Basic Information:

  VIRBase ID:  

HHID00014731

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          C14orf119:  NM_017924     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	C14orf119
miRBase Accession/Entrez ID	MIMAT0009199	55017
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	C14orf119	chr14:23565927(+) A-I      intronic chr14:23569290(+) A-I      3'UTR chr14:23569288(+) A-I      3'UTR chr14:23569289(+) A-I      3'UTR chr14:23565634(+) A-I      intronic chr14:23565976(+) A-I      intronic chr14:23566048(+) A-I      intronic chr14:23565605(+) A-I      intronic chr14:23565903(+) A-I      intronic chr14:23565919(+) A-I      intronic chr14:23565565(+) A-I      intronic chr14:23565673(+) A-I      intronic chr14:23565566(+) A-I      intronic chr14:23568873(+) A-I      3'UTR chr14:23569342(+) A-I      3'UTR chr14:23569348(+) A-I      3'UTR chr14:23569317(+) A-I      3'UTR chr14:23569409(+) A-I      3'UTR chr14:23568886(+) A-I      3'UTR chr14:23567988(+) A-I      3'UTR chr14:23567904(+) A-I      3'UTR chr14:23568898(+) A-I      3'UTR chr14:23568004(+) A-I      3'UTR chr14:23568872(+) A-I      3'UTR chr14:23568790(+) A-I      3'UTR chr14:23565506(+) A-I      intronic chr14:23565479(+) A-I      intronic chr14:23565462(+) A-I      intronic chr14:23565668(+) A-I      intronic chr14:23565613(+) A-I      intronic chr14:23565885(+) A-I      intronic chr14:23565898(+) A-I      intronic chr14:23565952(+) A-I      intronic chr14:23565960(+) A-I      intronic chr14:23566020(+) A-I      intronic chr14:23565564(+) A-I      intronic chr14:23565969(+) A-I      intronic chr14:23565581(+) A-I      intronic chr14:23565951(+) A-I      intronic chr14:23566007(+) A-I      intronic chr14:23565550(+) A-I      intronic chr14:23565948(+) A-I      intronic chr14:23566025(+) A-I      intronic chr14:23568887(+) A-I      3'UTR chr14:23568793(+) A-I      3'UTR chr14:23568868(+) A-I      3'UTR chr14:23567970(+) A-I      3'UTR chr14:23569259(+) A-I      3'UTR chr14:23569405(+) A-I      3'UTR chr14:23569403(+) A-I      3'UTR chr14:23569270(+) A-I      3'UTR chr14:23567974(+) A-I      3'UTR chr14:23569416(+) A-I      3'UTR chr14:23569378(+) A-I      3'UTR chr14:23568848(+) A-I      3'UTR chr14:23568167(+) A-I      3'UTR chr14:23567951(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	C14orf119	chr14:23566025(+) A-I intron -    22327324 chr14:23567904(+) A-I intron -    21960545 chr14:23568167(+) A-I intron -    21960545 chr14:23566020(+) A-G intron -    22484847 chr14:23566025(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	C14orf119	chr14:23564029-23564030(+) m6A 5'UTR       24981863 chr14:23564448-23564449(+) m6A 5'UTR       24284625//24981863//27773535//22608085 chr14:23564604-23564605(+) m6A 5'UTR       24981863//27773535 chr14:23564653-23564654(+) m6A 5'UTR       24981863//27773535 chr14:23564786-23564787(+) m6A 5'UTR       24284625//24209618//24981863//22575960//22608085 chr14:23567045-23567046(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr14:23567123-23567124(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr14:23567214-23567215(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr14:23567237-23567238(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr14:23567285-23567286(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:23567301-23567302(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:23567384-23567385(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:23567409-23567410(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:23567463-23567464(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr14:23567588-23567589(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr14:23567642-23567643(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr14:23567664-23567665(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr14:23567669-23567670(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr14:23567762-23567763(+) m6A 3'UTR       24284625//24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	C14orf119	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus Nasopharyngeal carcinoma cells     20498841 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: C14orf119

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).