Basic Information:

  VIRBase ID:  

HHID00014787

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          CCDC47:  NM_020198     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	CCDC47
miRBase Accession/Entrez ID	MIMAT0009199	57003
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GK001//MSTP041//THNS

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CCDC47	chr17:61825248(-) A-I      intronic chr17:61825244(-) A-I      intronic chr17:61825229(-) A-I      intronic chr17:61825291(-) A-I      intronic chr17:61825237(-) A-I      intronic chr17:61847458(-) A-I      intronic chr17:61828490(-) A-I      intronic chr17:61839049(-) A-I      intronic chr17:61832788(-) A-I      intronic chr17:61828485(-) A-I      intronic chr17:61828467(-) A-I      intronic chr17:61825267(-) A-I      intronic chr17:61847406(-) A-I      intronic chr17:61826262(-) A-I      intronic chr17:61846320(-) A-I      intronic chr17:61846049(-) A-I      intronic chr17:61845992(-) A-I      intronic chr17:61832423(-) A-I      intronic chr17:61832368(-) A-I      intronic chr17:61826997(-) A-I      intronic chr17:61826987(-) A-I      intronic chr17:61826961(-) A-I      intronic chr17:61846272(-) A-I      intronic chr17:61828332(-) A-I      intronic chr17:61827980(-) A-I      intronic chr17:61847430(-) A-I      intronic chr17:61827320(-) A-I      intronic chr17:61827309(-) A-I      intronic chr17:61845938(-) A-I      intronic chr17:61826943(-) A-I      intronic chr17:61826340(-) A-I      intronic chr17:61826330(-) A-I      intronic chr17:61826317(-) A-I      intronic chr17:61826312(-) A-I      intronic chr17:61826265(-) A-I      intronic chr17:61826234(-) A-I      intronic chr17:61825739(-) A-I      intronic chr17:61825710(-) A-I      intronic chr17:61825677(-) A-I      intronic chr17:61825392(-) A-I      intronic chr17:61825379(-) A-I      intronic chr17:61825352(-) A-I      intronic chr17:61845926(-) A-I      intronic chr17:61832600(-) A-I      intronic chr17:61845906(-) A-I      intronic chr17:61825326(-) A-I      intronic chr17:61846214(-) A-I      intronic chr17:61825282(-) A-I      intronic chr17:61825290(-) A-I      intronic chr17:61825300(-) A-I      intronic chr17:61845827(-) A-I      intronic chr17:61844076(-) A-I      intronic chr17:61840445(-) A-I      intronic chr17:61826189(-) A-I      intronic chr17:61849249(-) A-I      intronic chr17:61849330(-) A-I      intronic chr17:61847429(-) A-I      intronic chr17:61827232(-) A-I      intronic chr17:61847569(-) A-I      intronic chr17:61847413(-) A-I      intronic chr17:61825674(-) A-I      intronic chr17:61849259(-) A-I      intronic chr17:61840800(-) A-I      intronic chr17:61846020(-) A-I      intronic chr17:61846413(-) A-I      intronic chr17:61826979(-) A-I      intronic chr17:61840484(-) A-I      intronic chr17:61847480(-) A-I      intronic chr17:61826311(-) A-I      intronic chr17:61828337(-) A-I      intronic chr17:61844058(-) A-I      intronic chr17:61840555(-) A-I      intronic chr17:61825748(-) A-I      intronic chr17:61847555(-) A-I      intronic chr17:61825610(-) A-I      intronic chr17:61849185(-) A-I      intronic chr17:61844064(-) A-I      intronic chr17:61849752(-) A-I      intronic chr17:61849894(-) A-I      intronic chr17:61846278(-) A-I      intronic chr17:61832061(-) A-I      intronic chr17:61834500(-) A-I      intronic chr17:61828626(-) A-I      intronic chr17:61840520(-) A-I      intronic chr17:61846002(-) A-I      intronic chr17:61825496(-) A-I      intronic chr17:61826298(-) A-I      intronic chr17:61847449(-) A-I      intronic chr17:61825870(-) A-I      intronic chr17:61826915(-) A-I      