Basic Information:

  VIRBase ID:  

HHID00014737

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          UBR7:  NR_038150     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	UBR7
miRBase Accession/Entrez ID	MIMAT0009199	55148
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C14orf130//LICAS

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UBR7	chr14:93683224(+) A-I      intronic chr14:93681768(+) A-I      intronic chr14:93683141(+) A-I      intronic chr14:93683127(+) A-I      intronic chr14:93684659(+) A-I      intronic chr14:93684630(+) A-I      intronic chr14:93684580(+) A-I      intronic chr14:93684579(+) A-I      intronic chr14:93684531(+) A-I      intronic chr14:93684527(+) A-I      intronic chr14:93681864(+) A-I      intronic chr14:93681870(+) A-I      intronic chr14:93683512(+) A-I      intronic chr14:93683183(+) A-I      intronic chr14:93681941(+) A-I      intronic chr14:93682627(+) A-I      intronic chr14:93684494(+) A-I      intronic chr14:93684342(+) A-I      intronic chr14:93683647(+) A-I      intronic chr14:93688968(+) A-I      intronic chr14:93683534(+) A-I      intronic chr14:93683184(+) A-I      intronic chr14:93683171(+) A-I      intronic chr14:93683150(+) A-I      intronic chr14:93683146(+) A-I      intronic chr14:93681888(+) A-I      intronic chr14:93689501(+) A-I      intronic chr14:93683001(+) A-I      intronic chr14:93684329(+) A-I      intronic chr14:93681950(+) A-I      intronic chr14:93684678(+) A-I      intronic chr14:93680487(+) A-I      intronic chr14:93680331(+) A-I      intronic chr14:93689723(+) A-I      intronic chr14:93679399(+) A-I      intronic chr14:93680342(+) A-I      intronic chr14:93680372(+) A-I      intronic chr14:93686323(+) A-I      intronic chr14:93682985(+) A-I      intronic chr14:93683090(+) A-I      intronic chr14:93677396(+) A-I      intronic chr14:93682666(+) A-I      intronic chr14:93681754(+) A-I      intronic chr14:93688978(+) A-I      intronic chr14:93683074(+) A-I      intronic chr14:93682023(+) A-I      intronic chr14:93684164(+) A-I      intronic chr14:93682581(+) A-I      intronic chr14:93684554(+) A-I      intronic chr14:93683144(+) A-I      intronic chr14:93682652(+) A-I      intronic chr14:93682601(+) A-I      intronic chr14:93677421(+) A-I      intronic chr14:93681820(+) A-I      intronic chr14:93689493(+) A-I      intronic chr14:93679428(+) A-I      intronic chr14:93677426(+) A-I      intronic chr14:93682993(+) A-I      intronic chr14:93683399(+) A-I      intronic chr14:93677373(+) A-I      intronic chr14:93680326(+) A-I      intronic chr14:93681884(+) A-I      intronic chr14:93683118(+) A-I      intronic chr14:93681825(+) A-I      intronic chr14:93689690(+) A-I      intronic chr14:93683126(+) A-I      intronic chr14:93682566(+) A-I      intronic chr14:93687596(+) A-I      intronic chr14:93683242(+) A-I      intronic chr14:93688933(+) A-I      intronic chr14:93684555(+) A-I      intronic chr14:93683085(+) A-I      intronic chr14:93681990(+) A-I      intronic chr14:93687781(+) A-I      intronic chr14:93689621(+) A-I      intronic chr14:93690997(+) A-I      intronic chr14:93683182(+) A-I      intronic chr14:93683015(+) A-I      intronic chr14:93681987(+) A-I      intronic chr14:93683151(+) A-I      intronic chr14:93682672(+) A-I      intronic chr14:93679363(+) A-I      intronic chr14:93677423(+) A-I      intronic chr14:93679373(+) A-I      intronic chr14:93683026(+) A-I      intronic chr14:93679429(+) A-I      intronic chr14:93688942(+) A-I      intronic chr14:93680482(+) A-I      intronic chr14:93683556(+) A-I      intronic chr14:93679728(+) A-I      intronic chr14:93681828(+) A-I      intronic chr14:93684297(+) A-I      intronic chr14:93687640(+) A-I      intronic chr14:93682635(+) A-I      intronic chr14:93689622(+) A-I      intronic chr14:93679425(+) A-I      intronic chr14:93681969(+) A-I      intronic chr14:93683197(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UBR7	chr14:93679363(+) A-I intron -    22327324 chr14:93681888(+) A-I intron -    22327324 chr14:93682666(+) A-I intron -    22327324 chr14:93683118(+) A-I intron -    22327324 chr14:93679363(+) A-G intron -    22484847 chr14:93679373(+) A-G intron -    22484847 chr14:93679425(+) A-G intron -    22484847 chr14:93679428(+) A-G intron -    22484847 chr14:93679429(+) A-G intron -    22484847 chr14:93681828(+) A-G intron -    22484847 chr14:93681870(+) A-G intron -    22484847 chr14:93681888(+) A-G intron -    22484847 chr14:93682581(+) A-G intron -    22484847 chr14:93682627(+) A-G intron -    22484847 chr14:93682635(+) A-G intron -    22484847 chr14:93682652(+) A-G intron -    22484847 chr14:93682666(+) A-G intron -    22484847 chr14:93682672(+) A-G intron -    22484847 chr14:93683026(+) A-G intron -    22484847 chr14:93683118(+) A-G intron -    22484847 chr14:93683126(+) A-G intron -    22484847 chr14:93683197(+) A-G intron -    22484847 chr14:93683242(+) A-G intron -    22484847 chr14:93684554(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UBR7	chr14:93693598-93693599(+) m6A 3'UTR       24981863 chr14:93693761-93693762(+) Y 3'UTR       26075521 chr14:93694370-93694371(+) m6A 3'UTR       24981863 chr14:93694429-93694430(+) m6A 3'UTR       24981863 chr14:93694452-93694453(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	UBR7	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: UBR7

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).