      intronic chr2:170786997(+) A-I      intronic chr2:170787023(+) A-I      intronic chr2:170787046(+) A-I      intronic chr2:170787062(+) A-I      intronic chr2:170787130(+) A-I      intronic chr2:170788705(+) A-I      intronic chr2:170788717(+) A-I      intronic chr2:170791707(+) A-I      intronic chr2:170791957(+) A-I      intronic chr2:170810804(+) A-I      intronic chr2:170812245(+) A-I      intronic chr2:170812249(+) A-I      intronic chr2:170880743(+) A-I      intronic chr2:170880686(+) A-I      intronic chr2:170880242(+) A-I      intronic chr2:170727831(+) A-I      intronic chr2:170723138(+) A-I      intronic chr2:170702222(+) A-I      intronic chr2:170702170(+) A-I      intronic chr2:170701830(+) A-I      intronic chr2:170701782(+) A-I      intronic chr2:170880203(+) A-I      intronic chr2:170880059(+) A-I      intronic chr2:170880024(+) A-I      intronic chr2:170693893(+) A-I      intronic chr2:170693811(+) A-I      intronic chr2:170721712(+) A-I      intronic chr2:170721508(+) A-I      intronic chr2:170737819(+) A-I      intronic chr2:170737826(+) A-I      intronic chr2:170817928(+) A-I      intronic chr2:170848234(+) A-I      intronic chr2:170848274(+) A-I      intronic chr2:170848291(+) A-I      intronic chr2:170848299(+) A-I      intronic chr2:170858150(+) A-I      intronic chr2:170858151(+) A-I      intronic chr2:170858196(+) A-I      intronic chr2:170858258(+) A-I      intronic chr2:170858263(+) A-I      intronic chr2:170858264(+) A-I      intronic chr2:170858281(+) A-I      intronic chr2:170858380(+) A-I      intronic chr2:170859387(+) A-I      intronic chr2:170860225(+) A-I      intronic chr2:170860230(+) A-I      intronic chr2:170860357(+) A-I      intronic chr2:170861171(+) A-I      intronic chr2:170880020(+) A-I      intronic chr2:170880019(+) A-I      intronic chr2:170876415(+) A-I      intronic chr2:170875955(+) A-I      intronic chr2:170861243(+) A-I      intronic chr2:170739001(+) A-I      intronic chr2:170739026(+) A-I      intronic chr2:170739104(+) A-I      intronic chr2:170721502(+) A-I      intronic chr2:170721498(+) A-I      intronic chr2:170721485(+) A-I      intronic chr2:170721377(+) A-I      intronic chr2:170721313(+) A-I      intronic chr2:170721296(+) A-I      intronic chr2:170721278(+) A-I      intronic chr2:170720730(+) A-I      intronic chr2:170720711(+) A-I      intronic chr2:170714069(+) A-I      intronic chr2:170714066(+) A-I      intronic chr2:170709250(+) A-I      intronic chr2:170709197(+) A-I      intronic chr2:170709175(+) A-I      intronic chr2:170693807(+) A-I      intronic chr2:170709143(+) A-I      intronic chr2:170709124(+) A-I      intronic chr2:170708298(+) A-I      intronic chr2:170693758(+) A-I      intronic chr2:170693732(+) A-I      intronic chr2:170690541(+) A-I      intronic chr2:170688939(+) A-I      intronic chr2:170686196(+) A-I      intronic chr2:170685990(+) A-I      intronic chr2:170685978(+) A-I      intronic chr2:170880268(+) A-I      intronic chr2:170917997(+) A-I      intronic chr2:170734768(+) A-I      intronic chr2:170703342(+) A-I      intronic chr2:170703177(+) A-I      intronic chr2:170703100(+) A-I      intronic chr2:170702346(+) A-I      intronic chr2:170918187(+) A-I      intronic chr2:170702330(+) A-I      intronic chr2:170702308(+) A-I      intronic chr2:170737807(+) A-I      intronic chr2:170737776(+) A-I      intronic chr2:170734685(+) A-I      intronic chr2:170730033(+) A-I      intronic chr2:170918158(+) A-I      intronic chr2:170918143(+) A-I      intronic chr2:170918123(+) A-I      intronic chr2:170918095(+) A-I      intronic chr2:170918078(+) A-I      