Basic Information:

  VIRBase ID:  

HHID00014764

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          G2E3:  NM_017769     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	G2E3
miRBase Accession/Entrez ID	MIMAT0009199	55632
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	KIAA1333//PHF7B

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	G2E3	chr14:31050810(+) A-I      intronic chr14:31033030(+) A-I      intronic chr14:31067472(+) A-I      intronic chr14:31072814(+) A-I      intronic chr14:31071990(+) A-I      intronic chr14:31033672(+) A-I      intronic chr14:31079671(+) A-I      intronic chr14:31079610(+) A-I      intronic chr14:31071842(+) A-I      intronic chr14:31071838(+) A-I      intronic chr14:31072481(+) A-I      intronic chr14:31079675(+) A-I      intronic chr14:31072428(+) A-I      intronic chr14:31072065(+) A-I      intronic chr14:31072385(+) A-I      intronic chr14:31072381(+) A-I      intronic chr14:31050684(+) A-I      intronic chr14:31050770(+) A-I      intronic chr14:31071973(+) A-I      intronic chr14:31079670(+) A-I      intronic chr14:31072411(+) A-I      intronic chr14:31054155(+) A-I      intronic chr14:31071835(+) A-I      intronic chr14:31033064(+) A-I      intronic chr14:31074159(+) A-I      intronic chr14:31033055(+) A-I      intronic chr14:31071904(+) A-I      intronic chr14:31071935(+) A-I      intronic chr14:31033043(+) A-I      intronic chr14:31072904(+) A-I      intronic chr14:31071873(+) A-I      intronic chr14:31067471(+) A-I      intronic chr14:31074276(+) A-I      intronic chr14:31033651(+) A-I      intronic chr14:31072417(+) A-I      intronic chr14:31071871(+) A-I      intronic chr14:31072380(+) A-I      intronic chr14:31072018(+) A-I      intronic chr14:31072092(+) A-I      intronic chr14:31072477(+) A-I      intronic chr14:31050663(+) A-I      intronic chr14:31079699(+) A-I      intronic chr14:31046280(+) A-I      intronic chr14:31067581(+) A-I      intronic chr14:31072279(+) A-I      intronic chr14:31033044(+) A-I      intronic chr14:31050883(+) A-I      intronic chr14:31071861(+) A-I      intronic chr14:31074242(+) A-I      intronic chr14:31072395(+) A-I      intronic chr14:31067513(+) A-I      intronic chr14:31032982(+) A-I      intronic chr14:31072323(+) A-I      intronic chr14:31072278(+) A-I      intronic chr14:31046320(+) A-I      intronic chr14:31072908(+) A-I      intronic chr14:31054308(+) A-I      intronic chr14:31072052(+) A-I      intronic chr14:31071918(+) A-I      intronic chr14:31072453(+) A-I      intronic chr14:31050704(+) A-I      intronic chr14:31072053(+) A-I      intronic chr14:31071930(+) A-I      intronic chr14:31046269(+) A-I      intronic chr14:31060261(+) A-I      intronic chr14:31071957(+) A-I      intronic chr14:31072992(+) A-I      intronic chr14:31050711(+) A-I      intronic chr14:31072081(+) A-I      intronic chr14:31050635(+) A-I      intronic chr14:31072786(+) A-I      intronic chr14:31072482(+) A-I      intronic chr14:31072382(+) A-I      intronic chr14:31072379(+) A-I      intronic chr14:31072438(+) A-I      intronic chr14:31071879(+) A-I      intronic chr14:31033678(+) A-I      intronic chr14:31033729(+) A-I      intronic chr14:31079750(+) A-I      intronic chr14:31071944(+) A-I      intronic chr14:31086359(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	G2E3	chr14:31080942(+) A-I intron -    22327324 chr14:31080994(+) A-I intron -    22327324 chr14:31064341(+) C-T intron -    22484847 chr14:31071879(+) A-G intron -    22484847 chr14:31072081(+) A-G intron -    22484847 chr14:31072323(+) A-G intron -    22484847 chr14:31072395(+) A-G intron -    22484847 chr14:31072411(+) A-G intron -    22484847 chr14:31080895(+) A-G intron -    22484847 chr14:31080938(+) A-G intron -    22484847 chr14:31080942(+) A-G intron -    22484847 chr14:31080994(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	G2E3	chr14:31072007-31072008(+) m6A exon//intron       24981863 chr14:31072028-31072029(+) m6A exon//intron       24981863 chr14:31072039-31072040(+) m6A exon//intron       24981863 chr14:31084721-31084722(+) m6A CDS//exon       24284625 chr14:31085510-31085511(+) m6A CDS//exon       24284625//22575960//22608085 chr14:31085562-31085563(+) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085 chr14:31085609-31085610(+) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085 chr14:31085675-31085676(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr14:31085690-31085691(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085 chr14:31085700-31085701(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085 chr14:31085733-31085734(+) m6A CDS//exon       24209618//24981863//27773535//22608085 chr14:31085753-31085754(+) m6A 3'UTR//exon       24209618//24981863//22608085 chr14:31085828-31085829(+) m6A 3'UTR//exon       24981863//22608085 chr14:31086451-31086452(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr14:31086471-31086472(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr14:31086503-31086504(+) m6A 3'UTR//exon       24981863//22608085 chr14:31086520-31086521(+) m6A 3'UTR//exon       24981863//22608085 chr14:31086852-31086853(+) m6A 3'UTR//exon       27773535 chr14:31087307-31087308(+) m6A 3'UTR//exon       27773535 chr14:31087313-31087314(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	G2E3	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: G2E3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).