Basic Information:

  VIRBase ID:  

HHID00014801

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          SLC24A3:  NM_020689     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	SLC24A3
miRBase Accession/Entrez ID	MIMAT0009199	57419
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	NCKX3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC24A3	chr20:19692785(+) A-I      intronic chr20:19692792(+) A-I      intronic chr20:19692795(+) A-I      intronic chr20:19694837(+) A-I      intronic chr20:19694846(+) A-I      intronic chr20:19694851(+) A-I      intronic chr20:19555781(+) A-I      intronic chr20:19305999(+) A-I      intronic chr20:19317204(+) A-I      intronic chr20:19317230(+) A-I      intronic chr20:19317109(+) A-I      intronic chr20:19692877(+) A-I      intronic chr20:19581525(+) A-I      intronic chr20:19646984(+) A-I      intronic chr20:19305979(+) A-I      intronic chr20:19557825(+) A-I      intronic chr20:19692778(+) A-I      intronic chr20:19317110(+) A-I      intronic chr20:19692690(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC24A3	chr20:19665855-19665856(+) m6A CDS       25456834 chr20:19665872-19665873(+) m6A CDS       25456834//24981863 chr20:19665911-19665912(+) m6A CDS       25456834//24981863 chr20:19665930-19665931(+) m6A CDS       25456834//24981863 chr20:19702010-19702011(+) m6A 3'UTR       24981863 chr20:19702050-19702051(+) m6A 3'UTR       25456834//24981863 chr20:19702073-19702074(+) m6A 3'UTR       25456834//24981863 chr20:19702148-19702149(+) m6A 3'UTR       24981863 chr20:19702171-19702172(+) m6A 3'UTR       - chr20:19702821-19702822(+) m6A 3'UTR       - chr20:19702912-19702913(+) m6A 3'UTR       25456834 chr20:19703020-19703021(+) m6A 3'UTR       25456834//24981863 chr20:19703027-19703028(+) m6A 3'UTR       25456834//24981863 chr20:19703042-19703043(+) m6A 3'UTR       25456834//24981863 chr20:19703065-19703066(+) m6A 3'UTR       25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	SLC24A3	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: SLC24A3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).