Basic Information:

  VIRBase ID:  

HHID00014891

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          MANEA:  NM_024641     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	MANEA
miRBase Accession/Entrez ID	MIMAT0009199	79694
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ENDO//hEndo

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MANEA	chr6:96033329(+) A-I      intronic chr6:96033286(+) A-I      intronic chr6:96033420(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MANEA	chr6:96034281-96034282(+) m6A 5'UTR       24284625//22608085 chr6:96034336-96034337(+) m6A CDS       24284625//24981863//22608085 chr6:96034404-96034405(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085 chr6:96034437-96034438(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085 chr6:96034455-96034456(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:96034468-96034469(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:96034525-96034526(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:96034566-96034567(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr6:96034584-96034585(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr6:96034599-96034600(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr6:96034613-96034614(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr6:96034709-96034710(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr6:96034743-96034744(+) m6A CDS       24284625//24209618//24981863//26404942//22608085 chr6:96034825-96034826(+) m6A CDS       24981863//22608085 chr6:96034836-96034837(+) m6A CDS       24981863//22608085 chr6:96053782-96053783(+) m6A CDS//exon       24981863//22608085 chr6:96053812-96053813(+) m6A CDS//exon       24284625//24981863//22608085 chr6:96053997-96053998(+) m6A CDS       24284625//24209618//24981863//22608085 chr6:96054006-96054007(+) m6A CDS       24284625//24209618//24981863//22608085 chr6:96054015-96054016(+) m6A CDS       24284625//24209618//24981863//22608085 chr6:96054065-96054066(+) m6A CDS       24284625//24981863//26404942//22608085 chr6:96054116-96054117(+) m6A CDS       24284625//24981863//26404942//22608085 chr6:96054146-96054147(+) m6A CDS       24284625//24981863//26404942//22608085 chr6:96054184-96054185(+) m6A CDS       24284625//24981863//22608085 chr6:96054202-96054203(+) m6A CDS       24284625//24981863//22608085 chr6:96056837-96056838(+) Cm 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	MANEA	Exosome Blood     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: MANEA

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).