Detail Information

Basic Information:


  VIRBase ID:  

HHID00014717

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:           KLHL28:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365a-5p KLHL28
miRBase
Accession/Entrez ID		 MIMAT0009199 54813
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BTBD5

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365a-5p
rs1166908611 chr16:14309308    T/C
rs1368596991 chr16:14309314    G/A
rs1380926089 chr16:14309318    A/G
rs1396179427 chr16:14309310    G/C
rs1428928383 chr16:14309320    G/A
rs773834113 chr16:14309301    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KLHL28
chr14:45406451(-) A-I      intronic
chr14:45410120(-) A-I      intronic
chr14:45410131(-) A-I      intronic
chr14:45412784(-) A-I      intronic
chr14:45410134(-) A-I      intronic
chr14:45415760(-) A-I      intronic
chr14:45421329(-) A-I      intronic
chr14:45410137(-) A-I      intronic
chr14:45410163(-) A-I      intronic
chr14:45410675(-) A-I      intronic
chr14:45410755(-) A-I      intronic
chr14:45407703(-) A-I      intronic
chr14:45407707(-) A-I      intronic
chr14:45410769(-) A-I      intronic
chr14:45407713(-) A-I      intronic
chr14:45412797(-) A-I      intronic
chr14:45412808(-) A-I      intronic
chr14:45424906(-) A-I      intronic
chr14:45410181(-) A-I      intronic
chr14:45410578(-) A-I      intronic
chr14:45425397(-) A-I      intronic
chr14:45424744(-) A-I      intronic
chr14:45412639(-) A-I      intronic
chr14:45412656(-) A-I      intronic
chr14:45410251(-) A-I      intronic
chr14:45410289(-) A-I      intronic
chr14:45412777(-) A-I      intronic
chr14:45424776(-) A-I      intronic
chr14:45425453(-) A-I      intronic
chr14:45395992(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED KLHL28
chr14:45410289(-) A-I intron -    21960545
chr14:45395775(-) C-A exon 3'UTR    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KLHL28
chr14:45397623-45397624(-) m6A 3'UTR       27773535
chr14:45397747-45397748(-) m6A 3'UTR       24981863//27773535
chr14:45397806-45397807(-) m6A 3'UTR       24981863//27773535
chr14:45397922-45397923(-) m6A 3'UTR       24981863//27773535//22608085
chr14:45397963-45397964(-) m6A 3'UTR       24981863//27773535//22608085
chr14:45397999-45398000(-) m6A 3'UTR       24981863//27773535//22608085
chr14:45398153-45398154(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr14:45398179-45398180(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr14:45398194-45398195(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr14:45398220-45398221(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr14:45400538-45400539(-) m6A CDS       24284625//24209618//27773535//22608085
chr14:45400545-45400546(-) m6A CDS       24284625//24209618//27773535//22608085
chr14:45400557-45400558(-) m6A CDS       24284625//24209618//27773535//22608085
chr14:45400568-45400569(-) m6A CDS       24284625//27773535//22608085
chr14:45400629-45400630(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr14:45400717-45400718(-) m6A CDS       24284625//24981863//27773535//22608085
chr14:45403320-45403321(-) m6A CDS       24284625//24981863//27773535//22608085
chr14:45403472-45403473(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr14:45403499-45403500(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr14:45403561-45403562(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:45403607-45403608(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:45403671-45403672(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:45403707-45403708(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:45414252-45414253(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr14:45414317-45414318(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:45414330-45414331(-) m6A CDS       24284625//24981863//27773535//22608085
chr14:45414336-45414337(-) m6A CDS       24284625//24981863//27773535//22608085
chr14:45414378-45414379(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:45414423-45414424(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr14:45414466-45414467(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr14:45414542-45414543(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr14:45414623-45414624(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr14:45414695-45414696(-) m6A CDS       24284625//27773535//22608085
chr14:45414777-45414778(-) m6A CDS       24284625//24981863//27773535//22608085
chr14:45414793-45414794(-) m6A CDS       24284625//24981863//27773535//22608085
chr14:45414823-45414824(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr14:45414842-45414843(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr14:45414881-45414882(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr14:45414913-45414914(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr14:45414931-45414932(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr14:45415032-45415033(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr14:45415074-45415075(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr14:45415126-45415127(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr14:45431053-45431054(-) m6A 5'UTR//intron       24981863
chr14:45431351-45431352(-) m6A 5'UTR//intron       25456834//24981863//22608085
chr14:45431385-45431386(-) m6A 5'UTR//intron       24284625//25456834//24981863//22608085
chr14:45433157-45433158(-) m6A exon//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr14:45447431-45447432(-) m6A 5'UTR//exon       24981863//22575960//22608085
chr14:45511327-45511328(-) m6A 5'UTR//exon       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365a-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
KLHL28
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365a-5p
Interactor2: KLHL28

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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