intronic chr2:170918039(+) A-I      intronic chr2:170729927(+) A-I      intronic chr2:170911014(+) A-I      intronic chr2:170910918(+) A-I      intronic chr2:170910891(+) A-I      intronic chr2:170708268(+) A-I      intronic chr2:170707239(+) A-I      intronic chr2:170705306(+) A-I      intronic chr2:170721096(+) A-I      intronic chr2:170708254(+) A-I      intronic chr2:170812224(+) A-I      intronic chr2:170705352(+) A-I      intronic chr2:170690562(+) A-I      intronic chr2:170701794(+) A-I      intronic chr2:170924792(+) A-I      intronic chr2:170709098(+) A-I      intronic chr2:170705985(+) A-I      intronic chr2:170860424(+) A-I      intronic chr2:170918071(+) A-I      intronic chr2:170771926(+) A-I      intronic chr2:170921962(+) A-I      intronic chr2:170700656(+) A-I      intronic chr2:170721101(+) A-I      intronic chr2:170876412(+) A-I      intronic chr2:170786996(+) A-I      intronic chr2:170692031(+) A-I      intronic chr2:170910712(+) A-I      intronic chr2:170727780(+) A-I      intronic chr2:170717981(+) A-I      intronic chr2:170722643(+) A-I      intronic chr2:170708120(+) A-I      intronic chr2:170734715(+) A-I      intronic chr2:170706728(+) A-I      intronic chr2:170702145(+) A-I      intronic chr2:170727821(+) A-I      intronic chr2:170709241(+) A-I      intronic chr2:170742032(+) A-I      intronic chr2:170924910(+) A-I      intronic chr2:170876355(+) A-I      intronic chr2:170781455(+) A-I      intronic chr2:170702221(+) A-I      intronic chr2:170876008(+) A-I      intronic chr2:170725973(+) A-I      intronic chr2:170880714(+) A-I      intronic chr2:170689345(+) A-I      intronic chr2:170817940(+) A-I      intronic chr2:170853272(+) A-I      intronic chr2:170737724(+) A-I      intronic chr2:170856516(+) A-I      intronic chr2:170876474(+) A-I      intronic chr2:170812048(+) A-I      intronic chr2:170876114(+) A-I      intronic chr2:170910892(+) A-I      intronic chr2:170918212(+) A-I      intronic chr2:170880889(+) A-I      intronic chr2:170911766(+) A-I      intronic chr2:170727813(+) A-I      intronic chr2:170708269(+) A-I      intronic chr2:170876048(+) A-I      intronic chr2:170876088(+) A-I      intronic chr2:170692045(+) A-I      intronic chr2:170810890(+) A-I      intronic chr2:170876435(+) A-I      intronic chr2:170722453(+) A-I      intronic chr2:170858329(+) A-I      intronic chr2:170775066(+) A-I      intronic chr2:170706763(+) A-I      intronic chr2:170738996(+) A-I      intronic chr2:170689190(+) A-I      intronic chr2:170707105(+) A-I      intronic chr2:170918258(+) A-I      intronic chr2:170858355(+) A-I      intronic chr2:170720599(+) A-I      intronic chr2:170858284(+) A-I      intronic chr2:170709176(+) A-I      intronic chr2:170817875(+) A-I      intronic chr2:170701790(+) A-I      intronic chr2:170858302(+) A-I      intronic chr2:170924913(+) A-I      intronic chr2:170701812(+) A-I      intronic chr2:170876529(+) A-I      intronic chr2:170740508(+) A-I      intronic chr2:170861143(+) A-I      intronic chr2:170860418(+) A-I      intronic chr2:170778741(+) A-I      intronic chr2:170858303(+) A-I      intronic chr2:170702362(+) A-I      intronic chr2:170918033(+) A-I      intronic chr2:170739182(+) A-I      intronic chr2:170760276(+) A-I      intronic chr2:170703377(+) A-I      intronic chr2:170924867(+) A-I      intronic chr2:170750277(+) A-I      intronic chr2:170787134(+) A-I      intronic chr2:170876115(+) A-I      intronic chr2:170739185(+) A-I      intronic chr2:170709286(+) A-I      intronic chr2:170701826(+) A-I      intronic chr2:170701737(+) A-I      intronic