Basic Information:

  VIRBase ID:  

HHID00014709

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          MXRA8:  NM_001282582     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	MXRA8
miRBase Accession/Entrez ID	MIMAT0009199	54587
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ASP3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MXRA8	chr1:1288108-1288109(-) m6A 3'UTR//exon       27773535//22608085 chr1:1288185-1288186(-) m6A 3'UTR//exon       27773535 chr1:1288244-1288245(-) m6A 3'UTR//exon       24981863//27773535 chr1:1288410-1288411(-) m6A 3'UTR//exon       25456834//24981863//27773535 chr1:1288439-1288440(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535 chr1:1288540-1288541(-) m6A 3'UTR//exon       25456834//24981863//22608085 chr1:1288554-1288555(-) m6A 3'UTR//exon       25456834//24981863//22608085 chr1:1288634-1288635(-) m6A 3'UTR//exon       25456834//24981863 chr1:1288650-1288651(-) m6A 3'UTR//exon       25456834//24981863 chr1:1288664-1288665(-) m6A 3'UTR//exon       25456834//24981863 chr1:1288677-1288678(-) m6A 3'UTR//exon       25456834//24981863 chr1:1288711-1288712(-) m6A 3'UTR//CDS//exon       25456834//24981863 chr1:1289043-1289044(-) m6A exon//intron       - chr1:1289160-1289161(-) m6A exon//intron       - chr1:1289232-1289233(-) m6A CDS//exon       - chr1:1289444-1289445(-) m6A CDS//exon       - chr1:1289596-1289597(-) m6A CDS//exon       - chr1:1289658-1289659(-) m6A exon//intron       - chr1:1289696-1289697(-) m6A exon//intron       - chr1:1290131-1290132(-) m6A CDS//exon       - chr1:1290339-1290340(-) m6A CDS//exon       - chr1:1290351-1290352(-) m6A CDS//exon       - chr1:1290387-1290388(-) m6A CDS//exon       25456834 chr1:1290430-1290431(-) m6A CDS//exon       25456834 chr1:1290447-1290448(-) m6A CDS//exon       25456834 chr1:1290813-1290814(-) m6A exon//intron       24209618 chr1:1290820-1290821(-) m6A exon//intron       24209618 chr1:1290894-1290895(-) m6A CDS//intron       24209618 chr1:1290936-1290937(-) m6A CDS//intron       24209618 chr1:1290978-1290979(-) m6A CDS//intron       24209618 chr1:1291014-1291015(-) m6A CDS//intron       24209618 chr1:1291021-1291022(-) m6A CDS//intron       24209618 chr1:1293851-1293852(-) m6A CDS//intron       24209618 chr1:1293909-1293910(-) m6A 5'UTR//intron       24209618 chr1:1293926-1293927(-) m6A 5'UTR//intron       - chr1:1296657-1296658(-) m6A 5'UTR       25456834 chr1:1296947-1296948(-) m6A 5'UTR       24284625//25456834//22608085 chr1:1297081-1297082(-) m6A 5'UTR       25456834 chr1:1297102-1297103(-) m6A 5'UTR       - chr1:1297120-1297121(-) m6A 5'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	MXRA8	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: MXRA8

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).