Basic Information:

  VIRBase ID:  

HHID00014690

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365a-5p:  MIMAT0009199          TRAPPC4:  NM_001318494     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-365a-5p	TRAPPC4
miRBase Accession/Entrez ID	MIMAT0009199	51399
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CGI-104//HSPC172//NEDESBA//PTD009//SBDN//SYNBINDIN//TRS23

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-365a-5p	rs1166908611 chr16:14309308    T/C rs1368596991 chr16:14309314    G/A rs1380926089 chr16:14309318    A/G rs1396179427 chr16:14309310    G/C rs1428928383 chr16:14309320    G/A rs773834113 chr16:14309301    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TRAPPC4	chr11:118893429(+) A-I      intronic chr11:118893414(+) A-I      intronic chr11:118893236(+) A-I      intronic chr11:118893239(+) A-I      intronic chr11:118893456(+) A-I      intronic chr11:118893742(+) A-I      ncRNA chr11:118893855(+) A-I      ncRNA chr11:118893804(+) A-I      ncRNA chr11:118893864(+) A-I      ncRNA chr11:118893896(+) A-I      ncRNA chr11:118893897(+) A-I      ncRNA chr11:118893827(+) A-I      ncRNA chr11:118893820(+) A-I      ncRNA chr11:118893904(+) A-I      ncRNA chr11:118893895(+) A-I      ncRNA chr11:118893774(+) A-I      ncRNA chr11:118893884(+) A-I      ncRNA chr11:118893841(+) A-I      ncRNA chr11:118893231(+) A-I      intronic chr11:118893119(+) A-I      intronic chr11:118893563(+) A-I      intronic chr11:118892916(+) A-I      intronic chr11:118893105(+) A-I      intronic chr11:118892794(+) A-I      intronic chr11:118893127(+) A-I      intronic chr11:118893217(+) A-I      intronic chr11:118893137(+) A-I      intronic chr11:118893404(+) A-I      intronic chr11:118893141(+) A-I      intronic chr11:118893151(+) A-I      intronic chr11:118892719(+) A-I      intronic chr11:118893187(+) A-I      intronic chr11:118893247(+) A-I      intronic chr11:118893390(+) A-I      intronic chr11:118893148(+) A-I      intronic chr11:118893177(+) A-I      intronic chr11:118893219(+) A-I      intronic chr11:118893416(+) A-I      intronic chr11:118893081(+) A-I      intronic chr11:118893423(+) A-I      intronic chr11:118893889(+) A-I      ncRNA chr11:118893755(+) A-I      ncRNA chr11:118893877(+) A-I      ncRNA chr11:118893731(+) A-I      ncRNA chr11:118893909(+) A-I      ncRNA chr11:118893792(+) A-I      ncRNA chr11:118893752(+) A-I      ncRNA chr11:118893814(+) A-I      ncRNA chr11:118893226(+) A-I      intronic chr11:118893133(+) A-I      intronic chr11:118892968(+) A-I      intronic chr11:118893424(+) A-I      intronic chr11:118893136(+) A-I      intronic chr11:118893543(+) A-I      intronic chr11:118893450(+) A-I      intronic chr11:118892751(+) A-I      intronic chr11:118893135(+) A-I      intronic chr11:118893191(+) A-I      intronic chr11:118893552(+) A-I      intronic chr11:118893091(+) A-I      intronic chr11:118893285(+) A-I      intronic chr11:118893218(+) A-I      intronic chr11:118892824(+) A-I      intronic chr11:118893138(+) A-I      intronic chr11:118893045(+) A-I      intronic chr11:118892884(+) A-I      intronic chr11:118893398(+) A-I      intronic chr11:118893544(+) A-I      intronic chr11:118893459(+) A-I      intronic chr11:118893489(+) A-I      intronic chr11:118893037(+) A-I      intronic chr11:118893195(+) A-I      intronic chr11:118893399(+) A-I      intronic chr11:118893046(+) A-I      intronic chr11:118892812(+) A-I      intronic chr11:118893062(+) A-I      intronic chr11:118892795(+) A-I      intronic chr11:118892879(+) A-I      intronic chr11:118893244(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TRAPPC4	chr11:118893091(+) A-G intron -    22484847 chr11:118893195(+) A-G intron -    22484847 chr11:118893792(+) A-G intron -    22484847 chr11:118893814(+) A-G intron -    22484847 chr11:118893909(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRAPPC4	chr11:118889176-118889177(+) m6A 5'UTR       24284625//22608085 chr11:118889533-118889534(+) m6A CDS//exon       24981863//26404942 chr11:118889563-118889564(+) m6A CDS//exon       24981863//26404942//22575960 chr11:118889595-118889596(+) m6A CDS//exon       24981863//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-365a-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	TRAPPC4	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-365a-5p
Interactor2: TRAPPC4

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).