chr2:170717997(+) A-I      intronic chr2:170690422(+) A-I      intronic chr2:170701848(+) A-I      intronic chr2:170721725(+) A-I      intronic chr2:170876419(+) A-I      intronic chr2:170727747(+) A-I      intronic chr2:170691832(+) A-I      intronic chr2:170924857(+) A-I      intronic chr2:170750710(+) A-I      intronic chr2:170750747(+) A-I      intronic chr2:170860206(+) A-I      intronic chr2:170750128(+) A-I      intronic chr2:170911626(+) A-I      intronic chr2:170722465(+) A-I      intronic chr2:170703274(+) A-I      intronic chr2:170728200(+) A-I      intronic chr2:170740869(+) A-I      intronic chr2:170707100(+) A-I      intronic chr2:170740740(+) A-I      intronic chr2:170739112(+) A-I      intronic chr2:170880653(+) A-I      intronic chr2:170876350(+) A-I      intronic chr2:170739144(+) A-I      intronic chr2:170750712(+) A-I      intronic chr2:170880640(+) A-I      intronic chr2:170918240(+) A-I      intronic chr2:170858245(+) A-I      intronic chr2:170692030(+) A-I      intronic chr2:170706950(+) A-I      intronic chr2:170690498(+) A-I      intronic chr2:170723012(+) A-I      intronic chr2:170880753(+) A-I      intronic chr2:170778541(+) A-I      intronic chr2:170707735(+) A-I      intronic chr2:170898986(+) A-I      intronic chr2:170738995(+) A-I      intronic chr2:170701865(+) A-I      intronic chr2:170910921(+) A-I      intronic chr2:170812184(+) A-I      intronic chr2:170706963(+) A-I      intronic chr2:170706801(+) A-I      intronic chr2:170741971(+) A-I      intronic chr2:170692051(+) A-I      intronic chr2:170875956(+) A-I      intronic chr2:170750774(+) A-I      intronic chr2:170880701(+) A-I      intronic chr2:170785934(+) A-I      intronic chr2:170876123(+) A-I      intronic chr2:170918041(+) A-I      intronic chr2:170727875(+) A-I      intronic chr2:170709240(+) A-I      intronic chr2:170722954(+) A-I      intronic chr2:170707207(+) A-I      intronic chr2:170778539(+) A-I      intronic chr2:170707275(+) A-I      intronic chr2:170796105(+) A-I      intronic chr2:170760275(+) A-I      intronic chr2:170750644(+) A-I      intronic chr2:170876386(+) A-I      intronic chr2:170722990(+) A-I      intronic chr2:170741948(+) A-I      intronic chr2:170707742(+) A-I      intronic chr2:170722985(+) A-I      intronic chr2:170703372(+) A-I      intronic chr2:170728203(+) A-I      intronic chr2:170858156(+) A-I      intronic chr2:170924893(+) A-I      intronic chr2:170690419(+) A-I      intronic chr2:170688981(+) A-I      intronic chr2:170880717(+) A-I      intronic chr2:170742612(+) A-I      intronic chr2:170903781(+) A-I      intronic chr2:170739131(+) A-I      intronic chr2:170723108(+) A-I      intronic chr2:170876385(+) A-I      intronic chr2:170750189(+) A-I      intronic chr2:170727784(+) A-I      intronic chr2:170709282(+) A-I      intronic chr2:170692869(+) A-I      intronic chr2:170707260(+) A-I      intronic chr2:170727812(+) A-I      intronic chr2:170918107(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UBR3	chr2:170924871(+) A-I intron -    22327324 chr2:170797963(+) A-G intron -    22484847 chr2:170837649(+) A-G intron -    22484847 chr2:170837670(+) A-G intron -    22484847 chr2:170923534(+) A-G intron -    22484847 chr2:170687829(+) C-T intron -    22484847 chr2:170689190(+) A-G intron -    22484847 chr2:170690419(+) A-G intron -    22484847 chr2:170690422(+) A-G intron -    22484847 chr2:170691787(+) A-G intron -    22484847 chr2:170692051(+) A-G intron -    22484847 chr2:170701790(+) A-G intron -    22484847 chr2:170701794(+) A-G intron -    22484847 chr2:170702221(+) A-G intron -    22484847 chr2:170702362(+) A-G