Basic Information:

  VIRBase ID:  

HHID00014798

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          RCN3:  NM_020650     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	RCN3
miRBase Accession/Entrez ID	MIMAT0009199	57333
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	RLP49

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RCN3	chr19:50032420(+) A-I      intronic chr19:50032408(+) A-I      intronic chr19:50032395(+) A-I      intronic chr19:50032253(+) A-I      intronic chr19:50032252(+) A-I      intronic chr19:50032238(+) A-I      intronic chr19:50034491(+) A-I      intronic chr19:50032422(+) A-I      intronic chr19:50032421(+) A-I      intronic chr19:50034437(+) A-I      intronic chr19:50034558(+) A-I      intronic chr19:50044958(+) A-I      intronic chr19:50044281(+) A-I      intronic chr19:50043784(+) A-I      intronic chr19:50043619(+) A-I      intronic chr19:50043613(+) A-I      intronic chr19:50039471(+) A-I      intronic chr19:50036037(+) A-I      intronic chr19:50035207(+) A-I      intronic chr19:50034563(+) A-I      intronic chr19:50032263(+) A-I      intronic chr19:50032383(+) A-I      intronic chr19:50043783(+) A-I      intronic chr19:50032387(+) A-I      intronic chr19:50032389(+) A-I      intronic chr19:50044820(+) A-I      intronic chr19:50043717(+) A-I      intronic chr19:50034455(+) A-I      intronic chr19:50033248(+) A-I      intronic chr19:50040903(+) A-I      intronic chr19:50043986(+) A-I      intronic chr19:50043629(+) A-I      intronic chr19:50044885(+) A-I      intronic chr19:50044461(+) A-I      intronic chr19:50044268(+) A-I      intronic chr19:50038906(+) A-I      intronic chr19:50035319(+) A-I      intronic chr19:50040936(+) A-I      intronic chr19:50036130(+) A-I      intronic chr19:50034423(+) A-I      intronic chr19:50035762(+) A-I      intronic chr19:50034398(+) A-I      intronic chr19:50044841(+) A-I      intronic chr19:50035332(+) A-I      intronic chr19:50039344(+) A-I      intronic chr19:50035138(+) A-I      intronic chr19:50035813(+) A-I      intronic chr19:50043762(+) A-I      intronic chr19:50043515(+) A-I      intronic chr19:50043974(+) A-I      intronic chr19:50035269(+) A-I      intronic chr19:50035994(+) A-I      intronic chr19:50034525(+) A-I      intronic chr19:50044984(+) A-I      intronic chr19:50044886(+) A-I      intronic chr19:50044931(+) A-I      intronic chr19:50036194(+) A-I      intronic chr19:50044340(+) A-I      intronic chr19:50043960(+) A-I      intronic chr19:50045345(+) A-I      intronic chr19:50035265(+) A-I      intronic chr19:50044367(+) A-I      intronic chr19:50044361(+) A-I      intronic chr19:50043675(+) A-I      intronic chr19:50044292(+) A-I      intronic chr19:50041829(+) A-I      intronic chr19:50034373(+) A-I      intronic chr19:50043856(+) A-I      intronic chr19:50034429(+) A-I      intronic chr19:50045391(+) A-I      intronic chr19:50034420(+) A-I      intronic chr19:50034392(+) A-I      intronic chr19:50034551(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RCN3	chr19:50031725-50031726(+) m6A 5'UTR       24284625//24209618//25456834//24981863 chr19:50031880-50031881(+) m6A CDS//exon       24284625//24209618 chr19:50037460-50037461(+) m6A CDS//intron       24284625//24209618 chr19:50037469-50037470(+) m6A CDS//intron       24284625//24209618 chr19:50037553-50037554(+) m6A CDS//intron       24284625//24209618 chr19:50037574-50037575(+) m6A CDS//intron       24284625//24209618 chr19:50037589-50037590(+) m6A CDS//intron       24284625//24209618 chr19:50040321-50040322(+) m6A CDS//exon       24284625//24209618 chr19:50040382-50040383(+) m6A CDS       24284625//24209618 chr19:50040448-50040449(+) m6A CDS       24284625//24209618 chr19:50042378-50042379(+) m6A CDS//intron       24284625//24209618 chr19:50042388-50042389(+) m6A CDS//intron       24284625//24209618//25456834 chr19:50042394-50042395(+) m6A CDS//intron       24284625//24209618//25456834 chr19:50042400-50042401(+) m6A CDS//intron       24284625//24209618//25456834 chr19:50045881-50045882(+) m6A CDS//intron       24284625//24209618//25456834 chr19:50045896-50045897(+) m6A CDS//intron       24284625//24209618//25456834 chr19:50045956-50045957(+) m6A CDS//intron       24284625//24209618//25456834 chr19:50046004-50046005(+) m6A CDS//intron       24284625//24209618//25456834 chr19:50046402-50046403(+) m6A CDS//intron       24284625//24209618 chr19:50046441-50046442(+) m6A CDS//intron       24284625 chr19:50046609-50046610(+) m6A 3'UTR//intron       24284625 chr19:50046717-50046718(+) m6A 3'UTR//intron       24284625//25456834//24981863 chr19:50046725-50046726(+) m6A 3'UTR//intron       24284625//25456834//24981863 chr19:50046753-50046754(+) m6A 3'UTR//intron       24284625//25456834//24981863 chr19:50046799-50046800(+) m6A 3'UTR//intron       24284625//25456834//24981863 chr19:50046805-50046806(+) m6A 3'UTR//intron       24284625//25456834//24981863 chr19:50046847-50046848(+) m6A 3'UTR//intron       24284625//25456834//24981863 chr19:50046889-50046890(+) m6A 3'UTR//intron       24284625//25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	RCN3	Exosome Blood     - Membrane HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: RCN3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).