Detail Information

Basic Information:


  VIRBase ID:  

HHID00015006

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:           DDX60L:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365a-5p DDX60L
miRBase
Accession/Entrez ID		 MIMAT0009199 91351
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365a-5p
rs1166908611 chr16:14309308    T/C
rs1368596991 chr16:14309314    G/A
rs1380926089 chr16:14309318    A/G
rs1396179427 chr16:14309310    G/C
rs1428928383 chr16:14309320    G/A
rs773834113 chr16:14309301    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DDX60L
chr4:169307310(-) A-I      intronic
chr4:169307375(-) A-I      intronic
chr4:169305538(-) A-I      intronic
chr4:169305576(-) A-I      intronic
chr4:169350363(-) A-I      intronic
chr4:169351127(-) A-I      intronic
chr4:169351132(-) A-I      intronic
chr4:169351123(-) A-I      intronic
chr4:169305529(-) A-I      intronic
chr4:169307302(-) A-I      intronic
chr4:169350528(-) A-I      intronic
chr4:169305555(-) A-I      intronic
chr4:169279864(-) A-I      intronic
chr4:169285804(-) A-I      intronic
chr4:169350326(-) A-I      intronic
chr4:169279889(-) A-I      intronic
chr4:169385630(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DDX60L
chr4:169277954-169277955(-) m6A 3'UTR//exon       27773535
chr4:169277968-169277969(-) m6A 3'UTR//exon       27773535
chr4:169278031-169278032(-) m6A 3'UTR//exon       27773535
chr4:169278177-169278178(-) m6A 3'UTR//exon       27773535
chr4:169278199-169278200(-) m6A 3'UTR//exon       27773535
chr4:169278213-169278214(-) m6A 3'UTR//exon       27773535
chr4:169278225-169278226(-) m6A 3'UTR//exon       27773535
chr4:169278276-169278277(-) m6A 3'UTR//exon       27773535
chr4:169278424-169278425(-) m6A 3'UTR//exon       27773535
chr4:169278447-169278448(-) m6A 3'UTR//exon       27773535
chr4:169278470-169278471(-) m6A 3'UTR//exon       24981863//27773535
chr4:169278562-169278563(-) m6A 3'UTR//exon       24981863//27773535
chr4:169278590-169278591(-) m6A 3'UTR//exon       24981863//27773535//27371828
chr4:169278614-169278615(-) m6A 3'UTR//exon       24981863//27773535//27371828
chr4:169278685-169278686(-) m6A 3'UTR//exon       24981863//27773535
chr4:169278814-169278815(-) m6A 3'UTR//exon       24981863//27773535
chr4:169278828-169278829(-) m6A 3'UTR//exon       24981863//27773535
chr4:169278847-169278848(-) m6A 3'UTR//exon       24981863//27773535
chr4:169278871-169278872(-) m6A 3'UTR//exon       24981863//27773535
chr4:169278888-169278889(-) m6A 3'UTR//exon       24981863//27773535
chr4:169279094-169279095(-) m6A 3'UTR//exon       24981863//27773535
chr4:169279178-169279179(-) m6A 3'UTR//exon       24981863
chr4:169279188-169279189(-) m6A 3'UTR//exon       24981863
chr4:169315717-169315718(-) m6A CDS       24981863//27773535
chr4:169315729-169315730(-) m6A CDS       24981863//27773535
chr4:169348408-169348409(-) m6A CDS       24981863
chr4:169410254-169410255(-) m6A exon//intron       27773535
chr4:169410321-169410322(-) m6A exon//intron       27773535
chr4:169410364-169410365(-) m6A exon//intron       27773535
chr4:169410385-169410386(-) m6A exon//intron       27773535
chr4:169451783-169451784(-) m6A exon//intron       27773535
chr4:169451793-169451794(-) m6A exon//intron       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365a-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
DDX60L
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365a-5p
Interactor2: DDX60L

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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