intronic chr17:61826102(-) A-I      intronic chr17:61826201(-) A-I      intronic chr17:61832564(-) A-I      intronic chr17:61840622(-) A-I      intronic chr17:61834470(-) A-I      intronic chr17:61849382(-) A-I      intronic chr17:61842811(-) A-I      intronic chr17:61840878(-) A-I      intronic chr17:61847445(-) A-I      intronic chr17:61825629(-) A-I      intronic chr17:61827978(-) A-I      intronic chr17:61826226(-) A-I      intronic chr17:61832160(-) A-I      intronic chr17:61826693(-) A-I      intronic chr17:61828693(-) A-I      intronic chr17:61848089(-) A-I      intronic chr17:61834683(-) A-I      intronic chr17:61840438(-) A-I      intronic chr17:61840374(-) A-I      intronic chr17:61828082(-) A-I      intronic chr17:61832207(-) A-I      intronic chr17:61832501(-) A-I      intronic chr17:61845964(-) A-I      intronic chr17:61825331(-) A-I      intronic chr17:61840478(-) A-I      intronic chr17:61827301(-) A-I      intronic chr17:61828373(-) A-I      intronic chr17:61826150(-) A-I      intronic chr17:61849440(-) A-I      intronic chr17:61840624(-) A-I      intronic chr17:61840562(-) A-I      intronic chr17:61826225(-) A-I      intronic chr17:61826646(-) A-I      intronic chr17:61839021(-) A-I      intronic chr17:61832403(-) A-I      intronic chr17:61840661(-) A-I      intronic chr17:61832469(-) A-I      intronic chr17:61844057(-) A-I      intronic chr17:61840482(-) A-I      intronic chr17:61847460(-) A-I      intronic chr17:61826217(-) A-I      intronic chr17:61845813(-) A-I      intronic chr17:61846226(-) A-I      intronic chr17:61828109(-) A-I      intronic chr17:61826151(-) A-I      intronic chr17:61840828(-) A-I      intronic chr17:61849395(-) A-I      intronic chr17:61846013(-) A-I      intronic chr17:61826952(-) A-I      intronic chr17:61846322(-) A-I      intronic chr17:61825293(-) A-I      intronic chr17:61825611(-) A-I      intronic chr17:61840691(-) A-I      intronic chr17:61827057(-) A-I      intronic chr17:61828491(-) A-I      intronic chr17:61827009(-) A-I      intronic chr17:61832186(-) A-I      intronic chr17:61846319(-) A-I      intronic chr17:61827191(-) A-I      intronic chr17:61825637(-) A-I      intronic chr17:61849886(-) A-I      intronic chr17:61849885(-) A-I      intronic chr17:61840486(-) A-I      intronic chr17:61846934(-) A-I      intronic chr17:61840871(-) A-I      intronic chr17:61826704(-) A-I      intronic chr17:61845856(-) A-I      intronic chr17:61849359(-) A-I      intronic chr17:61847375(-) A-I      intronic chr17:61840709(-) A-I      intronic chr17:61825245(-) A-I      intronic chr17:61840929(-) A-I      intronic chr17:61840700(-) A-I      intronic chr17:61825715(-) A-I      intronic chr17:61827253(-) A-I      intronic chr17:61838994(-) A-I      intronic chr17:61825746(-) A-I      intronic chr17:61832438(-) A-I      intronic chr17:61845973(-) A-I      intronic chr17:61826274(-) A-I      intronic chr17:61840698(-) A-I      intronic chr17:61840379(-) A-I      intronic chr17:61828512(-) A-I      intronic chr17:61828513(-) A-I      intronic chr17:61832591(-) A-I      intronic chr17:61840314(-) A-I      intronic chr17:61847484(-) A-I      intronic chr17:61826154(-) A-I      intronic chr17:61845928(-) A-I      intronic chr17:61838922(-) A-I      intronic chr17:61840406(-) A-I      intronic chr17:61849436(-) A-I      intronic chr17:61832012(-) A-I      intronic chr17:61840833(-) A-I      intronic chr17:61832404(-) A-I      intronic chr17:61826208(-) A-I      intronic chr17:61840556(-) A-I      intronic chr17:61840626(-) A-I      intronic chr17:61846392(-) A-I      intronic