Basic Information:

  VIRBase ID:  

HHID00015047

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          NAA30:  NM_001011713     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	NAA30
miRBase Accession/Entrez ID	MIMAT0009199	122830
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C14orf35//MAK3//Mak3p//NAT12//NAT12P

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NAA30	chr14:57873738(+) A-I      intronic chr14:57873753(+) A-I      intronic chr14:57873723(+) A-I      intronic chr14:57873757(+) A-I      intronic chr14:57873737(+) A-I      intronic chr14:57873741(+) A-I      intronic chr14:57873697(+) A-I      intronic chr14:57864412(+) A-I      intronic chr14:57865301(+) A-I      intronic chr14:57865302(+) A-I      intronic chr14:57865321(+) A-I      intronic chr14:57865315(+) A-I      intronic chr14:57873634(+) A-I      intronic chr14:57864416(+) A-I      intronic chr14:57865199(+) A-I      intronic chr14:57864564(+) A-I      intronic chr14:57864555(+) A-I      intronic chr14:57864623(+) A-I      intronic chr14:57870920(+) A-I      intronic chr14:57865450(+) A-I      intronic chr14:57864390(+) A-I      intronic chr14:57865212(+) A-I      intronic chr14:57865195(+) A-I      intronic chr14:57864457(+) A-I      intronic chr14:57865664(+) A-I      intronic chr14:57870961(+) A-I      intronic chr14:57864387(+) A-I      intronic chr14:57873659(+) A-I      intronic chr14:57873746(+) A-I      intronic chr14:57864467(+) A-I      intronic chr14:57870946(+) A-I      intronic chr14:57865476(+) A-I      intronic chr14:57876733(+) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NAA30	chr14:57857272-57857273(+) m6A 5'UTR       25456834//24981863 chr14:57857326-57857327(+) m6A 5'UTR       24209618//25456834//24981863 chr14:57857412-57857413(+) m6A 5'UTR       24209618//25456834//24981863 chr14:57857947-57857948(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr14:57858116-57858117(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:57858178-57858179(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:57858361-57858362(+) m6A CDS//intron       24284625//24981863//26404942//22608085 chr14:57858385-57858386(+) m6A CDS//intron       24284625//24981863//26404942//22608085 chr14:57866590-57866591(+) m6A CDS//intron       24209618//24981863//22608085 chr14:57876108-57876109(+) m6A CDS       24209618//24981863//22608085 chr14:57876137-57876138(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr14:57876218-57876219(+) m6A 3'UTR//CDS       24981863//26404942//22608085 chr14:57876237-57876238(+) m6A 3'UTR       24981863//26404942//22608085 chr14:57876251-57876252(+) m6A 3'UTR       24981863//26404942//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	NAA30	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: NAA30

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).