intron -    22484847 chr2:170703062(+) A-G intron -    22484847 chr2:170703372(+) A-G intron -    22484847 chr2:170703373(+) A-G intron -    22484847 chr2:170707207(+) A-G intron -    22484847 chr2:170720579(+) A-G intron -    22484847 chr2:170720668(+) A-G intron -    22484847 chr2:170722482(+) A-G intron -    22484847 chr2:170723108(+) A-G intron -    22484847 chr2:170739193(+) A-G intron -    22484847 chr2:170740436(+) A-G intron -    22484847 chr2:170750128(+) A-G intron -    22484847 chr2:170755645(+) T-C intron -    22484847 chr2:170809122(+) T-C intron -    22484847 chr2:170809123(+) T-C intron -    22484847 chr2:170809129(+) T-C intron -    22484847 chr2:170839966(+) T-C intron -    22484847 chr2:170848213(+) T-C intron -    22484847 chr2:170875956(+) A-G intron -    22484847 chr2:170876029(+) T-C intron -    22484847 chr2:170876088(+) A-G intron -    22484847 chr2:170876114(+) A-G intron -    22484847 chr2:170876123(+) A-G intron -    22484847 chr2:170876336(+) A-G intron -    22484847 chr2:170876350(+) A-G intron -    22484847 chr2:170876355(+) A-G intron -    22484847 chr2:170876385(+) A-G intron -    22484847 chr2:170876386(+) A-G intron -    22484847 chr2:170876412(+) A-G intron -    22484847 chr2:170876419(+) A-G intron -    22484847 chr2:170876435(+) A-G intron -    22484847 chr2:170876474(+) A-G intron -    22484847 chr2:170879951(+) A-G intron -    22484847 chr2:170880640(+) A-G intron -    22484847 chr2:170880744(+) A-G intron -    22484847 chr2:170910712(+) A-G intron -    22484847 chr2:170910892(+) A-G intron -    22484847 chr2:170910921(+) A-G intron -    22484847 chr2:170911670(+) A-G intron -    22484847 chr2:170913718(+) T-C intron -    22484847 chr2:170918071(+) A-G intron -    22484847 chr2:170918107(+) A-G intron -    22484847 chr2:170918144(+) A-G intron -    22484847 chr2:170924349(+) A-G intron -    22484847 chr2:170924417(+) T-C intron -    22484847 chr2:170924483(+) T-C intron -    22484847 chr2:170924856(+) T-C intron -    22484847 chr2:170924857(+) A-G intron -    22484847 chr2:170924862(+) T-C intron -    22484847 chr2:170924871(+) A-G intron -    22484847 chr2:170924913(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UBR3	chr2:170683992-170683993(+) m6A 5'UTR       24981863 chr2:170684096-170684097(+) m6A CDS       24981863 chr2:170684389-170684390(+) m6A CDS       24209618 chr2:170747721-170747722(+) m6A CDS       24981863 chr2:170806135-170806136(+) Y CDS//exon       26075521 chr2:170806222-170806223(+) m6A CDS//exon       24284625//24981863//22608085 chr2:170806314-170806315(+) m6A CDS//exon       24284625//24981863//22608085 chr2:170806326-170806327(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr2:170806338-170806339(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr2:170806343-170806344(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr2:170806475-170806476(+) m6A CDS//exon       24981863//27773535//22608085 chr2:170806555-170806556(+) m6A CDS//exon       24981863//27773535 chr2:170806562-170806563(+) m6A CDS//exon       24981863 chr2:170865319-170865320(+) m6A 3'UTR//CDS       24981863 chr2:170865389-170865390(+) m6A 3'UTR//CDS       24981863 chr2:170865400-170865401(+) m6A 3'UTR//CDS       24981863 chr2:170865416-170865417(+) m6A 3'UTR//CDS       24981863 chr2:170939620-170939621(+) m6A 3'UTR//exon       24981863 chr2:170939668-170939669(+) m6A 3'UTR//exon       24981863 chr2:170939673-170939674(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	UBR3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: UBR3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).