chr17:61840409(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CCDC47	chr17:61846392(-) A-I intron -    22327324 chr17:61845865(-) A-I intron -    21960545 chr17:61838691(-) G-A exon CDS    21725310 chr17:61825293(-) A-G intron -    22484847 chr17:61825611(-) A-G intron -    22484847 chr17:61825674(-) A-G intron -    22484847 chr17:61828082(-) A-G intron -    22484847 chr17:61840482(-) A-G intron -    22484847 chr17:61840833(-) A-G intron -    22484847 chr17:61840878(-) A-G intron -    22484847 chr17:61846319(-) A-G intron -    22484847 chr17:61846322(-) A-G intron -    22484847 chr17:61846392(-) A-G intron -    22484847 chr17:61847460(-) A-G intron -    22484847 chr17:61848089(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCDC47	chr17:61823581-61823582(-) m6A 3'UTR       26404942 chr17:61823719-61823720(-) m6A 3'UTR       24981863//22608085 chr17:61823743-61823744(-) m6A 3'UTR       24981863//22608085 chr17:61823778-61823779(-) m6A 3'UTR       24981863//22608085 chr17:61823817-61823818(-) m6A 3'UTR       24981863//22608085 chr17:61823828-61823829(-) m6A 3'UTR       24981863//22608085 chr17:61823854-61823855(-) m6A 3'UTR       24981863//22608085 chr17:61824142-61824143(-) m6A 3'UTR       24284625//24981863//26404942//27371828 chr17:61824183-61824184(-) m6A 3'UTR       24284625//24981863//26404942//27773535//27371828 chr17:61824264-61824265(-) m6A CDS       24284625//24981863//28052920//27773535//27371828//22608085 chr17:61829180-61829181(-) m6A 3'UTR//intron       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr17:61829271-61829272(-) m6A CDS//intron       24981863//27773535//27371828//22608085 chr17:61829293-61829294(-) m6A CDS//intron       24981863//27773535//27371828//22608085 chr17:61829314-61829315(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085 chr17:61829395-61829396(-) m6A CDS       24209618//24981863//27773535//27371828//22608085 chr17:61829398-61829399(-) Am CDS       - chr17:61829413-61829414(-) m6A CDS       24209618//24981863//27773535//27371828//22608085 chr17:61829423-61829424(-) m6A CDS       24209618//24981863//27773535//27371828//22608085 chr17:61829444-61829445(-) m6A CDS       24209618//24981863//27773535//27371828//22608085 chr17:61829461-61829462(-) m6A CDS       24981863//27773535 chr17:61829731-61829732(-) m6A CDS       27773535 chr17:61838327-61838328(-) m6A 5'UTR//CDS//exon       22575960 chr17:61838665-61838666(-) m6A 5'UTR//CDS//exon       27773535 chr17:61838699-61838700(-) m6A 5'UTR//CDS//exon       27773535 chr17:61838834-61838835(-) m6A exon//intron       27773535 chr17:61838869-61838870(-) m6A exon//intron       27773535 chr17:61841530-61841531(-) m6A 5'UTR//CDS       26404942 chr17:61842118-61842119(-) m6A 5'UTR//CDS       24981863//26404942//22575960 chr17:61842151-61842152(-) m6A 5'UTR//CDS       24981863//26404942//27773535//22575960 chr17:61842186-61842187(-) m6A CDS       24981863//26404942//27773535//22575960 chr17:61843186-61843187(-) m6A exon//intron       24981863//27773535 chr17:61843215-61843216(-) m6A exon//intron       24981863//27773535//27371828 chr17:61843305-61843306(-) m6A CDS//exon       24981863//27773535//27371828 chr17:61843336-61843337(-) m6A CDS//exon       24981863//27773535//27371828 chr17:61843392-61843393(-) m6A CDS//exon       24981863//26404942//27773535//27371828 chr17:61843446-61843447(-) m6A CDS//exon       27773535 chr17:61850867-61850868(-) m6A 5'UTR//exon//intron       24209618//24981863//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	CCDC47	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: CCDC47

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).